Evaluation of the Leishmania inositol phosphorylceramide synthase as a drug target using a chemical and genetic approach
(2024)
Journal Article
Alpizar-Sosa, E. A., Zimbres, F. M., Mantilla, B. S., Dickie, E. A., Wei, W., Burle-Caldas, G. A., Filipe, L. N., Van Bocxlaer, K., Price, H. P., Ibarra-Meneses, A. V., Beaudry, F., Fernandez-Prada, C., Whitfield, P. D., Barrett, M. P., & Denny, P. W. (2024). Evaluation of the Leishmania inositol phosphorylceramide synthase as a drug target using a chemical and genetic approach. ACS Infectious Diseases, https://doi.org/10.1021/acsinfecdis.4c00284
The lack of effective vaccines and the development of resistance to the current treatments highlight the urgent need for new anti-leishmanials. Sphingolipid metabolism has been proposed as a promising source of -specific targets as these lipids are... Read More about Evaluation of the Leishmania inositol phosphorylceramide synthase as a drug target using a chemical and genetic approach.