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Contrasting population genetic structure among freshwater-resident and anadromous lampreys: the role of demographic history, differential dispersal, and anthropogenic barriers to movement (2015)
Journal Article
Bracken, F., Hoelzel, A., Hume, J., & Lucas, M. (2015). Contrasting population genetic structure among freshwater-resident and anadromous lampreys: the role of demographic history, differential dispersal, and anthropogenic barriers to movement. Molecular Ecology, 24(6), 1188-1204. https://doi.org/10.1111/mec.13112

The tendency of many species to abandon migration remains a poorly understood aspect of evolutionary biology that may play an important role in promoting species radiation by both allopatric and sympatric mechanisms. Anadromy inherently offers an opp... Read More about Contrasting population genetic structure among freshwater-resident and anadromous lampreys: the role of demographic history, differential dispersal, and anthropogenic barriers to movement.

The AvecNet Trial to assess whether addition of pyriproxyfen, an insect juvenile hormone mimic, to long-lasting insecticidal mosquito nets provides additional protection against clinical malaria over current best practice in an area with pyrethroid-resistant vectors in rural Burkina Faso: study protocol for a randomised controlled trial (2015)
Journal Article
Tiono, A., Pinder, M., N'Fale, S., Faragher, B., Smith, T., Silkey, M., …Lindsay, S. (2015). The AvecNet Trial to assess whether addition of pyriproxyfen, an insect juvenile hormone mimic, to long-lasting insecticidal mosquito nets provides additional protection against clinical malaria over current best practice in an area with pyrethroid-resistant vectors in rural Burkina Faso: study protocol for a randomised controlled trial. Trials, 16, Article 113. https://doi.org/10.1186/s13063-015-0606-4

Background: Recent reductions in malaria in sub-Saharan Africa have been associated with increased coverage with long-lasting insecticidal nets (LLINs). Pyrethroids are currently the only insecticide class used for treating nets, and the rapid increa... Read More about The AvecNet Trial to assess whether addition of pyriproxyfen, an insect juvenile hormone mimic, to long-lasting insecticidal mosquito nets provides additional protection against clinical malaria over current best practice in an area with pyrethroid-resistant vectors in rural Burkina Faso: study protocol for a randomised controlled trial.

Adult vector control, mosquito ecology and malaria transmission (2015)
Journal Article
Brady, O., Godfray, H., Tatem, A., Gething, P., Cohen, J., McKenzie, F., …Smith, D. (2015). Adult vector control, mosquito ecology and malaria transmission. International Health, 7(2), 121-129. https://doi.org/10.1093/inthealth/ihv010

Background: Standard advice regarding vector control is to prefer interventions that reduce the lifespan of adult mosquitoes. The basis for this advice is a decades-old sensitivity analysis of ‘vectorial capacity’, a concept relevant for most malaria... Read More about Adult vector control, mosquito ecology and malaria transmission.

CopC Protein from Pseudomonas fluorescens SBW25 Features a Conserved Novel High-Affinity Cu(II) Binding Site (2015)
Journal Article
Wijekoon, C. J., Young, T. R., Wedd, A. G., & Xiao, Z. (2015). CopC Protein from Pseudomonas fluorescens SBW25 Features a Conserved Novel High-Affinity Cu(II) Binding Site. Inorganic Chemistry, 54(6), 2950-2959. https://doi.org/10.1021/acs.inorgchem.5b00031

Copper homeostasis in the bacterium Pseudomonas fluorescens SBW25 appears to be mediated mainly via chromosomal cue and cop systems. Under elevated copper levels that induce stress, the cue system is activated for expression of a P1B-type ATPase to r... Read More about CopC Protein from Pseudomonas fluorescens SBW25 Features a Conserved Novel High-Affinity Cu(II) Binding Site.

Comparison of senescence-associated miRNAs in primary skin and lung fibroblasts (2015)
Journal Article
Holly, A., Grellscheid, S., van de Walle, P., Dolan, D., Pilling, L., Daniels, D., …Harries, L. (2015). Comparison of senescence-associated miRNAs in primary skin and lung fibroblasts. Biogerontology, https://doi.org/10.1007/s10522-015-9560-5

MicroRNAs are non-coding RNAs with roles in many cellular processes. Tissue-specific miRNA profiles associated with senescence have been described for several cell and tissue types. We aimed to characterise miRNAs involved in core, rather than tissue... Read More about Comparison of senescence-associated miRNAs in primary skin and lung fibroblasts.

The green seaweed Ulva: a model system to study morphogenesis (2015)
Journal Article
Wichard, T., Charrier, B., Mineur, B., Bothwell, J., De Clerck, O., & Coates, J. (2015). The green seaweed Ulva: a model system to study morphogenesis. Frontiers in Plant Science, 6, Article 72. https://doi.org/10.3389/fpls.2015.00072

Green macroalgae, mostly represented by the Ulvophyceae, the main multicellular branch of the Chlorophyceae, constitute important primary producers of marine and brackish coastal ecosystems. Ulva or sea lettuce species are some of the most abundant r... Read More about The green seaweed Ulva: a model system to study morphogenesis.

