Skip to main content

Research Repository

Advanced Search

All Outputs (167)

Cbx4 maintains the epithelial lineage identity and cell proliferation in the developing stratified epithelium (2015)
Journal Article
Mardaryev, A., Liu, B., Rapisarda, V., Poterlowicz, K., Malashchuk, I., Rudolf, J., …Botchkarev, V. (2016). Cbx4 maintains the epithelial lineage identity and cell proliferation in the developing stratified epithelium. Journal of Cell Biology, 212(1), 77-89. https://doi.org/10.1083/jcb.201506065

During development, multipotent progenitor cells establish lineage-specific programmers of gene activation and silencing underlying their differentiation into specialized cell types. We show that the Polycomb component Cbx4 serves as a critical deter... Read More about Cbx4 maintains the epithelial lineage identity and cell proliferation in the developing stratified epithelium.

Maternal Oxytocin Is Linked to Close Mother-Infant Proximity in Grey Seals (Halichoerus grypus) (2015)
Journal Article
Robinson, K. J., Twiss, S. D., Hazon, N., & Pomeroy, P. P. (2015). Maternal Oxytocin Is Linked to Close Mother-Infant Proximity in Grey Seals (Halichoerus grypus). PLoS ONE, 10(12), Article e0144577. https://doi.org/10.1371/journal.pone.0144577

Maternal behaviour is a crucial component of reproduction in all mammals; however the quality of care that mothers give to infants can vary greatly. It is vital to document variation in maternal behaviour caused by the physiological processes control... Read More about Maternal Oxytocin Is Linked to Close Mother-Infant Proximity in Grey Seals (Halichoerus grypus).

Hypercapnia modulates cAMP signalling and cystic fibrosis transmembrane conductance regulator-dependent anion and fluid secretion in airway epithelia (2015)
Journal Article
Turner, M., Saint-Crib, V., Patel, W., Ibrahim, S., Verdon, B., Ward, C., …Gray, M. (2016). Hypercapnia modulates cAMP signalling and cystic fibrosis transmembrane conductance regulator-dependent anion and fluid secretion in airway epithelia. The Journal of Physiology, 594(6), 1643-1661. https://doi.org/10.1113/jp271309

Hypercapnia is clinically defined as an arterial blood partial pressure of CO2 of above 40 mmHg and is a feature of chronic lung disease. In previous studies we have demonstrated that hypercapnia modulates agonist-stimulated cAMP levels through effec... Read More about Hypercapnia modulates cAMP signalling and cystic fibrosis transmembrane conductance regulator-dependent anion and fluid secretion in airway epithelia.

Identification of MEDIATOR16 as the Arabidopsis COBRA suppressor, MONGOOSE1 (2015)
Journal Article
Sorek, N., Szemenyei, H., Sorek, H., Landers, A., Knight, H., Bauer, S., …Somerville, D. (2015). Identification of MEDIATOR16 as the Arabidopsis COBRA suppressor, MONGOOSE1. Proceedings of the National Academy of Sciences, 112(52), 16048-16053. https://doi.org/10.1073/pnas.1521675112

We performed a screen for genetic suppressors of cobra, an Arabidopsis mutant with defects in cellulose formation and an increased ratio of unesterified/esterified pectin. We identified a suppressor named mongoose1 (mon1) that suppressed the growth d... Read More about Identification of MEDIATOR16 as the Arabidopsis COBRA suppressor, MONGOOSE1.

Advances in 3D cell culture technologies enabling tissue-like structures to be created in vitro (2015)
Journal Article
Knight, E., & Przyborski, S. (2015). Advances in 3D cell culture technologies enabling tissue-like structures to be created in vitro. Journal of Anatomy, 227(6), 746-756. https://doi.org/10.1111/joa.12257

Research in mammalian cell biology often relies on developing in vitro models to enable the growth of cells in the laboratory to investigate a specific biological mechanism or process under different test conditions. The quality of such models and ho... Read More about Advances in 3D cell culture technologies enabling tissue-like structures to be created in vitro.

Land sparing, land sharing, and the fate of Africa's lions (2015)
Journal Article
Stephens, P. (2015). Land sparing, land sharing, and the fate of Africa's lions. Proceedings of the National Academy of Sciences, 112(48), 14753-14754. https://doi.org/10.1073/pnas.1520709112

Taxonomic bias in organismal research and conservation is well recognized, with focus disproportionately directed toward birds and mammals (1). Among mammals, carnivores often receive excessive attention and large carnivores are particularly well stu... Read More about Land sparing, land sharing, and the fate of Africa's lions.

