Rationalized Computer-Aided design of Matrix Metalloprotease-Selective Prodrugs
(2017)
Journal Article
Jain, M., Harburn, J., Gill, J., Loadman, P., Falconer, R., Mooney, C., …Berry, D. (2017). Rationalized Computer-Aided design of Matrix Metalloprotease-Selective Prodrugs. Journal of Medicinal Chemistry, 60(10), 4496-4502. https://doi.org/10.1021/acs.jmedchem.6b01472
Matrix metalloproteinases (MMPs) are central to cancer development and metastasis. They are highly active in the tumour environment and absent or inactive in normal tissues; therefore they represent viable targets for cancer drug discovery. In this s... Read More about Rationalized Computer-Aided design of Matrix Metalloprotease-Selective Prodrugs.