Pyridylphosphinate Metal Complexes: Synthesis, Structural Characterisation and Biological Activity

Cross, J.M.; Gallagher, N.; Gill, J.H.; Jain, M.; McNeillis, A.W.; Rockley, K.L.; Tscherny, F.H.; Wirszycz, N.J.; Yufit, D.S.; Walton, J.W.

doi:10.1039/c6dt01264g

All Outputs (2)

Anticancer RuII and RhIII Piano-Stool Complexes that are Histone Deacetylase Inhibitors (2016)
Journal Article
Cross, J., Blower, T., Gallagher, N., Gill, J., Rockley, K., & Walton, J. (2016). Anticancer RuII and RhIII Piano-Stool Complexes that are Histone Deacetylase Inhibitors. ChemPlusChem, 81(12), 1276-1280. https://doi.org/10.1002/cplu.201600413

The first examples of RuII and RhIII piano-stool complex histone deacetylase (HDAC) inhibitors are presented. The novel complexes have antiproliferative activity against H460 non-small-cell lung carcinoma cells that is comparable to the clinically us... Read More about Anticancer RuII and RhIII Piano-Stool Complexes that are Histone Deacetylase Inhibitors.

Pyridylphosphinate Metal Complexes: Synthesis, Structural Characterisation and Biological Activity (2016)
Journal Article
Cross, J., Gallagher, N., Gill, J., Jain, M., McNeillis, A., Rockley, K., …Walton, J. (2016). Pyridylphosphinate Metal Complexes: Synthesis, Structural Characterisation and Biological Activity. Dalton Transactions, 45(32), 12807-12813. https://doi.org/10.1039/c6dt01264g

For the first time, a series of 25 pseudo-octahedral pyridylphosphinate metal complexes (Ru, Os, Rh, Ir) has been synthesised and assessed in biological systems. Each metal complex incorporates a pyridylphosphinate ligand, a monodentate halide and a... Read More about Pyridylphosphinate Metal Complexes: Synthesis, Structural Characterisation and Biological Activity.