A tale of two paralogs: human Transformer2 proteins with differential RNA-binding affinities (2015)
Journal Article
Ghosh, P., Grellscheid, S. N., & Sowdhamini, R. (2016). A tale of two paralogs: human Transformer2 proteins with differential RNA-binding affinities. Journal of Biomolecular Structure and Dynamics, 34(9), 1979-1986. https://doi.org/10.1080/07391102.2015.1100551

The Transformer2 (Tra2) proteins in humans are homologues of the Drosophila Tra2 protein. One of the two RNA-binding paralogs, Tra2β, has been very well-studied over the past decade, but not much is known about Tra2α. It was very recently shown that... Read More about A tale of two paralogs: human Transformer2 proteins with differential RNA-binding affinities.

Using Zinc Finger Nuclease Technology to Generate CRX-Reporter Human Embryonic Stem Cells as a Tool to Identify and Study the Emergence of Photoreceptors Precursors During Pluripotent Stem Cell Differentiation (2015)
Journal Article
Collin, J., Mellough, C., Dorgau, B., Przyborski, S., Moreno-Gimeno, I., & Lako, M. (2016). Using Zinc Finger Nuclease Technology to Generate CRX-Reporter Human Embryonic Stem Cells as a Tool to Identify and Study the Emergence of Photoreceptors Precursors During Pluripotent Stem Cell Differentiation. Stem Cells, 34(2), 311-321. https://doi.org/10.1002/stem.2240

The purpose of this study was to generate human embryonic stem cell (hESC) lines harboring the green fluorescent protein (GFP) reporter at the endogenous loci of the Cone-Rod Homeobox (CRX) gene, a key transcription factor in retinal development. Zin... Read More about Using Zinc Finger Nuclease Technology to Generate CRX-Reporter Human Embryonic Stem Cells as a Tool to Identify and Study the Emergence of Photoreceptors Precursors During Pluripotent Stem Cell Differentiation.

The tomato Nucleotide-Binding Leucine-Rich Repeat (NLR) Immune Receptor I-2 couples DNA-Binding to Nucleotide-Binding Domain Nucleotide Exchange (2015)
Journal Article
Fenyk, S., Dixon, C., Kittens, W., Townsend, P., Sharpies, G., Pålsson, L., …Cann, M. (2016). The tomato Nucleotide-Binding Leucine-Rich Repeat (NLR) Immune Receptor I-2 couples DNA-Binding to Nucleotide-Binding Domain Nucleotide Exchange. Journal of Biological Chemistry, 291(3), 1137-1147. https://doi.org/10.1074/jbc.m115.698589

Plant nucleotide-binding leucine-rich repeat (NLR) proteins enable plants to recognise and respond to pathogen attack. Previously, we demonstrated that the Rx1 NLR of potato is able to bind and bend DNA in vitro. DNA binding in situ requires its genu... Read More about The tomato Nucleotide-Binding Leucine-Rich Repeat (NLR) Immune Receptor I-2 couples DNA-Binding to Nucleotide-Binding Domain Nucleotide Exchange.

Suppression of the homeobox gene HDTF1 enhances resistance to Verticillium dahliae and Botrytis cinerea in cotton (2015)
Journal Article
Gao, W., Long, L., Xu, L., Lindsey, K., Zhang, X., & Zhu, L. (2016). Suppression of the homeobox gene HDTF1 enhances resistance to Verticillium dahliae and Botrytis cinerea in cotton. Journal of Integrative Plant Biology, 58(5), 503-513. https://doi.org/10.1111/jipb.12432

Development of pathogen-resistant crops, such as fungus-resistant cotton, has significantly reduced chemical application and improved crop yield and quality. However, the mechanism of resistance to cotton pathogens such as Verticillium dahliae is sti... Read More about Suppression of the homeobox gene HDTF1 enhances resistance to Verticillium dahliae and Botrytis cinerea in cotton.

Preparation of an antibacterial poly(ionic liquid) graft copolymer of hydroxyethyl cellulose (2015)
Journal Article
Joubert, F., Yeo, R. P., Sharples, G. J., Musa, O. M., Hodgson, D. R., & Cameron, N. R. (2015). Preparation of an antibacterial poly(ionic liquid) graft copolymer of hydroxyethyl cellulose. Biomacromolecules, 16(12), 397-3979. https://doi.org/10.1021/acs.biomac.5b01300

Poly(ionic liquid)s (P(IL)s) of different degrees of polymerisation (10, 50 and 100) were prepared via RAFT polymerisation using an alkyne-terminated xanthate as transfer agent, with a monomer conversion of up to ~80% and a ƉM of 1.5 for P(IL)100. Su... Read More about Preparation of an antibacterial poly(ionic liquid) graft copolymer of hydroxyethyl cellulose.

Fish fauna of the Brahmaputra River, Bangladesh: richness, threats and conservation needs (2015)
Journal Article
Galib, S. (2015). Fish fauna of the Brahmaputra River, Bangladesh: richness, threats and conservation needs. Journal of fisheries (Rajshahi), 3(3), 285-292. https://doi.org/10.17017/jfish.v3i3.2015.120

The Brahmaputra River is one of the largest rivers in the world as well as in Bangladesh. The present study was carried out for a period of one year from January to December 2013 with a view to assessing the availability of fishes in the river with s... Read More about Fish fauna of the Brahmaputra River, Bangladesh: richness, threats and conservation needs.

