1,4-Benzodiazepines as inhibitors of respiratory syncytial virus

Carter, M.C.; Alber, D.G.; Baxter, R.C.; Bithell, S.K.; Budworth, J.; Chubb, A.; Cockerill, G.S.; Dowdell, V.C.L.; Henderson, E.A.; Keegan, S.J.; Kelsey, R.D.; Lockyer, M.J.; Stables, J.N.; Wilson, L.J.; Powell, K.L.

doi:10.1021/jm051185t

All Outputs (2)

Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes (2008)
Journal Article
Angell, R., Angell, T., Bamborough, P., Bamford, M., Chung, C., Cockerill, G., …Walker, A. (2008). Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes. Bioorganic and Medicinal Chemistry Letters, 18(15), 4433-4437. https://doi.org/10.1016/j.bmcl.2008.06.028

The biphenyl amides (BPAs) are a series of p38α MAP kinase inhibitors. Compounds are able to bind to the kinase in either the DFG-in or DFG-out conformation, depending on substituents. X-ray, binding, kinetic and cellular data are shown, providing th... Read More about Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes.

1,4-Benzodiazepines as inhibitors of respiratory syncytial virus (2006)
Journal Article
Carter, M., Alber, D., Baxter, R., Bithell, S., Budworth, J., Chubb, A., …Powell, K. (2006). 1,4-Benzodiazepines as inhibitors of respiratory syncytial virus. Journal of Medicinal Chemistry, 49(7), 2311-2319. https://doi.org/10.1021/jm051185t

Respiratory syncytial virus (RSV) is the cause of one-fifth of all lower respiratory tract infections worldwide and is increasingly being recognized as a serious threat to patient groups with poorly functioning immune systems. Our approach to finding... Read More about 1,4-Benzodiazepines as inhibitors of respiratory syncytial virus.