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All Outputs (71)

Implant Optimisation for Primary Hip Replacement in Patients over 60 Years with Osteoarthritis: A Cohort Study of Clinical Outcomes and Implant Costs Using Data from England and Wales (2015)
Journal Article

Background Hip replacement is one of the most commonly performed surgical procedures worldwide; hundreds of implant configurations provide options for femoral head size, joint surface material and fixation method with dramatically varying costs. Robu... Read More about Implant Optimisation for Primary Hip Replacement in Patients over 60 Years with Osteoarthritis: A Cohort Study of Clinical Outcomes and Implant Costs Using Data from England and Wales.

Parental reminder, recall and educational interventions to improve early childhood immunisation uptake: A systematic review and meta-analysis (2015)
Journal Article

Vaccination is one of the most effective ways of reducing childhood mortality. Despite global uptake of childhood vaccinations increasing, rates remain sub-optimal, meaning that vaccine-preventable diseases still pose a public health risk. A range of... Read More about Parental reminder, recall and educational interventions to improve early childhood immunisation uptake: A systematic review and meta-analysis.

'Therapeutic landscapes' and the importance of nostalgia, solastalgia, salvage and abandonment for psychiatric hospital design (2015)
Journal Article

We examine emotional reactions to changes to medical spaces of care, linked with past experiences. In this paper we draw on findings from a qualitative study of the transfer of psychiatric inpatient care from an old to a newly built facility. We show... Read More about 'Therapeutic landscapes' and the importance of nostalgia, solastalgia, salvage and abandonment for psychiatric hospital design.

Ultrasound observations of subtle movements: a pilot study comparing fetuses of smoking and non-smoking mothers (2015)
Journal Article

Aim: One way to assess fetal health of smokers is to ask mothers to count perceived movements, an unreliable method hiding differences in prenatal development. The aim of this pilot study was to assess subtle fetal movements in ultrasound-scans and e... Read More about Ultrasound observations of subtle movements: a pilot study comparing fetuses of smoking and non-smoking mothers.

No functional benefit of larger femoral heads and alternative bearings at 6 months following primary hip replacement (2015)
Journal Article

Background and purpose — There has been a recent trend towards the use of greater femoral head sizes in an attempt to improve function and enhance stability after primary hip replacement. This has been associated with the use of alternative bearings,... Read More about No functional benefit of larger femoral heads and alternative bearings at 6 months following primary hip replacement.

Have cementless and resurfacing components improved the medium-term results of hip replacement for patients under 60 years of age? Patient-reported outcome measures, implant survival, and costs in 24,709 patients (2015)
Journal Article

Background and purpose — The optimal hip replacement for young patients remains unknown. We compared patient-reported outcome measures (PROMs), revision risk, and implant costs over a range of hip replacements. Methods — We included hip replacements... Read More about Have cementless and resurfacing components improved the medium-term results of hip replacement for patients under 60 years of age? Patient-reported outcome measures, implant survival, and costs in 24,709 patients.

Biodegradable stent or balloon dialation for benign oesophageal stricture: pilot randomised controlled trial (2014)
Journal Article

AIM: To undertake a randomised pilot study comparing biodegradable stents and endoscopic dilatation in patients with strictures. METHODS: This British multi-site study recruited seventeen symptomatic adult patients with refractory strictures. Patient... Read More about Biodegradable stent or balloon dialation for benign oesophageal stricture: pilot randomised controlled trial.

A prospective trial of temporary sacral nerve stimulation for constipation associated with neurological disease (2014)
Journal Article

Aim: The study assessed the effectiveness of temporary sacral nerve stimulation (SNS) in patients with constipation associated with neurological disease using an off-on-off design and evaluated the long-term response in patients undergoing permanent... Read More about A prospective trial of temporary sacral nerve stimulation for constipation associated with neurological disease.

The Impact of Body Mass Index on Patient Reported Outcome Measures (Proms) and Complications Following Primary Hip Replacement (2014)
Journal Article

Influence of BMI upon patient outcomes and complications following THA was examined across a national cohort of patients. Outcomes were compared by BMI groups (19.0–29.9 kg/m2 [reference], 30.0–34.9 kg/m2 [obese class I], 35.0 kg/m2+ [obese class II/... Read More about The Impact of Body Mass Index on Patient Reported Outcome Measures (Proms) and Complications Following Primary Hip Replacement.

The effect of tranexamic acid on artificial joint materials : a biomechanical study (the bioTRANX study) (2014)
Journal Article

Background Tranexamic acid (TXA) has been successfully used to reduce bleeding in joint replacement. Recently local TXA has been advocated to reduce blood loss in total knee or hip replacement; however, this raised concerns about potential adverse ef... Read More about The effect of tranexamic acid on artificial joint materials : a biomechanical study (the bioTRANX study).

The development of anticipation in the fetus: a longitudinal account of human fetal mouth movements in reaction to and anticipation of touch (2014)
Journal Article

Background: Research suggests that fetuses open or close their mouth in relation to directed movements (e.g. Myowa-Yamakoshi & Takeshita, 2006) but it is unclear whether mouth opening anticipates the touch or is a reaction to touch, as there has been... Read More about The development of anticipation in the fetus: a longitudinal account of human fetal mouth movements in reaction to and anticipation of touch.

Cardiopulmonary Exercise Testing for Preoperative Risk Assessment before Pancreaticoduodenectomy for Cancer (2014)
Journal Article

Objective. Pancreaticoduodenectomy is the standard of care for tumors confined to the head of pancreas and can be undertaken with low operative mortality. The procedure has a high morbidity, particularly in older patient populations with preexisting... Read More about Cardiopulmonary Exercise Testing for Preoperative Risk Assessment before Pancreaticoduodenectomy for Cancer.

Barriers to accurate diagnosis and effective management of heart failure have not changed in the past 10 years: a qualitative study and national survey (2014)
Journal Article

Objectives: To explore changes in healthcare professionals’ views about the diagnosis and management of heart failure since a study in 2003. Design: Focus groups and a national online cross-sectional survey. Setting and participants: Focus groups (n=... Read More about Barriers to accurate diagnosis and effective management of heart failure have not changed in the past 10 years: a qualitative study and national survey.

Prospective pilot evaluation of the effectiveness and cost-utility of a "health first" case management service for long-term Incapacity Benefit recipients (2014)
Journal Article

Background: In line with the NICE guidance, an NHS-commissioned case management intervention was provided for individuals receiving Incapacity Benefit payments for ≥3 years in the North East of England. The intervention aimed to improve the health of... Read More about Prospective pilot evaluation of the effectiveness and cost-utility of a "health first" case management service for long-term Incapacity Benefit recipients.

Prophylactic Antibiotics to Prevent Cellulitis of the Leg: Economic Analysis of the PATCH I & II Trials (2014)
Journal Article

Background: Cellulitis (erysipelas) is a recurring and debilitating bacterial infection of the skin and underlying tissue. We assessed the cost-effectiveness of prophylactic antibiotic treatment to prevent the recurrence of cellulitis using low dose... Read More about Prophylactic Antibiotics to Prevent Cellulitis of the Leg: Economic Analysis of the PATCH I & II Trials.