The PDZ-domain protein whirlin facilitates mechanosensory signaling in mammalian proprioceptors (2015)
Journal Article
de Nooij, J. C., Simon, C. M., Simon, A., Doobar, S., Steel, K. P., Banks, R. W., …Jessell, T. M. (2015). The PDZ-domain protein whirlin facilitates mechanosensory signaling in mammalian proprioceptors. Journal of Neuroscience, 35(7), 3073-3084. https://doi.org/10.1523/jneurosci.3699-14.2015

Mechanoreception is an essential feature of many sensory modalities. Nevertheless, the mechanisms that govern the conversion of a mechanical force to distinct patterns of action potentials remain poorly understood. Proprioceptive mechanoreceptors res... Read More about The PDZ-domain protein whirlin facilitates mechanosensory signaling in mammalian proprioceptors.

A set of robust fluorescent peptide probes for quantification of Cu(II) binding affinities in the micromolar to femtomolar range (2015)
Journal Article
Young, T. R., Wijekoon, C. J., Spyrou, B., Donnelly, P. S., Wedd, A. G., & Xiao, Z. (2015). A set of robust fluorescent peptide probes for quantification of Cu(II) binding affinities in the micromolar to femtomolar range. Metallomics, 7(3), 567-578. https://doi.org/10.1039/c4mt00301b

Reliable quantification of copper binding affinities and identification of the binding sites provide a molecular basis for an understanding of the nutritional roles and toxic effects of copper ions. Sets of chromophoric probes are now available that... Read More about A set of robust fluorescent peptide probes for quantification of Cu(II) binding affinities in the micromolar to femtomolar range.

The Role of Phosphoglycans in the Susceptibility of Leishmania mexicana to the Temporin Family of Anti-Microbial Peptides (2015)
Journal Article
Eggimann, G., Sweeney, K., Bolt, H., Rozatian, N., Cobb, S., & Denny, P. (2015). The Role of Phosphoglycans in the Susceptibility of Leishmania mexicana to the Temporin Family of Anti-Microbial Peptides. Molecules, 20(2), 2775-2785. https://doi.org/10.3390/molecules20022775

Natural product antimicrobial peptides (AMPs) have been proposed as promising agents against the Leishmania species, insect vector borne protozoan parasites causing the neglected tropical disease leishmaniasis. However, recent studies have shown that... Read More about The Role of Phosphoglycans in the Susceptibility of Leishmania mexicana to the Temporin Family of Anti-Microbial Peptides.

Global low-frequency motions in protein allostery: CAP as a model system (2015)
Journal Article
Townsend, P., Rogers, T., Pohl, E., Wilson, M., McLeish, T., & Cann, M. (2015). Global low-frequency motions in protein allostery: CAP as a model system. Biophysical Reviews, 7(2), 175-182. https://doi.org/10.1007/s12551-015-0163-9

Allostery is a fundamental process by which ligand binding to a protein alters its activity at a distant site. There is considerable evidence that allosteric cooperativity can be communicated by the modulation of protein dynamics without conformation... Read More about Global low-frequency motions in protein allostery: CAP as a model system.

Foraging specialisms influence space use and movement patterns of the European eel Anguilla anguilla (2015)
Journal Article
Barry, J., Newton, M., Dodd, J., Hooker, O., Boylan, P., Lucas, M., & Adams, C. (2015). Foraging specialisms influence space use and movement patterns of the European eel Anguilla anguilla. Hydrobiologia, 766(1), 333-348. https://doi.org/10.1007/s10750-015-2466-z

A fixed receiver array was used to examine the movement patterns and space use of the European eel Anguilla anguilla in an oligotrophic Irish lake between July and September. We assessed home range size, temporal change in spatial behaviour and activ... Read More about Foraging specialisms influence space use and movement patterns of the European eel Anguilla anguilla.

A silk purse from a sow’s ear – bioinspired materials based on α-helical coiled coils (2015)
Journal Article
Quinlan, R., Bromley, E., & Pohl, E. (2015). A silk purse from a sow’s ear – bioinspired materials based on α-helical coiled coils. Current Opinion in Cell Biology, 32, 131-137. https://doi.org/10.1016/j.ceb.2014.12.010

This past few years have heralded remarkable times for intermediate filaments with new revelations of their structural properties that has included the first crystallographic-based model of vimentin to build on the experimental data of intra-filament... Read More about A silk purse from a sow’s ear – bioinspired materials based on α-helical coiled coils.

