An Efficient Route To S-N-(9-Fluorenylmethoxycarbonyl)-4'-(1-Azi-2,2,2-Trifluoroethyl)phenylalanine
(1994)
Journal Article
Fishwick, C., Sanderson, J., & Findlay, J. (1994). An Efficient Route To S-N-(9-Fluorenylmethoxycarbonyl)-4'-(1-Azi-2,2,2-Trifluoroethyl)phenylalanine. Tetrahedron Letters, 35(26), 4611-4614. https://doi.org/10.1016/s0040-4039%2800%2960743-8
An extremely efficient synthesis of optically pure photoactivatable phenylalanine derivative 1 is described. The key step involves a highly diastereoselective alkylation of a chiral glycine equivalent.