All Outputs (4)

Investigating the Anti-leishmanial Effects of Linear Peptoids (2014)
Journal Article
Eggimann, G., Bolt, H., Denny, P., & Cobb, S. (2015). Investigating the Anti-leishmanial Effects of Linear Peptoids. ChemMedChem, 10(3), 233-237. https://doi.org/10.1002/cmdc.201402416

Peptoids, a class of peptide mimetics, have emerged as promising anti-infective agents against a range of bacterial infections. Herein we present the first study of the antiparasitic and specifically the anti-leishmanial properties of linear peptoids... Read More about Investigating the Anti-leishmanial Effects of Linear Peptoids.

Novel fluorinated lipopeptides from Bacillus sp. CS93 via precursor-directed biosynthesis (2014)
Journal Article
O’Connor, N., Hudson, A., Cobb, S., O’Neil, D., Robertson, J., Duncan, V., & Murphy, C. (2014). Novel fluorinated lipopeptides from Bacillus sp. CS93 via precursor-directed biosynthesis. Amino Acids, 46(12), 2745-2752. https://doi.org/10.1007/s00726-014-1830-z

While attempting to improve production of fluoro-iturin A in Bacillus sp. CS93 new mono- and di-fluorinated fengycins were detected in culture supernatants by 19F NMR and tandem mass spectrometry, after incubation of the bacterium with 3-fluoro-l-tyr... Read More about Novel fluorinated lipopeptides from Bacillus sp. CS93 via precursor-directed biosynthesis.

A mild method for the synthesis of a novel dehydrobutyrine-containing amino acid (2014)
Journal Article
Webster, A. M., Coxon, C. R., Kenwright, A. M., Sandford, G., & Cobb, S. L. (2014). A mild method for the synthesis of a novel dehydrobutyrine-containing amino acid. Tetrahedron, 70(31), 4661-4667. https://doi.org/10.1016/j.tet.2014.05.031

Dehydrobutyrine is an amino acid that is present in a range of peptide natural products. Reaction of pentafluoropyridine with threonine and subsequent E1cb-type elimination allowed the preparation of novel dehydrobutyrine-containing amino acids under... Read More about A mild method for the synthesis of a novel dehydrobutyrine-containing amino acid.

Blending gelators to tune gel properties and probe anion-induced disassembly (2014)
Journal Article
Foster, J., Edkins, R., Cameron, G., Colgin, N., Fucke, K., Ridgeway, S., …Steed, J. (2014). Blending gelators to tune gel properties and probe anion-induced disassembly. Chemistry - A European Journal, 20(1), 279-291. https://doi.org/10.1002/chem.201303153

Blending different low molecular weight gelators (LMWGs) provides a convenient route to tune the properties of a gel and incorporate functionalities such as fluorescence. Blending a series of gelators having a common bis-urea motif, and functionalise... Read More about Blending gelators to tune gel properties and probe anion-induced disassembly.