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The well‐worn route revisited: Striatal and hippocampal system contributions to familiar route navigation (2024)
Journal Article
Buckley, M., McGregor, A., Ihssen, N., Austen, J., Thurlbeck, S., Smith, S. P., Heinecke, A., & Lew, A. R. (2024). The well‐worn route revisited: Striatal and hippocampal system contributions to familiar route navigation. Hippocampus, 34(7), 310-326. https://doi.org/10.1002/hipo.23607

Classic research has shown a division in the neuroanatomical structures that support flexible (e.g., short‐cutting) and habitual (e.g., familiar route following) navigational behavior, with hippocampal–caudate systems associated with the former and p... Read More about The well‐worn route revisited: Striatal and hippocampal system contributions to familiar route navigation.

Restricting social networking site use for one week produces varied effects on mood but does not increase explicit or implicit desires to use SNSs: Findings from an ecological momentary assessment study (2023)
Journal Article
Wadsley, M., & Ihssen, N. (2023). Restricting social networking site use for one week produces varied effects on mood but does not increase explicit or implicit desires to use SNSs: Findings from an ecological momentary assessment study. PLoS ONE, 18(11), Article e0293467. https://doi.org/10.1371/journal.pone.0293467

Recent research on the addictive potential of modern technologies such as the internet, smartphones, or social networking sites (SNSs) has suggested that emotional and motivational changes associated with the sudden discontinuation of engagement with... Read More about Restricting social networking site use for one week produces varied effects on mood but does not increase explicit or implicit desires to use SNSs: Findings from an ecological momentary assessment study.

The role of outgroup homogeneity and the neurodynamics of the frontal cortex during beauty comparisons (2023)
Journal Article
Zacharopoulos, G., Ohmann, K., Ihssen, N., Kedia, G., Mussweiler, T., & Linden, D. E. (2023). The role of outgroup homogeneity and the neurodynamics of the frontal cortex during beauty comparisons. Social Neuroscience, 18(6), 382-392. https://doi.org/10.1080/17470919.2023.2242098

The distance effect states that the closer two compared magnitudes (e.g., two numbers, physical attractiveness in two faces), the more difficult the comparison, and the greater the activity of the frontoparietal control network. However, it is unclea... Read More about The role of outgroup homogeneity and the neurodynamics of the frontal cortex during beauty comparisons.

A Systematic Review of Structural and Functional MRI Studies Investigating Social Networking Site Use (2023)
Journal Article
Wadsley, M., & Ihssen, N. (2023). A Systematic Review of Structural and Functional MRI Studies Investigating Social Networking Site Use. Brain Sciences, 13(5), Article 787. https://doi.org/10.3390/brainsci13050787

An understanding of the neurocognitive profile underlying the use of social networking sites (SNSs) can help inform decisions about the classification of problematic SNS use as an addictive disorder and elucidate how/when ‘SNS addiction’ might develo... Read More about A Systematic Review of Structural and Functional MRI Studies Investigating Social Networking Site Use.

The roles of implicit approach motivation and explicit reward in excessive and problematic use of social networking sites (2022)
Journal Article
Wadsley, M., & Ihssen, N. (2022). The roles of implicit approach motivation and explicit reward in excessive and problematic use of social networking sites. PLoS ONE, 17(3), Article e0264738. https://doi.org/10.1371/journal.pone.0264738

Despite growing concerns about the addictive potential of social networking sites (SNSs), little is known about the precise neural, cognitive, and emotional processes underpinning compulsive SNS behaviours, such as excessive checking of SNSs. Recent... Read More about The roles of implicit approach motivation and explicit reward in excessive and problematic use of social networking sites.

Neural coding of human values is underpinned by brain areas representing the core self in the cortical midline region (2021)
Journal Article
Leszkowicz, E., Maio, G. R., Linden, D. E., & Ihssen, N. (2021). Neural coding of human values is underpinned by brain areas representing the core self in the cortical midline region. Social Neuroscience, 16(5), 486-499. https://doi.org/10.1080/17470919.2021.1953582

The impact of human values on our choices depends on their nature. Self-Transcendence values motivate us to act for the benefit of others and care for the environment. Self-Enhancement values motivate us to act for our benefit. The present study exam... Read More about Neural coding of human values is underpinned by brain areas representing the core self in the cortical midline region.

