Dr Peter Chivers peter.chivers@durham.ac.uk
Associate Professor
Nickel supports the growth of microbes from a variety of very different growth environments that affect nickel speciation. The mechanisms of nickel uptake and the molecular bases for the selectivity of this process are emerging. The recent surge of Ni-importer protein structures provides an understanding of Ni-recognition in the initial binding step of the import process. This review compares the structural basis for Ni-recognition in the complexes (ABC and ECF-type) that dominate primary (ATP-dependent) transport, with a focus on how the structures suggest mechanisms for Ni selectivity. The structures raise key questions about the mechanisms of nickel-transfer reactions involved in import. There is also a discussion of key experimental approaches necessary to help establish the physiological importance of these structures.
Chivers, P. (2015). Nickel recognition by bacterial importer proteins. Metallomics, 7(4), 590-595. https://doi.org/10.1039/c4mt00310a
Journal Article Type | Article |
---|---|
Acceptance Date | Jan 20, 2015 |
Publication Date | Apr 20, 2015 |
Deposit Date | Jan 30, 2015 |
Publicly Available Date | Feb 10, 2015 |
Journal | Metallomics |
Print ISSN | 1756-5901 |
Electronic ISSN | 1756-591X |
Publisher | Oxford University Press |
Peer Reviewed | Peer Reviewed |
Volume | 7 |
Issue | 4 |
Pages | 590-595 |
DOI | https://doi.org/10.1039/c4mt00310a |
Public URL | https://durham-repository.worktribe.com/output/1413422 |
Accepted Journal Article
(2.2 Mb)
PDF
Protein metalation in biology
(2021)
Journal Article
Bacterial sensors define intracellular free energies for correct enzyme metalation
(2019)
Journal Article
The mechanism of a formaldehyde-sensing transcriptional regulator
(2016)
Journal Article
About Durham Research Online (DRO)
Administrator e-mail: dro.admin@durham.ac.uk
This application uses the following open-source libraries:
Apache License Version 2.0 (http://www.apache.org/licenses/)
Apache License Version 2.0 (http://www.apache.org/licenses/)
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search