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Concussion-Related Biomarker Variations in Retired Rugby Players and Implications for Neurodegenerative Disease Risk: The UK Rugby Health Study (2024)
Journal Article
Alanazi, N., Fitzgerald, M., Hume, P., Hellewell, S., Horncastle, A., Anyaegbu, C., Papini, M. G., Hargreaves, N., Halicki, M., Entwistle, I., Hind, K., & Chazot, P. (2024). Concussion-Related Biomarker Variations in Retired Rugby Players and Implications for Neurodegenerative Disease Risk: The UK Rugby Health Study. International Journal of Molecular Sciences, 25(14), Article 7811. https://doi.org/10.3390/ijms25147811

The health and well-being of retired rugby union and league players, particularly regarding the long-term effects of concussions, are of major concern. Concussion has been identified as a major risk factor for neurodegenerative diseases, such as Alzh... Read More about Concussion-Related Biomarker Variations in Retired Rugby Players and Implications for Neurodegenerative Disease Risk: The UK Rugby Health Study.

Evaluation of the anti-nociceptive profile of essential oil from Melissa officinalis L. (lemon balm) in acute and chronic pain models (2023)
Journal Article
Chindo, B. A., Howes, M. R., Abuhamdah, S., Mallam, D., Micah, T., Awotula, R. I., …Chazot, P. L. (2024). Evaluation of the anti-nociceptive profile of essential oil from Melissa officinalis L. (lemon balm) in acute and chronic pain models. Journal of Ethnopharmacology, 321, Article 117500. https://doi.org/10.1016/j.jep.2023.117500

Ethnopharmacological relevance
Melissa officinalis L. (Lamiaceae) is a medicinal plant native to Mediterranean regions and found in other parts of the world. Extracts and essential oil from this widely cultivated culinary medicinal herb are used in... Read More about Evaluation of the anti-nociceptive profile of essential oil from Melissa officinalis L. (lemon balm) in acute and chronic pain models.

Attenuation of Vanadium-Induced Neurotoxicity in Rat Hippocampal Slices (In Vitro) and Mice (In Vivo) by ZA-II-05, a Novel NMDA-Receptor Antagonist (2023)
Journal Article
Digal Ladagu, A., Eniola Olopade, F., Chazot, P., Oyagbemi, A. A., Ohiomokhare, S., Racheal Folarin, O., …Olopade, J. O. (2023). Attenuation of Vanadium-Induced Neurotoxicity in Rat Hippocampal Slices (In Vitro) and Mice (In Vivo) by ZA-II-05, a Novel NMDA-Receptor Antagonist. International Journal of Molecular Sciences, 24(23), Article 16710. https://doi.org/10.3390/ijms242316710

Exposure to heavy metals, such as vanadium, poses an ongoing environmental and health threat, heightening the risk of neurodegenerative disorders. While several compounds have shown promise in mitigating vanadium toxicity, their efficacy is limited.... Read More about Attenuation of Vanadium-Induced Neurotoxicity in Rat Hippocampal Slices (In Vitro) and Mice (In Vivo) by ZA-II-05, a Novel NMDA-Receptor Antagonist.

Confidence of practitioners to support self-management of pain: A multidisciplinary survey (2023)
Journal Article
Penlington, C., Pornsukjantra, P., Chazot, P., Cole, F., & Denneny, D. (2024). Confidence of practitioners to support self-management of pain: A multidisciplinary survey. British Journal of Pain, 18(2), 148-154. https://doi.org/10.1177/20494637231212748

Background: Supported self-management is an important component of management for persistent pain according to current recommendations and guidelines. However, it is unclear whether staff from differing disciplines who may be in early contact with pe... Read More about Confidence of practitioners to support self-management of pain: A multidisciplinary survey.

Blood-Based Biomarkers in the Diagnosis of Chronic Traumatic Encephalopathy: Research to Date and Future Directions (2023)
Journal Article
Halicki, M. J., Hind, K., & Chazot, P. L. (2023). Blood-Based Biomarkers in the Diagnosis of Chronic Traumatic Encephalopathy: Research to Date and Future Directions. International Journal of Molecular Sciences, 24(16), Article 12556. https://doi.org/10.3390/ijms241612556

Chronic Traumatic Encephalopathy (CTE) is a neurodegenerative disease consistently associated with repetitive traumatic brain injuries (TBIs), which makes multiple professions, such as contact sports athletes and the military, especially susceptible... Read More about Blood-Based Biomarkers in the Diagnosis of Chronic Traumatic Encephalopathy: Research to Date and Future Directions.