The effects of spatial stability and cue type on spatial learning: Implications for theories of parallel memory systems (2021)
Journal Article
Buckley, M. G., Austen, J. M., Myles, L. A., Smith, S., Ihssen, N., Lew, A. R., & McGregor, A. (2021). The effects of spatial stability and cue type on spatial learning: Implications for theories of parallel memory systems. Cognition, 214, Article 104802. https://doi.org/10.1016/j.cognition.2021.104802

Some theories of spatial learning predict that associative rules apply under only limited circumstances. For example, learning based on a boundary has been claimed to be immune to cue competition effects because boundary information is the basis for... Read More about The effects of spatial stability and cue type on spatial learning: Implications for theories of parallel memory systems.

The Predictive Utility of Reward-Based Motives Underlying Excessive and Problematic Social Networking Site Use (2021)
Journal Article
Wadsley, M., Covey, J., & Ihssen, N. (2022). The Predictive Utility of Reward-Based Motives Underlying Excessive and Problematic Social Networking Site Use. Psychological Reports, 125(5), 2485-2516. https://doi.org/10.1177/00332941211025271

Compulsive seeking of reward is a hallmark feature of drug addiction, but the role of reward is less well understood in behavioural addictions. The present study investigated the predictive utility of ten reward-based motives, which we identified in... Read More about The Predictive Utility of Reward-Based Motives Underlying Excessive and Problematic Social Networking Site Use.

Neurofeedback Training versus Treatment-as-Usual for Alcohol Dependence: Results of an Early-Phase Randomized Controlled Trial and Neuroimaging Correlates (2021)
Journal Article
Subramanian, L., Skottnik, L., Cox, W. M., Luhrs, M., McNamara, R., Hood, K., Watson, G., Whittaker, J. R., Williams, A. N., Sakhuja, R., Ihssen, N., Goebel, R., Playle, R., & Linden, D. E. (2021). Neurofeedback Training versus Treatment-as-Usual for Alcohol Dependence: Results of an Early-Phase Randomized Controlled Trial and Neuroimaging Correlates. European Addiction Research, 27(5), 381-394. https://doi.org/10.1159/000513448

Introduction: Alcohol dependence is one of the most common substance use disorders, and novel treatment options are urgently needed. Neurofeedback training (NFT) based on real-time functional magnetic resonance imaging (rtf­MRI) has emerged as an att... Read More about Neurofeedback Training versus Treatment-as-Usual for Alcohol Dependence: Results of an Early-Phase Randomized Controlled Trial and Neuroimaging Correlates.

A Reward and Incentive-Sensitization Perspective on Compulsive Use of Social Networking Sites - Wanting but not Liking Predicts Checking Frequency and Problematic Use Behavior (2020)
Journal Article
Ihssen, N., & Wadsley, M. (2021). A Reward and Incentive-Sensitization Perspective on Compulsive Use of Social Networking Sites - Wanting but not Liking Predicts Checking Frequency and Problematic Use Behavior. Addictive Behaviors, 116, Article 106808. https://doi.org/10.1016/j.addbeh.2020.106808

The use of Social Networking Sites (SNSs) has exponentially increased over the past decade, leading to warnings about the addictive potential of this technology. Yet, the idea of SNS addiction remains controversial and more theory-driven research is... Read More about A Reward and Incentive-Sensitization Perspective on Compulsive Use of Social Networking Sites - Wanting but not Liking Predicts Checking Frequency and Problematic Use Behavior.

Genetic Variation in the Psychiatric Risk Gene CACNA1C Modulates Reversal Learning Across Species (2018)
Journal Article
Sykes, L., Haddon, J., Lancaster, T. M., Sykes, A., Azzouni, K., Ihssen, N., Moon, A. L., Lin, T.-C. E., Linden, D. E., Owen, M. J., O'Donovan, M. C., Humby, T., Wilkinson, L. S., Thomas, K. L., & Hall, J. (2019). Genetic Variation in the Psychiatric Risk Gene CACNA1C Modulates Reversal Learning Across Species. Schizophrenia Bulletin: The Journal of Psychoses and Related Disorders, 45(5), 1024-1032. https://doi.org/10.1093/schbul/sby146

Genetic variation in CACNA1C, which encodes the alpha-1 subunit of Cav1.2 L-type voltage-gated calcium channels (VGCCs), has been strongly linked to risk for psychiatric disorders including schizophrenia and bipolar disorder. How genetic variation in... Read More about Genetic Variation in the Psychiatric Risk Gene CACNA1C Modulates Reversal Learning Across Species.

