All Outputs (2)

Radiation-induced DNA Damage and Repair in Lens Epithelial Cells of both Ptch1(+/–) and Ercc2(+/–) Mutated Mice (2021)
Journal Article
Barnard, S., McCarron, R., Mancuso, M., De Stefano, I., Pazzaglia, S., Pawliczek, D., Dalke, C., & Ainsbury, E. (2022). Radiation-induced DNA Damage and Repair in Lens Epithelial Cells of both Ptch1(+/–) and Ercc2(+/–) Mutated Mice. Radiation research, 197(1), 36-42. https://doi.org/10.1667/rade-20-00264.1

Epidemiological studies suggest an increased incidence and risk of cataract after low-dose (<2 Gy) ionizing radiation exposures. However, the biological mechanism(s) of this process are not fully understood. DNA damage and repair are thought to have...

Inverse dose-rate effect of ionising radiation on residual 53BP1 foci in the eye lens (2019)
Journal Article
Barnard, S., McCarron, R., Moquet, J., Quinlan, R., & Ainsbury, E. (2019). Inverse dose-rate effect of ionising radiation on residual 53BP1 foci in the eye lens. Scientific Reports, 9, Article 10418. https://doi.org/10.1038/s41598-019-46893-3

The influence of dose rate on radiation cataractogenesis has yet to be extensively studied. One recent epidemiological investigation suggested that protracted radiation exposure increases radiation-induced cataract risk: cumulative doses of radiation... Read More about Inverse dose-rate effect of ionising radiation on residual 53BP1 foci in the eye lens.