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Outputs (3)

Hydration Behavior of Polylactam Clathrate Hydrate Inhibitors and Their Small-Molecule Model Compounds (2017)
Journal Article
Perrin, A., Goodwin, M. J., Musa, O. M., Berry, D. J., Corner, P., Edkins, K., …Steed, J. W. (2017). Hydration Behavior of Polylactam Clathrate Hydrate Inhibitors and Their Small-Molecule Model Compounds. Crystal Growth and Design, 17(6), 3236-3249. https://doi.org/10.1021/acs.cgd.7b00221

The solution hydration behavior of a series of lactam-based kinetic clathrate hydrate inhibitors (KHIs) has been studied in order to determine mechanistic insight into their KHI performance. IR and 1H NMR spectroscopic titration data were compared ac... Read More about Hydration Behavior of Polylactam Clathrate Hydrate Inhibitors and Their Small-Molecule Model Compounds.

Pharmaceutical cocrystals, salts and multicomponent systems; intermolecular interactions and property based design (2017)
Journal Article
Berry, D. J., & Steed, J. W. (2017). Pharmaceutical cocrystals, salts and multicomponent systems; intermolecular interactions and property based design. Advanced Drug Delivery Reviews, 117, 3-24. https://doi.org/10.1016/j.addr.2017.03.003

As small molecule drugs become harder to develop and less cost effective for patient use, efficient strategies for their property improvement become increasingly important to global health initiatives. Improvements in the physical properties of Activ... Read More about Pharmaceutical cocrystals, salts and multicomponent systems; intermolecular interactions and property based design.

Stabilisation of an amorphous form of ROY through a predicted co-former interaction (2016)
Journal Article
Corner, P. A., Harburn, J. J., Steed, J. W., McCabe, J. F., & Berry, D. J. (2016). Stabilisation of an amorphous form of ROY through a predicted co-former interaction. Chemical Communications, 52(39), 6537-6540. https://doi.org/10.1039/c6cc02949c

The highly polymorphic compound ROY, notorious for the colour of its crystals, was the subject of an optimised high-throughput ultrasound-based co-crystal screen. This screen involved a computational pre-screen which highlighted an interaction betwee... Read More about Stabilisation of an amorphous form of ROY through a predicted co-former interaction.