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Lamin A/C binding protein LAP2 alpha is required for nuclear anchorageof retinoblastoma protein (2002)
Journal Article
Markiewicz, E., Dechat, T., Foisner, R., Quinlan, R., & Hutchison, C. (2002). Lamin A/C binding protein LAP2 alpha is required for nuclear anchorageof retinoblastoma protein. Molecular Biology of the Cell, 13(12), 4401-4413. https://doi.org/10.1091/mbc.e02-07-0450

The phosphorylation-dependent anchorage of retinoblastoma protein Rb in the nucleus is essential for its function. We show that its pocket C domain is both necessary and sufficient for nuclear anchorage by transiently expressing green fluorescent pro... Read More about Lamin A/C binding protein LAP2 alpha is required for nuclear anchorageof retinoblastoma protein.

Differential effect of simvastatin on activation of Rac(1) vs.activation of the heat shock protein 27-mediated pathway upon oxidativestress, in human smooth muscle cells (2002)
Journal Article
Negre-Aminou, P., van Leeuwen, R., van Thiel, G., van den IJssel, P., de Jong, W., Quinlan, R., & Cohen, L. (2002). Differential effect of simvastatin on activation of Rac(1) vs.activation of the heat shock protein 27-mediated pathway upon oxidativestress, in human smooth muscle cells. Biochemical Pharmacology, 64(10), 1483-1491

Altered aggregation properties of mutant gamma-crystallins cause inherited cataract (2002)
Journal Article
Sandilands, A., Hutcheson, A., Long, H., Prescott, A., Vrensen, G., Löster, J., …Quinlan, R. (2002). Altered aggregation properties of mutant gamma-crystallins cause inherited cataract. The EMBO Journal, 21(22), 6005-6014. https://doi.org/10.1093/emboj/cdf609

Protein inclusions are associated with a diverse group of human diseases ranging from localized neurological disorders through to systemic non-neuropathic diseases. Here, we present evidence that the formation of intranuclear inclusions is a key even... Read More about Altered aggregation properties of mutant gamma-crystallins cause inherited cataract.

Association of the nuclear matrix component NuMA with the Cajal bodyand nuclear speckle compartments during transitions in transcriptionalactivity in lens cell differentiation (2002)
Journal Article
Gribbon, C., Dahm, R., Prescott, A., & Quinlan, R. (2002). Association of the nuclear matrix component NuMA with the Cajal bodyand nuclear speckle compartments during transitions in transcriptionalactivity in lens cell differentiation. European Journal of Cell Biology, 81(10), 557-566. https://doi.org/10.1078/0171-9335-00275

The transcriptional status of cells can be deduced from the staining pattern of various nuclear markers such as the Cajal body, nucleolus and nuclear speckles. In this study we have used these markers to correlate transcriptional status with cell dif... Read More about Association of the nuclear matrix component NuMA with the Cajal bodyand nuclear speckle compartments during transitions in transcriptionalactivity in lens cell differentiation.