Outputs (4)

Flicker-assisted localization microscopy reveals altered mitochondrial architecture in hypertension (2015)
Journal Article
Chalmers, S., Saunter, C. D., Girkin, J. M., & McCarron, J. G. (2015). Flicker-assisted localization microscopy reveals altered mitochondrial architecture in hypertension. Scientific Reports, 5, Article 16875. https://doi.org/10.1038/srep16875

Mitochondrial morphology is central to normal physiology and disease development. However, in many live cells and tissues, complex mitochondrial structures exist and morphology has been difficult to quantify. We have measured the shape of electricall... Read More about Flicker-assisted localization microscopy reveals altered mitochondrial architecture in hypertension.

Pressure-dependent regulation of Ca2+ signalling in the vascular endothelium (2015)
Journal Article
Wilson, C., Saunter, C. D., Girkin, J. M., & McCarron, J. G. (2015). Pressure-dependent regulation of Ca2+ signalling in the vascular endothelium. The Journal of Physiology, 593(24), 5231-5253. https://doi.org/10.1113/jp271157

The endothelium is an interconnected network upon which haemodynamic mechanical forces act to control vascular tone and remodelling in disease. Ca2+ signalling is central to the endothelium's mechanotransduction and networked activity. However, chall... Read More about Pressure-dependent regulation of Ca2+ signalling in the vascular endothelium.

A dimensionless ordered pull-through model of the mammalian lens epithelium evidences scaling across species and explains the age-dependent changes in cell density in the human lens (2015)
Journal Article
Wu, J., Wu, W., Tholozan, F., Saunter, C., Girkin, J., & Quinlan, R. (2015). A dimensionless ordered pull-through model of the mammalian lens epithelium evidences scaling across species and explains the age-dependent changes in cell density in the human lens. Journal of the Royal Society. Interface, 12(108), https://doi.org/10.1098/rsif.2015.0391

We present a mathematical (ordered pull-through; OPT) model of the cell-density profile for the mammalian lens epithelium together with new experimental data. The model is based upon dimensionless parameters, an important criterion for inter-species... Read More about A dimensionless ordered pull-through model of the mammalian lens epithelium evidences scaling across species and explains the age-dependent changes in cell density in the human lens.

Realtime wavefront sensing in a SPIM microscope, and active aberration tracking (2015)
Presentation / Conference Contribution
Taylor, J. M., Saunter, C. D., Bourgenot, C., Girkin, J. M., & Love, G. D. (2015, February). Realtime wavefront sensing in a SPIM microscope, and active aberration tracking. Presented at Adaptive Optics and Wavefront Control for Biological Systems, San Francisco, CA

Adaptive optics (AO) can potentially allow high resolution imaging deep inside living tissue, mitigating against the loss of resolution due to aberrations caused by overlying tissue. Closed-loop AO correction is particularly attractive for moving tis... Read More about Realtime wavefront sensing in a SPIM microscope, and active aberration tracking.