Pain through the perspective of art and creativity: insights from the Unmasking Pain project (2023)
Journal Article
Johnson, M. I., Chazot, P., Cole, F., Cruickshank, R., Fuller, D., Keyse, C., …Woodall, J. (2023). Pain through the perspective of art and creativity: insights from the Unmasking Pain project. Frontiers in Pain Research, 4, Article 1179116. https://doi.org/10.3389/fpain.2023.1179116

People struggle to tell their story of living with pain and when they do it is articulated in a way that may not be understood, heard or taken seriously. Unmasking Pain is an artist-led project that explored creative approaches to tell stories of lif... Read More about Pain through the perspective of art and creativity: insights from the Unmasking Pain project.

Histamine receptors in GtoPdb v.2023.1 (2023)
Journal Article
Chazot, P., Cowart, M., Fukui, H., Ganellin, C. R., Gutzmer, R., Haas, H. L., …Young, J. M. (2023). Histamine receptors in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE, 2023(1), https://doi.org/10.2218/gtopdb/f33/2023.1

Histamine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Histamine Receptors [80, 174]) are activated by the endogenous ligand histamine. Marked species differences exist between histamine receptor orthologues [80]. The human and... Read More about Histamine receptors in GtoPdb v.2023.1.

Machine Learning based Biological Ageing Estimation: A Survey (2022)
Book Chapter
Zhang, Z., Jiang, R., Crookes, D., & Chazot, P. (2022). Machine Learning based Biological Ageing Estimation: A Survey. In R. Jiang, L. Zhang, H.-L. Wei, D. Crookes, & P. Chazot (Eds.), Recent Advances in AI-enabled Automated Medical Diagnosis. Routledge

EEG-based Deep Emotional Diagnosis: A Comparative Study (2022)
Book Chapter
Liu, G., Zhang, Z., Jiang, R., Crookes, D., & Chazot, P. (2022). EEG-based Deep Emotional Diagnosis: A Comparative Study. In R. Jiang, L. Zhang, H. Wei, D. Crookes, & P. Chazot (Eds.), Recent Advances in AI-enabled Automated Medical Diagnosis. Routledge. https://doi.org/10.1201/9781003176121

Emotion is an important part of people's daily life, particularly relevant to the mental health of people. Emotional diagnosis is closely related to the nervous system, which can well reflect people's mental conditions in response to the surrounding... Read More about EEG-based Deep Emotional Diagnosis: A Comparative Study.

Recent Advances in AI-enabled Automated Medical Diagnosis (2022)
Book
Jiang, R., Zhang, L., Wei, H., Crookes, D., & Chazot, P. (Eds.). (2022). Recent Advances in AI-enabled Automated Medical Diagnosis. Routledge

Developments in deep learning in the past decade have led to phenomenal growth in AI-based automated medical diagnosis, opening a door to a new era of both medical research and medical industry. It is a golden age for researchers involved in the deve... Read More about Recent Advances in AI-enabled Automated Medical Diagnosis.

Robust Brain Age Estimation based on sMRI via Nonlinear Age-Adaptive Ensemble Learning (2022)
Journal Article
Zhang, Z., Jiang, R., Zhang, C., Williams, B., Jiang, Z., Li, C., …Beghdadi, A. (2022). Robust Brain Age Estimation based on sMRI via Nonlinear Age-Adaptive Ensemble Learning. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 30, 2146-2156. https://doi.org/10.1109/tnsre.2022.3190467

Precise prediction on brain age is urgently needed by many biomedical areas including mental rehabilitation prognosis as well as various medicine or treatment trials. People began to realize that contrasting physical (real) age and predicted brain ag... Read More about Robust Brain Age Estimation based on sMRI via Nonlinear Age-Adaptive Ensemble Learning.

Rationale for 1068 nm Photobiomodulation Therapy (PBMT) as a Novel, Non-Invasive Treatment for COVID-19 and Other Coronaviruses: Roles of NO and Hsp70 (2022)
Journal Article
Kitchen, L. C., Berman, M., Halper, J., & Chazot, P. (2022). Rationale for 1068 nm Photobiomodulation Therapy (PBMT) as a Novel, Non-Invasive Treatment for COVID-19 and Other Coronaviruses: Roles of NO and Hsp70. International Journal of Molecular Sciences, 23(9), Article 5221. https://doi.org/10.3390/ijms23095221

Researchers from across the world are seeking to develop effective treatments for the ongoing coronavirus disease 2019 (COVID-19) outbreak, which arose as a major public health issue in 2019, and was declared a pandemic in early 2020. The pro-inflamm... Read More about Rationale for 1068 nm Photobiomodulation Therapy (PBMT) as a Novel, Non-Invasive Treatment for COVID-19 and Other Coronaviruses: Roles of NO and Hsp70.

Carol's journey in critical care: An Enlighten Project case study (2022)
Journal Article
Mcauley, E., Johnston, L., Johnston, P., Shaw, J., Bonner, S., & Chazot, P. L. (2022). Carol's journey in critical care: An Enlighten Project case study. Trends in Anaesthesia and Critical Care, 44, 3-7. https://doi.org/10.1016/j.tacc.2022.03.001

Background: The Enlighten Project seeks to explore how awareness of the physical environment in critical care may impact patient well-being and recovery and whether simple changes may improve outcomes. Methods: In this study we follow the journey of... Read More about Carol's journey in critical care: An Enlighten Project case study.

