All Outputs (3)

A nucleotidyltransferase toxin inhibits growth of Mycobacterium tuberculosis through inactivation of tRNA acceptor stems (2020)
Journal Article
Cai, Y., Usher, B., Gutierrez, C., Tolcan, A., Mansour, M., Fineran, P., …Blower, T. (2020). A nucleotidyltransferase toxin inhibits growth of Mycobacterium tuberculosis through inactivation of tRNA acceptor stems. Science Advances, 6(31), Article eabb6651. https://doi.org/10.1126/sciadv.abb6651

Toxin-antitoxin systems are widespread stress-responsive elements, many of whose functions remain largely unknown. Here, we characterize the four DUF1814-family nucleotidyltransferase-like toxins (MenT1–4) encoded by the human pathogen Mycobacterium... Read More about A nucleotidyltransferase toxin inhibits growth of Mycobacterium tuberculosis through inactivation of tRNA acceptor stems.

Antitoxin autoregulation of M. tuberculosis toxin-antitoxin expression through negative cooperativity arising from multiple inverted repeat sequences (2020)
Journal Article
Beck, I., Usher, B., Hampton, H., Fineran, P., & Blower, T. (2020). Antitoxin autoregulation of M. tuberculosis toxin-antitoxin expression through negative cooperativity arising from multiple inverted repeat sequences. Biochemical Journal, 477(12), 2401-2419. https://doi.org/10.1042/bcj20200368

Toxin-antitoxin systems play key roles in bacterial adaptation, including protection from antibiotic assault and infection by bacteriophages. The type IV toxin-antitoxin system AbiE encodes a DUF1814 nucleotidyltransferase-like toxin, and a two-domai... Read More about Antitoxin autoregulation of M. tuberculosis toxin-antitoxin expression through negative cooperativity arising from multiple inverted repeat sequences.

Anticancer Ruthenium Complexes with HDAC Isoform Selectivity (2020)
Journal Article
Cross, J., Blower, T., Kingdon, A., Pal, R., Picton, D., & Walton, J. (2020). Anticancer Ruthenium Complexes with HDAC Isoform Selectivity. Molecules, 25(10), Article 2383. https://doi.org/10.3390/molecules25102383

The histone deacetylase (HDAC) enzymes have emerged as an important class of molecular targets in cancer therapy, with five inhibitors in clinical use. Recently, it has been shown that a lack of selectivity between the 11 Zn-dependent HDAC isoforms m... Read More about Anticancer Ruthenium Complexes with HDAC Isoform Selectivity.