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A meta-database of Holocene sediment cores for England (2015)
Journal Article
Suggitt, A., Jones, R., Caseldine, C., Huntley, B., Stewart, J., Brooks, S., …Maclean, I. (2015). A meta-database of Holocene sediment cores for England. Vegetation History and Archaeobotany, 24(6), 743-747. https://doi.org/10.1007/s00334-015-0515-1

Extracting sediment cores for palaeoecological and archaeological investigations has occurred extensively across England since the early 20th century. Surprisingly, there has been comparatively little collation of these valuable publications and pote... Read More about A meta-database of Holocene sediment cores for England.

Proteomic analysis shows that stress response proteins are significantly up-regulated in resistant diploid wheat (Triticum monococcum) in response to attack by the grain aphid (Sitobion avenae) (2015)
Journal Article
Guan, W., Ferry, N., Edwards, M., Bell, H., Othman, H., Gatehouse, J., & Gatehouse, A. (2015). Proteomic analysis shows that stress response proteins are significantly up-regulated in resistant diploid wheat (Triticum monococcum) in response to attack by the grain aphid (Sitobion avenae). Molecular Breeding, 35(2), Article 57. https://doi.org/10.1007/s11032-015-0220-x

The grain aphid Sitobion avenae (F.) is a major pest of wheat, acting as a virus vector as well as causing direct plant damage. Commonly grown wheat varieties in the UK have only limited resistance to this pest. The present study was carried out to i... Read More about Proteomic analysis shows that stress response proteins are significantly up-regulated in resistant diploid wheat (Triticum monococcum) in response to attack by the grain aphid (Sitobion avenae).

Role of Δ1-Pyrroline-5-Carboxylate Dehydrogenase Supports Mitochondrial Metabolism and Host-Cell Invasion ofTrypanosoma cruzi (2015)
Journal Article
Mantilla, B. S., Paes, L. S., Pral, E. M., Martil, D. E., Thiemann, O. H., Fernández-Silva, P., …Silber, A. M. (2015). Role of Δ1-Pyrroline-5-Carboxylate Dehydrogenase Supports Mitochondrial Metabolism and Host-Cell Invasion ofTrypanosoma cruzi. Journal of Biological Chemistry, 290(12), 7767-7790. https://doi.org/10.1074/jbc.m114.574525

Proline is crucial for energizing critical events throughout the life cycle of Trypanosoma cruzi, the etiological agent of Chagas disease. The proline breakdown pathway consists of two oxidation steps, both of which producereducing equivalents as fol... Read More about Role of Δ1-Pyrroline-5-Carboxylate Dehydrogenase Supports Mitochondrial Metabolism and Host-Cell Invasion ofTrypanosoma cruzi.

Linked circadian outputs control elongation growth and flowering in response to photoperiod and temperature (2015)
Journal Article
Seaton, D., Smith, R., Song, Y., MacGregor, D., Stewart, K., Steel, G., …Halliday, K. (2015). Linked circadian outputs control elongation growth and flowering in response to photoperiod and temperature. Molecular Systems Biology, 11(1), Article 776. https://doi.org/10.15252/msb.20145766

Clock‐regulated pathways coordinate the response of many developmental processes to changes in photoperiod and temperature. We model two of the best‐understood clock output pathways in Arabidopsis, which control key regulators of flowering and elonga... Read More about Linked circadian outputs control elongation growth and flowering in response to photoperiod and temperature.

Glucose starvation and hypoxia, but not the saturated fatty acid palmitic acid or cholesterol, activate the unfolded protein response in 3T3-F442A and 3T3-L1 adipocytes (2015)
Journal Article
Mihai, A., & Schröder, M. (2015). Glucose starvation and hypoxia, but not the saturated fatty acid palmitic acid or cholesterol, activate the unfolded protein response in 3T3-F442A and 3T3-L1 adipocytes. Adipocyte, 4(3), 188-202. https://doi.org/10.4161/21623945.2014.989728

Obesity is associated with endoplasmic reticulum (ER) stress and activation of the unfolded protein response (UPR) in adipose tissue. In this study we identify physiological triggers of ER stress and of the UPR in adipocytes in vitro. We show that tw... Read More about Glucose starvation and hypoxia, but not the saturated fatty acid palmitic acid or cholesterol, activate the unfolded protein response in 3T3-F442A and 3T3-L1 adipocytes.

Protein–ligand interactions investigated by thermal shift assays (TSA) and dual polarization interferometry (DPI) (2015)
Journal Article
Grøftehauge, M. K., Hajizadeh, N. R., Swann, M. J., & Pohl, E. (2015). Protein–ligand interactions investigated by thermal shift assays (TSA) and dual polarization interferometry (DPI). Acta crystallographica. Section D, Biological crystallography, 71(1), 36-44. https://doi.org/10.1107/s1399004714016617

Over the last decades, a wide range of biophysical techniques investigating protein-ligand interactions have become indispensable tools to complement high-resolution crystal structure determinations. Current approaches in solution range from high-thr... Read More about Protein–ligand interactions investigated by thermal shift assays (TSA) and dual polarization interferometry (DPI).

Bayesian inference for palaeoclimate with time uncertainty and stochastic volatility (2015)
Journal Article
Parnell, A., Sweeney, J., Doan, T., Salter-Townshend, M., Allen, J., Huntley, B., & Haslett, J. (2015). Bayesian inference for palaeoclimate with time uncertainty and stochastic volatility. Journal of the Royal Statistical Society: Series C, 64(1), 115-138. https://doi.org/10.1111/rssc.12065

We propose and fit a Bayesian model to infer palaeoclimate over several thousand years. The data that we use arise as ancient pollen counts taken from sediment cores together with radiocarbon dates which provide (uncertain) ages. When combined with a... Read More about Bayesian inference for palaeoclimate with time uncertainty and stochastic volatility.