All Outputs (4)

HFO-1234yf as a CF3-building block: Synthesis and Chemistry of CF­3-ynones (2020)
Journal Article
Murray, B. J., Marsh, T. G., Yufit, D. S., Fox, M. A., Harsanyi, A., Boulton, L. T., & Sandford, G. (2020). HFO-1234yf as a CF3-building block: Synthesis and Chemistry of CF­3-ynones. European Journal of Organic Chemistry, 2020(39), 6236-6244. https://doi.org/10.1002/ejoc.202001071

Reaction of low cost, readily available 4th generation refrigerant gas 2,3,3,3‐tetrafluoropropene (HFO‐1234yf) with lithium diisopropylamide (LDA) leads to formation of lithium 3,3,3‐trifluoropropynide, addition of which to a range of aldehydes forme... Read More about HFO-1234yf as a CF3-building block: Synthesis and Chemistry of CF­3-ynones.

Kinetics of electrophilic fluorination of steroids and epimerisation of fluorosteroids (2020)
Journal Article
Rozatian, N., Harsanyi, A., Murray, B. J., Hampton, A. S., Chin, E. J., Cook, A. S., …Sandford, G. (2020). Kinetics of electrophilic fluorination of steroids and epimerisation of fluorosteroids. Chemistry - A European Journal, 26(52), 12027-12035. https://doi.org/10.1002/chem.202001120

Fluorinated steroids, which are synthesised by electrophilic fluorination, form a significant proportion of marketed pharmaceuticals. To gain quantitative information on fluorination at the 6‐position of steroids, we conducted kinetics studies on eno... Read More about Kinetics of electrophilic fluorination of steroids and epimerisation of fluorosteroids.

a-Fluorotricarbonyl derivatives as versatile fluorinated building blocks: synthesis of fluoro-acetophenone, fluoro-ketoester and fluoro-pyran-4-one derivatives (2020)
Journal Article
Harsanyi, A., Luckener, A., Pasztor, H., Yilmaz, Z., Tam, L., Yufit, D., & Sandford, G. (2020). a-Fluorotricarbonyl derivatives as versatile fluorinated building blocks: synthesis of fluoro-acetophenone, fluoro-ketoester and fluoro-pyran-4-one derivatives. European Journal of Organic Chemistry, 2020(25), 3872-3878. https://doi.org/10.1002/ejoc.202000503

Fluorinated acyl‐Meldrum’s acid derivatives were synthesised by electrophilic fluorination of appropriate phenacyl Meldrum’s acid substrates using Selectfluor. Reactions with water, ethanol, Grignard and alkynyl lithium reagents gave rise to the corr... Read More about a-Fluorotricarbonyl derivatives as versatile fluorinated building blocks: synthesis of fluoro-acetophenone, fluoro-ketoester and fluoro-pyran-4-one derivatives.

Fluorocyanoesters as Additives for Lithium-Ion Battery Electrolytes (2020)
Journal Article
Walton, J. J., Hiasa, T., Kumita, H., Takeshi, K., & Sandford, G. (2020). Fluorocyanoesters as Additives for Lithium-Ion Battery Electrolytes. ACS Applied Materials and Interfaces, 12(13), 15893-15902. https://doi.org/10.1021/acsami.9b23028

A range of methyl 2-fluorocyanoester derivatives were synthesized from dimethyl 2-fluoromalonate ester, and their efficacy as additives in lithium-ion battery (LIB) electrolytes was determined. The role played by the 2-fluorocyanoester additives on b... Read More about Fluorocyanoesters as Additives for Lithium-Ion Battery Electrolytes.