All Outputs (2)

CAP2, cyclase-associated protein 2, is a dual compartment protein (2007)
Journal Article
Peche, V., Shekar, S., Leichter, M., Korte, H., Schroder, R., Schleicher, M., …Noegel, A. (2007). CAP2, cyclase-associated protein 2, is a dual compartment protein. Cellular and Molecular Life Sciences, 64(19-20), 2702-15

Cyclase-associated proteins (CAPs) are evolutionarily conserved proteins with roles in regulating the actin cytoskeleton and in signal transduction. Mammals have two CAP genes encoding the related CAP1 and CAP2. We studied the distribution and subcel... Read More about CAP2, cyclase-associated protein 2, is a dual compartment protein.

Nesprin-2 giant safeguards nuclear envelope architecture in LMNA S143F progeria cells (2007)
Journal Article
Kandert, S., Luke, Y., Kleinhenz, T., Neumann, S., Lu, W., Jaeger, V., …Karakesisoglou, I. (2007). Nesprin-2 giant safeguards nuclear envelope architecture in LMNA S143F progeria cells. Human Molecular Genetics, 16(23), 2944-2959. https://doi.org/10.1093/hmg/ddm255

The S143F lamin A/C point mutation causes a phenotype combining features of myopathy and progeria. We demonstrate here that patient dermal fibroblast cells have dysmorphic nuclei containing numerous blebs and lobulations, which progressively accumula... Read More about Nesprin-2 giant safeguards nuclear envelope architecture in LMNA S143F progeria cells.