Contribution of HIF-1 and drug penetrance to oxaliplatin resistance in hypoxic colorectal cancer cells

Roberts, D.L.; Williams, K.J.; Cowen, R.L.; Barathova, M.; Eustace, A.J.; Brittain-Dissont, S.; Tilby, M.J.; Pearson, D.G.; Ottley, C.J.; Stratford, I.J.; Dive, C.

doi:10.1038/sj.bjc.6605311

All Outputs (4)

Quantitative analysis of trace element concentrations in some gem-quality diamonds (2009)
Journal Article
McNeill, J., Pearson, D., Klein-BenDavid, O., Nowell, G., Ottley, C., & Chinn, I. (2009). Quantitative analysis of trace element concentrations in some gem-quality diamonds. Journal of Physics: Condensed Matter, 21(36), https://doi.org/10.1088/0953-8984/21/36/364207

The kinase inhibitor O(6)-cyclohexylmethylguanine (NU2058) potentiates the cytotoxicity of cisplatin by mechanisms that are independent of its effect upon CDK2. (2009)
Journal Article
Harrison, L. R., Ottley, C. J., Pearson, D. G., Roche, C., Wedge, S. R., Dolan, M. E., …Tilby, M. J. (2009). The kinase inhibitor O(6)-cyclohexylmethylguanine (NU2058) potentiates the cytotoxicity of cisplatin by mechanisms that are independent of its effect upon CDK2. Biochemical Pharmacology, 77, 1586-1592. https://doi.org/10.1016/j.bcp.2009.02.018

Combined Sr isotope and trace element analysis of melt inclusions at sub-ng levels using micro-milling, TIMS and ICPMS (2009)
Journal Article
Harlou, R., Pearson, D., Nowell, G., Ottley, C., & Davidson, J. (2009). Combined Sr isotope and trace element analysis of melt inclusions at sub-ng levels using micro-milling, TIMS and ICPMS. Chemical Geology, 260(3-4), 254-268. https://doi.org/10.1016/j.chemgeo.2008.12.020

Contribution of HIF-1 and drug penetrance to oxaliplatin resistance in hypoxic colorectal cancer cells (2009)
Journal Article
Roberts, D., Williams, K., Cowen, R., Barathova, M., Eustace, A., Brittain-Dissont, S., …Dive, C. (2009). Contribution of HIF-1 and drug penetrance to oxaliplatin resistance in hypoxic colorectal cancer cells. British Journal of Cancer, 101(8), 1290-1297. https://doi.org/10.1038/sj.bjc.6605311

Background: Hypoxia is as an indicator of poor treatment outcome. Consistently, hypoxic HCT116 colorectal cancer cells are resistant to oxaliplatin, although the mechanistic basis is unclear. This study sought to investigate the relative contribution... Read More about Contribution of HIF-1 and drug penetrance to oxaliplatin resistance in hypoxic colorectal cancer cells.