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Nickel recognition by bacterial importer proteins

Chivers, P.T.

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Nickel supports the growth of microbes from a variety of very different growth environments that affect nickel speciation. The mechanisms of nickel uptake and the molecular bases for the selectivity of this process are emerging. The recent surge of Ni-importer protein structures provides an understanding of Ni-recognition in the initial binding step of the import process. This review compares the structural basis for Ni-recognition in the complexes (ABC and ECF-type) that dominate primary (ATP-dependent) transport, with a focus on how the structures suggest mechanisms for Ni selectivity. The structures raise key questions about the mechanisms of nickel-transfer reactions involved in import. There is also a discussion of key experimental approaches necessary to help establish the physiological importance of these structures.

Journal Article Type Article
Acceptance Date Jan 20, 2015
Publication Date Apr 20, 2015
Deposit Date Jan 30, 2015
Publicly Available Date Feb 10, 2015
Journal Metallomics
Print ISSN 1756-5901
Electronic ISSN 1756-591X
Publisher Oxford University Press
Peer Reviewed Peer Reviewed
Volume 7
Issue 4
Pages 590-595
Public URL


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