Beyond climate envelopes: Bio-climate modelling accords with observed 25-year changes in seabird populations of the British Isles (2015)
Journal Article
Russell, D., Wanless, S., Collingham, Y., Anderson, B., Beale, C., Reid, J., …Hamer, K. (2015). Beyond climate envelopes: Bio-climate modelling accords with observed 25-year changes in seabird populations of the British Isles. Diversity and Distributions, 21(2), 211-222. https://doi.org/10.1111/ddi.12272

Aim Climate envelope models (CEMs) are used to assess species’ vulnerability to predicted changes in climate, based on their distributions. Extinction risk, however, also depends on demographic parameters. Accordingly, we use CEMs for 18 seabird spec... Read More about Beyond climate envelopes: Bio-climate modelling accords with observed 25-year changes in seabird populations of the British Isles.

A functional Small Ubiquitin-like Modifier (SUMO) interacting motif (SIM) in the gibberellin hormone receptor GID1 is conserved in cereal crops and disrupting this motif does not abolish hormone dependency of the DELLA-GID1 interaction (2015)
Journal Article
Nelis, S., Conti, L., Zhang, C., & Sadanandom, A. (2015). A functional Small Ubiquitin-like Modifier (SUMO) interacting motif (SIM) in the gibberellin hormone receptor GID1 is conserved in cereal crops and disrupting this motif does not abolish hormone dependency of the DELLA-GID1 interaction. Plant Signaling & Behavior, 10(2), https://doi.org/10.4161/15592324.2014.987528

Plants survive adversity by modulating their growth in response to changing environmental signals. The phytohormone Gibberellic acid (GA) plays a central role in regulating these adaptive responses by stimulating the degradation of growth repressing... Read More about A functional Small Ubiquitin-like Modifier (SUMO) interacting motif (SIM) in the gibberellin hormone receptor GID1 is conserved in cereal crops and disrupting this motif does not abolish hormone dependency of the DELLA-GID1 interaction.

Consistent effects of disturbance and forest edges on the invasion of a continental rainforest by alien plants (2015)
Journal Article
Dawson, W., Burslem, D., & Hulme, P. (2015). Consistent effects of disturbance and forest edges on the invasion of a continental rainforest by alien plants. Biotropica, 47(1), 27-37. https://doi.org/10.1111/btp.12183

Continental tropical forests are thought to be resistant to alien plant invasion due to a lack of disturbance, or low propagule pressure from introduced species. We assessed the importance of disturbance and edge effects by surveying areas of submont... Read More about Consistent effects of disturbance and forest edges on the invasion of a continental rainforest by alien plants.

Functional analysis of a Wheat Homeodomain protein, TaR1, reveals that host chromatin remodelling influences the dynamics of the switch to necrotrophic growth in the phytopathogenic fungus Zymoseptoria tritici (2015)
Journal Article
Lee, J., Orosa, B., Millyard, L., Edwards, M., Kanyuka, K., Gatehouse, A., …Sadanandom, A. (2015). Functional analysis of a Wheat Homeodomain protein, TaR1, reveals that host chromatin remodelling influences the dynamics of the switch to necrotrophic growth in the phytopathogenic fungus Zymoseptoria tritici. New Phytologist, 206(2), 598-605. https://doi.org/10.1111/nph.13323

A distinguishing feature of Septoria leaf blotch disease in wheat is the long symptomless growth of the fungus amongst host cells followed by a rapid transition to necrotrophic growth resulting in disease lesions. Global reprogramming of host transcr... Read More about Functional analysis of a Wheat Homeodomain protein, TaR1, reveals that host chromatin remodelling influences the dynamics of the switch to necrotrophic growth in the phytopathogenic fungus Zymoseptoria tritici.

Mind the gap: house structure and the risk of malaria in Uganda (2015)
Journal Article
Wanzirah, H., Tusting, L., Arinaitwe, E., Katureebe, A., Maxwell, K., Rek, J., …Lindsay, S. (2015). Mind the gap: house structure and the risk of malaria in Uganda. PLoS ONE, 10(1), https://doi.org/10.1371/journal.pone.0117396

Background: Good house construction may reduce the risk of malaria by limiting the entry of mosquito vectors. We assessed how house design may affect mosquito house entry and malaria risk in Uganda. Methods: 100 households were enrolled in each of th... Read More about Mind the gap: house structure and the risk of malaria in Uganda.

A meta-database of Holocene sediment cores for England (2015)
Journal Article
Suggitt, A., Jones, R., Caseldine, C., Huntley, B., Stewart, J., Brooks, S., …Maclean, I. (2015). A meta-database of Holocene sediment cores for England. Vegetation History and Archaeobotany, 24(6), 743-747. https://doi.org/10.1007/s00334-015-0515-1

Extracting sediment cores for palaeoecological and archaeological investigations has occurred extensively across England since the early 20th century. Surprisingly, there has been comparatively little collation of these valuable publications and pote... Read More about A meta-database of Holocene sediment cores for England.