Crystal structure of the BREX phage defence protein BrxA

Beck, I.N.; Picton, D.M.; Blower, T.R.

doi:10.1016/j.crstbi.2022.06.001

All Outputs (2)

Toxin release by conditional remodelling of ParDE1 from Mycobacterium tuberculosis leads to gyrase inhibition (2023)
Journal Article
Beck, I. N., Arrowsmith, T. J., Grobbelaar, M. J., Bromley, E. C., Marles-Wright, J., & Blower, T. R. (2024). Toxin release by conditional remodelling of ParDE1 from Mycobacterium tuberculosis leads to gyrase inhibition. Nucleic Acids Research, 52(4), 1909-1929. https://doi.org/10.1093/nar/gkad1220

Mycobacterium tuberculosis, the causative agent of tuberculosis, is a growing threat to global health, with recent efforts towards its eradication being reversed in the wake of the COVID-19 pandemic. Increasing resistance to gyrase-targeting second-l... Read More about Toxin release by conditional remodelling of ParDE1 from Mycobacterium tuberculosis leads to gyrase inhibition.

Crystal structure of the BREX phage defence protein BrxA (2022)
Journal Article
Beck, I., Picton, D., & Blower, T. (online). Crystal structure of the BREX phage defence protein BrxA. Current Research in Structural Biology, https://doi.org/10.1016/j.crstbi.2022.06.001

Bacteria are constantly challenged by bacteriophage (phage) infection and have developed multitudinous and varied resistance mechanisms. Bacteriophage Exclusion (BREX) systems protect from phage infection by generating methylation patterns at non-pal... Read More about Crystal structure of the BREX phage defence protein BrxA.