All Outputs (3)

Anticancer RuII and RhIII Piano-Stool Complexes that are Histone Deacetylase Inhibitors (2016)
Journal Article
Cross, J., Blower, T., Gallagher, N., Gill, J., Rockley, K., & Walton, J. (2016). Anticancer RuII and RhIII Piano-Stool Complexes that are Histone Deacetylase Inhibitors. ChemPlusChem, 81(12), 1276-1280. https://doi.org/10.1002/cplu.201600413

The first examples of RuII and RhIII piano-stool complex histone deacetylase (HDAC) inhibitors are presented. The novel complexes have antiproliferative activity against H460 non-small-cell lung carcinoma cells that is comparable to the clinically us... Read More about Anticancer RuII and RhIII Piano-Stool Complexes that are Histone Deacetylase Inhibitors.

Fluoroquinolone interactions with Mycobacterium tuberculosis gyrase: Enhancing drug activity against wild-type and resistant gyrase (2016)
Journal Article
Aldred, K., Blower, T., Kerns, R., Berger, J., & Osheroff, N. (2016). Fluoroquinolone interactions with Mycobacterium tuberculosis gyrase: Enhancing drug activity against wild-type and resistant gyrase. Proceedings of the National Academy of Sciences, 113(7), E839-E846. https://doi.org/10.1073/pnas.1525055113

Mycobacterium tuberculosis is a significant source of global morbidity and mortality. Moxifloxacin and other fluoroquinolones are important therapeutic agents for the treatment of tuberculosis, particularly multidrug-resistant infections. To guide th... Read More about Fluoroquinolone interactions with Mycobacterium tuberculosis gyrase: Enhancing drug activity against wild-type and resistant gyrase.

Crystal structure and stability of gyrase–fluoroquinolone cleaved complexes from Mycobacterium tuberculosis (2016)
Journal Article
Blower, T., Williamson, B., Kerns, R., & Berger, J. (2016). Crystal structure and stability of gyrase–fluoroquinolone cleaved complexes from Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences, 113(7), 1706-1713. https://doi.org/10.1073/pnas.1525047113

Mycobacterium tuberculosis (Mtb) infects one-third of the world’s population and in 2013 accounted for 1.5 million deaths. Fluoroquinolone antibacterials, which target DNA gyrase, are critical agents used to halt the progression from multidrug-resist... Read More about Crystal structure and stability of gyrase–fluoroquinolone cleaved complexes from Mycobacterium tuberculosis.