All Outputs (3)

Nerve injury-induced changes in Homer/glutamate receptor signaling contribute to the development and maintenance of neuropathic pain (2013)
Journal Article
Obara, I., Goulding, S., Hu, J., Klugmann, M., Worley, P., & Szumlinski, K. (2013). Nerve injury-induced changes in Homer/glutamate receptor signaling contribute to the development and maintenance of neuropathic pain. PAIN, 154(10), 1932-1945. https://doi.org/10.1016/j.pain.2013.03.035

While group 1 metabotropic glutamate receptors (mGluRs) and ionotropic N-methyl-d-aspartate (NMDA) receptors regulate nociception, the precise molecular mechanism(s) contributing to glutamate signaling in chronic pain remain unclear. Here we not only... Read More about Nerve injury-induced changes in Homer/glutamate receptor signaling contribute to the development and maintenance of neuropathic pain.

Synthetic self-assembling clostridial chimera for modulation of sensory functions (2013)
Journal Article
Ferrari, E., Gu, C., Niranjan, D., Restani, L., Rasetti-Escargueil, C., Obara, I., …Davletov, B. (2013). Synthetic self-assembling clostridial chimera for modulation of sensory functions. Bioconjugate Chemistry, 24(10), 1750-1759. https://doi.org/10.1021/bc4003103

Clostridial neurotoxins reversibly block neuronal communication for weeks and months. While these proteolytic neurotoxins hold great promise for clinical applications and the investigation of brain function, their paralytic activity at neuromuscular... Read More about Synthetic self-assembling clostridial chimera for modulation of sensory functions.

Homers at the Interface between Reward and Pain (2013)
Journal Article
Obara, I., Goulding, S., Gould, A., Lominac, K., Hu, J., Zhang, P., …Szumlinski, K. (2013). Homers at the Interface between Reward and Pain. Frontiers in Psychiatry, 4, https://doi.org/10.3389/fpsyt.2013.00039

Pain alters opioid reinforcement, presumably via neuroadaptations within ascending pain pathways interacting with the limbic system. Nerve injury increases expression of glutamate receptors and their associated Homer scaffolding proteins throughout t... Read More about Homers at the Interface between Reward and Pain.