In vivo, Ex Vivo, and In VitroApproaches to Study IntermediateFilaments in the Eye Lens (2015)
Journal Article
Jarrin, M., Young, L., Wu, W., Girkin, J., & Quinlan, R. (2016). In vivo, Ex Vivo, and In VitroApproaches to Study IntermediateFilaments in the Eye Lens. Methods in enzymology, 568, 581-611. https://doi.org/10.1016/bs.mie.2015.09.010

The role of the eye lens is to focus light into the retina. To perform this unique function, the ocular lens must be transparent. Previous studies have demonstrated the expression of vimentin, BFSP1, and BFSP2 in the eye lens. These intermediate fila... Read More about In vivo, Ex Vivo, and In VitroApproaches to Study IntermediateFilaments in the Eye Lens.

Predicting Future European Breeding Distributions of British Seabird Species under Climate Change and Unlimited/No Dispersal Scenarios (2015)
Journal Article
Russell, D., Wanless, S., Collingham, Y., Huntley, B., & Hamer, K. (2015). Predicting Future European Breeding Distributions of British Seabird Species under Climate Change and Unlimited/No Dispersal Scenarios. Diversity, 7(4), 342-359. https://doi.org/10.3390/d7040342

Understanding which traits make species vulnerable to climatic change and predicting future distributions permits conservation efforts to be focused on the most vulnerable species and the most appropriate sites. Here, we combine climate envelope mode... Read More about Predicting Future European Breeding Distributions of British Seabird Species under Climate Change and Unlimited/No Dispersal Scenarios.

Global trade will accelerate plant invasions in emerging economies under climate change (2015)
Journal Article
Seebens, H., Essl, F., Dawson, W., Fuentes, N., Moser, D., Pergl, J., …Blasius, B. (2015). Global trade will accelerate plant invasions in emerging economies under climate change. Global Change Biology, 21(11), 4128-4140. https://doi.org/10.1111/gcb.13021

Trade plays a key role in the spread of alien species and has arguably contributed to the recent enormous acceleration of biological invasions, thus homogenizing biotas worldwide. Combining data on 60-year trends of bilateral trade, as well as on bio... Read More about Global trade will accelerate plant invasions in emerging economies under climate change.

Multi-scale Approaches to Dynamical Transmission of Protein Allostery (2015)
Presentation / Conference Contribution
Townsend, P., Rodgers, T., Pohl, E., Wilson, M., Cann, M., & McLeish, T. (2015). Multi-scale Approaches to Dynamical Transmission of Protein Allostery. In L. Olivares-Quiroz, O. Guzmán-López, & H. E. Jardón-Valadez (Eds.), Physical Biology of Proteins and Peptides: Theory, Experiment, and Simulation (141-152). https://doi.org/10.1007/978-3-319-21687-4_8

We review the idea that allosteric interactions can be transmitted not by structural switching but by the more subtle route of modulation of the amplitude of thermally-activated global dynamical modes in allosteric proteins. The effect is naturally a... Read More about Multi-scale Approaches to Dynamical Transmission of Protein Allostery.

Niche dynamics of alien species do not differ among sexual and apomictic flowering plants (2015)
Journal Article
Dellinger, A., Essl, F., Hojsgaard, D., Kirchheimer, B., Klatt, S., Dawson, W., …Dullinger, S. (2016). Niche dynamics of alien species do not differ among sexual and apomictic flowering plants. New Phytologist, 209(3), 1313-1323. https://doi.org/10.1111/nph.13694

Biological invasions can be associated with shifts of the species’ climatic niches but the incidence of such shifts is under debate. The reproductive system might be a key factor controlling such shifts because it influences a species’ evolutionary f... Read More about Niche dynamics of alien species do not differ among sexual and apomictic flowering plants.

Armigeres subalbatus colonization of damaged pit latrines: a nuisance and potential health risk to residents of resettlement villages in Laos (2015)
Journal Article
Hiscox, A., Hirooka, R., Vongphayloth, K., Hill, N., Lindsay, S., Grandadam, M., & Brey, P. (2016). Armigeres subalbatus colonization of damaged pit latrines: a nuisance and potential health risk to residents of resettlement villages in Laos. Medical and Veterinary Entomology, 30(1), 95-100. https://doi.org/10.1111/mve.12142

During the resettlement of 6500 persons living around the Nam Theun 2 hydroelectric project in Laos, more than 1200 pour-flush latrines were constructed. To assess the role of these latrines as productive larval habitats for mosquitoes, entomological... Read More about Armigeres subalbatus colonization of damaged pit latrines: a nuisance and potential health risk to residents of resettlement villages in Laos.