Robert Banks r.w.banks@durham.ac.uk
Academic Visitor
Evidence for activity-dependent modulation of sensory-terminal excitability in spindles by glutamate release from synaptic-like vesicles
Banks, R.W.; Bewick, G.S.; Reid, B.; Richardson, C.
Authors
G.S. Bewick
B. Reid
C. Richardson
Contributors
Simon.C Gandevia
Editor
Uwe Proske
Editor
Douglas.G Stuart
Editor
Abstract
Sensory terminals of muscle spindles and similar mechanosensory neurons contain large numbers of 50 nm, "synaptic-like" vesicles (SLVs), about whose role very little is known. Using fluorescence microscopy, immunocytochemistry and electrophysiological recording, we present evidence that SLVs undergo a recycling process, and that they release glutamate that has an autogenic excitatory effect on mechanosensory transduction, probably involving a metabotropic receptor linked to phospholipase D. The rate of recycling of SLVs is activity dependent, at least in part, as shown by an increased rate of destaining of preparations labelled with FMI-43 during high-frequency, small-amplitude vibration. Immunogold labelling showed levels of glutamate-like reactivity in the sensory terminals at least as great as in probable Ia presynaptic terminals in the spinal cord. Exogenously applied glutamate has an excitatory effect on the spindle's response to stretch, which is blocked by 3,5-dihydroxyphenylglycine.
Citation
Banks, R., Bewick, G., Reid, B., & Richardson, C. (2002). Evidence for activity-dependent modulation of sensory-terminal excitability in spindles by glutamate release from synaptic-like vesicles. In S. Gandevia, U. Proske, & D. Stuart (Eds.), Sensorimotor control of movement and posture (13-18). (2002). Springer Verlag. https://doi.org/10.1007/978-1-4615-0713-0_2
Publication Date | Jan 1, 2002 |
---|---|
Deposit Date | Feb 20, 2008 |
Publisher | Springer Verlag |
Pages | 13-18 |
Series Title | Advances in experimental medicine and biology |
Series Number | 508 |
Edition | 2002 |
Book Title | Sensorimotor control of movement and posture. |
ISBN | 9781461352068 |
DOI | https://doi.org/10.1007/978-1-4615-0713-0_2 |
Related Public URLs | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=12171103 |
You might also like
Immunoelectron Microscopy of Cryofixed Freeze-Substituted Yeast
(2016)
Book Chapter
STING nuclear partners contribute to innate immune signaling responses
(2021)
Journal Article
BBLN-1 is essential for intermediate filament organization and apical membrane morphology
(2021)
Journal Article
Downloadable Citations
About Durham Research Online (DRO)
Administrator e-mail: dro.admin@durham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search