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Dr David Doupe's Outputs (11)

Drosophila intestinal stem and progenitor cells are major sources and regulators of homeostatic niche signals (2018)
Journal Article
Doupé, D., Marshall, O., Dayton, H., Brand, A., & Perrimon, N. (2018). Drosophila intestinal stem and progenitor cells are major sources and regulators of homeostatic niche signals. Proceedings of the National Academy of Sciences, 115(48), 12218-12223. https://doi.org/10.1073/pnas.1719169115

Epithelial homeostasis requires the precise balance of epithelial stem/progenitor proliferation and differentiation. While many signaling pathways that regulate epithelial stem cells have been identified, it is probable that other regulators remain u... Read More about Drosophila intestinal stem and progenitor cells are major sources and regulators of homeostatic niche signals.

Quantitative 3D analysis of complex single border cell behaviors in coordinated collective cell migration (2017)
Journal Article
Cliffe, A., Doupé, D. P., Sung, H., Lim, I. K. H., Ong, K. H., Cheng, L., & Yu, W. (2017). Quantitative 3D analysis of complex single border cell behaviors in coordinated collective cell migration. Nature Communications, 8, Article 14905. https://doi.org/10.1038/ncomms14905

Understanding the mechanisms of collective cell migration is crucial for cancer metastasis, wound healing and many developmental processes. Imaging a migrating cluster in vivo is feasible, but the quantification of individual cell behaviours remains... Read More about Quantitative 3D analysis of complex single border cell behaviors in coordinated collective cell migration.

Visualizing and Manipulating Temporal Signaling Dynamics with Fluorescence-Based Tools (2014)
Journal Article
Doupé, D., & Perrimon, N. (2014). Visualizing and Manipulating Temporal Signaling Dynamics with Fluorescence-Based Tools. Science Signaling, 7(319), https://doi.org/10.1126/scisignal.2005077

The use of genome-wide proteomic and RNA interference approaches has moved our understanding of signal transduction from linear pathways to highly integrated networks centered on core nodes. However, probing the dynamics of flow of information throug... Read More about Visualizing and Manipulating Temporal Signaling Dynamics with Fluorescence-Based Tools.