Phenotypical Screening on Neuronal Plasticity in Hippocampal-Prefrontal Cortex Connectivity Reveals an Antipsychotic with a Novel Profile (2022)
Journal Article
Spedding, M., Sebban, C., Jay, T. M., Rocher, C., Tesolin-Decros, B., Chazot, P., …Gacsályi, I. (2022). Phenotypical Screening on Neuronal Plasticity in Hippocampal-Prefrontal Cortex Connectivity Reveals an Antipsychotic with a Novel Profile. Cells, 11(7), Article 1181. https://doi.org/10.3390/cells11071181

Dysfunction in the hippocampus-prefrontal cortex (H-PFC) circuit is a critical determinant of schizophrenia. Screening of pyridazinone-risperidone hybrids on this circuit revealed EGIS 11150 (S 36549). EGIS 11150 induced theta rhythm in hippocampal s... Read More about Phenotypical Screening on Neuronal Plasticity in Hippocampal-Prefrontal Cortex Connectivity Reveals an Antipsychotic with a Novel Profile.

Votucalis, a Novel Centrally Sparing Histamine-Binding Protein, Attenuates Histaminergic Itch and Neuropathic Pain in Mice (2022)
Journal Article
Alrashdi, I., Alsubaiyel, A., Chan, M., Battell, E. E., Ennaceur, A., Nunn, M. A., …Obara, I. (2022). Votucalis, a Novel Centrally Sparing Histamine-Binding Protein, Attenuates Histaminergic Itch and Neuropathic Pain in Mice. Frontiers in Pharmacology, 13, Article 846683. https://doi.org/10.3389/fphar.2022.846683

Votucalis is a biologically active protein in tick (R. appendiculatus) saliva, which specifically binds histamine with high affinity and, therefore, has the potential to inhibit the host’s immunological responses at the feeding site. We hypothesized... Read More about Votucalis, a Novel Centrally Sparing Histamine-Binding Protein, Attenuates Histaminergic Itch and Neuropathic Pain in Mice.

Private Facial Prediagnosis as an Edge Service for Parkinson's DBS Treatment Valuation (2022)
Journal Article
Jiang, R., Chazot, P., Pavese, N., Crookes, D., Bouridane, A., & Celebi, M. E. (2022). Private Facial Prediagnosis as an Edge Service for Parkinson's DBS Treatment Valuation. IEEE Journal of Biomedical and Health Informatics, 26(6), 2703-2713. https://doi.org/10.1109/jbhi.2022.3146369

Facial phenotyping for medical prediagnosis has recently been successfully exploited as a novel way for the preclinical assessment of a range of rare genetic diseases, where facial biometrics is revealed to have rich links to underlying genetic or me... Read More about Private Facial Prediagnosis as an Edge Service for Parkinson's DBS Treatment Valuation.

CNS-Sparing Histamine H3 Receptor Antagonist as a Candidate to Prevent the Diabetes-Associated Gastrointestinal Symptoms (2022)
Journal Article
Rosa, A. C., Nardini, P., Sgambellone, S., Gurrieri, M., Spampinato, S. F., Dell’Accio, A., …Pini, A. (2022). CNS-Sparing Histamine H3 Receptor Antagonist as a Candidate to Prevent the Diabetes-Associated Gastrointestinal Symptoms. Biomolecules, 12(2), https://doi.org/10.3390/biom12020184

Among the histamine receptors, growing evidence points to the histamine H3 receptor as a pharmacological candidate to counteract the autonomic neuropathy associated with diabetes. The study aimed to evaluate the effect of PF00868087 (also known as ZP... Read More about CNS-Sparing Histamine H3 Receptor Antagonist as a Candidate to Prevent the Diabetes-Associated Gastrointestinal Symptoms.

Convergent cross-species pro-cognitive effects of RGH-235, a new potent and selective histamine H3 receptor antagonist/inverse agonist (2022)
Journal Article
Némethy, Z., Kiss, B., Lethbridge, N., Chazot, P., Hajnik, T., Tóth, A., …Lévay, G. (2022). Convergent cross-species pro-cognitive effects of RGH-235, a new potent and selective histamine H3 receptor antagonist/inverse agonist. European Journal of Pharmacology, 916, https://doi.org/10.1016/j.ejphar.2021.174621

The histamine H3 receptor is a favourable target for the treatment of cognitive deficits. Here we report the in vitro and in vivo profile of RGH-235, a new potent, selective, and orally active H3 receptor antagonist/inverse agonist developed by Gedeo... Read More about Convergent cross-species pro-cognitive effects of RGH-235, a new potent and selective histamine H3 receptor antagonist/inverse agonist.