The action of all-trans-retinoic acid (ATRA) and synthetic retinoid analogues (EC19 and EC23) on human pluripotent stem cells differentiation investigated using single cell infrared microspectroscopy

Clemens, G.; Flower, K.R.; Henderson, A.P.; Whiting, A.; Przyborski, S.A.; Jimenez-Hernandez, M.; Ball, F.; Bassan, P.; Cinque, G.; Gardner, P.

doi:10.1039/c3mb25505k

All Outputs (5)

Neurogenesis in Response to Synthetic Retinoids at Different Temporal Scales (2017)
Journal Article

All-trans retinoic acid (ATRA) plays key roles in neurogenesis mediated by retinoic acid receptors (RARs). RARs are important targets for the therapeutic regulation of neurogenesis but effective drug development depends on modelling-based strategies... Read More about Neurogenesis in Response to Synthetic Retinoids at Different Temporal Scales.

Application of Synthetic Photostable Retinoids Induces Novel Limb and Facial Phenotypes During Chick Embryogenesis In Vivo (2014)
Journal Article

We have recently developed a range of synthetic retinoid analogues which include the compounds EC23 and EC19. They are stable on exposure to light and are predicted to be resistant to the normal metabolic processes involved in the inactivation of ret... Read More about Application of Synthetic Photostable Retinoids Induces Novel Limb and Facial Phenotypes During Chick Embryogenesis In Vivo.

Design and biological evaluation of synthetic retinoids: Probing length vs. stability vs. activity (2013)
Journal Article

All trans-retinoic acid (ATRA) is widely used to direct the differentiation of cultured stem cells. When exposed to the pluripotent human embryonal carcinoma (EC) stem cell line, TERA2.cl.SP12, ATRA induces ectoderm differentiation and the formation... Read More about Design and biological evaluation of synthetic retinoids: Probing length vs. stability vs. activity.

Synthesis and applications of 2,4-disubstituted thiazoles derivatives as small molecule modulators of cellular development (2013)
Journal Article

Understanding how the structure of molecules relates to their function and biological activity is essential in the development of new analogues with targeted activity. This is especially relevant in mediating developmental processes in mammalian cell... Read More about Synthesis and applications of 2,4-disubstituted thiazoles derivatives as small molecule modulators of cellular development.

The action of all-trans-retinoic acid (ATRA) and synthetic retinoid analogues (EC19 and EC23) on human pluripotent stem cells differentiation investigated using single cell infrared microspectroscopy (2013)
Journal Article

All trans-retinoic acid (ATRA) is widely used to direct the differentiation of cultured stem cells. When exposed to the pluripotent human embryonal carcinoma (EC) stem cell line, TERA2.cl.SP12, ATRA induces ectoderm differentiation and the formation... Read More about The action of all-trans-retinoic acid (ATRA) and synthetic retinoid analogues (EC19 and EC23) on human pluripotent stem cells differentiation investigated using single cell infrared microspectroscopy.