Cellular and molecular mechanisms for the synergistic cytotoxicity elicited by oxaliplatin and pemetrexed in colon cancer cell lines

Nannizzi, Sara; Veal, Gareth J.; Giovannetti, Elisa; Mey, Valentina; Ricciardi, Simona; Ottley Christopher, J.; Del Tacca, Mario; Danesi, Romano

doi:10.1007/s00280-009-1195-2

All Outputs (5)

Mixed fluid sources involved in diamond growth constrained by Sr-Nd-Pb-C-N isotopes and trace elements (2010)
Journal Article
Klein-BenDavid, O., Pearson, D., Nowell, G., Ottley, C., McNeill, J., & Cartigny, P. (2010). Mixed fluid sources involved in diamond growth constrained by Sr-Nd-Pb-C-N isotopes and trace elements. Earth and Planetary Science Letters, 289(1-2), 123-133. https://doi.org/10.1016/j.epsl.2009.10.035

From source to crust: Tracing magmatic evolution in a kimberlite and a melilitite using microsample geochemistry. (2010)
Journal Article
Malarkey, J., Pearson, D., Kjarsgaard, B., Davidson, J., Nowell, G., Ottley, C., & Stammer, J. (2010). From source to crust: Tracing magmatic evolution in a kimberlite and a melilitite using microsample geochemistry. Earth and Planetary Science Letters, 299(1-2), 80-90. https://doi.org/10.1016/j.epsl.2010.08.020

We present an integrated microsampling trace element and isotopic study of primary minerals within the Jos kimberlite, Canada, in order to observe how different phases record progressive crustal interaction in the evolving kimberlite. Identification... Read More about From source to crust: Tracing magmatic evolution in a kimberlite and a melilitite using microsample geochemistry..

Formation of the North Atlantic Craton: Timing and mechanisms constrained from Re-Os isotope and PGE data of peridotite xenoliths from SW Greenland (2010)
Journal Article
Wittig, N., Webb, M., Pearson, D., Dale, C., Ottley, C., Hutchison, M., …Luguet, A. (2010). Formation of the North Atlantic Craton: Timing and mechanisms constrained from Re-Os isotope and PGE data of peridotite xenoliths from SW Greenland. Chemical Geology, 276(3-4), 166-187. https://doi.org/10.1016/j.chemgeo.2010.06.002

Podiform chromitites and mantle peridotites of the Antalya ophiolite, Isparta Angle (SW Turkey): Implications for partial melting and melt-rock interaction in oceanic and subduction-related settings. (2010)
Journal Article
Caran, S., Coban, H., Flower, M. F., Ottley, C., & Yilmaz, K. (2010). Podiform chromitites and mantle peridotites of the Antalya ophiolite, Isparta Angle (SW Turkey): Implications for partial melting and melt-rock interaction in oceanic and subduction-related settings. Lithos, 114(3-4), 307-326. https://doi.org/10.1016/j.lithos.2009.09.006

Cellular and molecular mechanisms for the synergistic cytotoxicity elicited by oxaliplatin and pemetrexed in colon cancer cell lines (2010)
Journal Article
Nannizzi, S., Veal, G. J., Giovannetti, E., Mey, V., Ricciardi, S., Ottley Christopher, J., …Danesi, R. (2010). Cellular and molecular mechanisms for the synergistic cytotoxicity elicited by oxaliplatin and pemetrexed in colon cancer cell lines. Cancer Chemotherapy and Pharmacology, 66(3), 547-558. https://doi.org/10.1007/s00280-009-1195-2

Purpose: Oxaliplatin effect in the treatment of colorectal cancer is improved upon combination with thymidylate synthase (TS) inhibitors. Pemetrexed is polyglutamated by the folylpolyglutamate synthase (FPGS) and blocks folate metabolism and DNA synt... Read More about Cellular and molecular mechanisms for the synergistic cytotoxicity elicited by oxaliplatin and pemetrexed in colon cancer cell lines.