Structural and Functional Neuroimaging of Polygenic Risk for Schizophrenia: A Recall-by-Genotype–Based Approach (2018)
Journal Article
Lancaster, T. M., Dimitriadis, S. L., Tansey, K. E., Perry, G., Ihssen, N., Jones, D. K., …Linden, D. E. (2019). Structural and Functional Neuroimaging of Polygenic Risk for Schizophrenia: A Recall-by-Genotype–Based Approach. Schizophrenia Bulletin: The Journal of Psychoses and Related Disorders, 45(2), 405-414. https://doi.org/10.1093/schbul/sby037

Risk profile scores (RPS) derived from genome-wide association studies (GWAS) explain a considerable amount of susceptibility for schizophrenia (SCZ). However, little is known about how common genetic risk factors for SCZ influence the structure and... Read More about Structural and Functional Neuroimaging of Polygenic Risk for Schizophrenia: A Recall-by-Genotype–Based Approach.

Preliminary evidence for genetic overlap between body mass index and striatal reward response (2018)
Journal Article
Lancaster, T. M., Ihssen, N., Brindley, L. M., & Linden, D. E. (2018). Preliminary evidence for genetic overlap between body mass index and striatal reward response. Translational Psychiatry, 8, Article 19. https://doi.org/10.1038/s41398-017-0068-4

The reward-processing network is implicated in the aetiology of obesity. Several lines of evidence suggest obesity-linked genetic risk loci (such as DRD2 and FTO) may influence individual variation in body mass index (BMI) through neuropsychological... Read More about Preliminary evidence for genetic overlap between body mass index and striatal reward response.

So pretty! The neural correlates of self-other vs familiar-other attractiveness comparisons (2017)
Journal Article
Kedia, G., Mussweiler, T., Adam, R., Ischebeck, A., Ihssen, N., & Linden, D. E. (2019). So pretty! The neural correlates of self-other vs familiar-other attractiveness comparisons. Social Neuroscience, 14(1), 41-52. https://doi.org/10.1080/17470919.2017.1397544

Previous research has demonstrated that comparing two persons activates a frontoparietal network associated with numbers and nonsocial magnitudes. However, it is unclear whether this network is also recruited by comparisons involving the self. Self-r... Read More about So pretty! The neural correlates of self-other vs familiar-other attractiveness comparisons.

Evidence of absence: no relationship between behaviourally measured prediction error response and schizotypy (2017)
Journal Article
Humpston, C. S., Evans, L. H., Teufel, C., Ihssen, N., & Linden, D. E. (2017). Evidence of absence: no relationship between behaviourally measured prediction error response and schizotypy. Cognitive Neuropsychiatry, 22(5), 373-390. https://doi.org/10.1080/13546805.2017.1348289

Introduction: The predictive processing framework has attracted much interest in the field of schizophrenia research in recent years, with an increasing number of studies also carried out in healthy individuals with nonclinical psychosis-like experie... Read More about Evidence of absence: no relationship between behaviourally measured prediction error response and schizotypy.

Further support for association between GWAS variant for positive emotion and reward systems (2017)
Journal Article
Lancaster, T., Ihssen, N., Brindley, L., & Linden, D. (2017). Further support for association between GWAS variant for positive emotion and reward systems. Translational Psychiatry, 7, Article e1018. https://doi.org/10.1038/tp.2016.289

A recent genome-wide association study (GWAS) identified a significant single-nucleotide polymorphism (SNP) for trait-positive emotion at rs322931 on chromosome 1, which was also associated with brain activation in the reward system of healthy indivi... Read More about Further support for association between GWAS variant for positive emotion and reward systems.

Neurofeedback training for alcohol dependence versus treatment as usual: study protocol for a randomized controlled trial (2016)
Journal Article
Cox, W., Subramanian, L., Linden, D., Luehrs, M., McNamara, R., Playle, R., …Ihssen, N. (2016). Neurofeedback training for alcohol dependence versus treatment as usual: study protocol for a randomized controlled trial. Trials, 17(1), Article 480. https://doi.org/10.1186/s13063-016-1607-7

Background Real-time functional magnetic resonance imaging (rtfMRI) is used for neurofeedback training (NFT). Preliminary results suggest that it can help patients to control their symptoms. This study uses rtfMRI NFT for relapse prevention in alcoho... Read More about Neurofeedback training for alcohol dependence versus treatment as usual: study protocol for a randomized controlled trial.

Nonlinear associations between human values and neuroanatomy (2016)
Journal Article
Zacharopoulus, G., Hanel, P., Lancaster, T., Ihssen, N., Drakesmith, M., Foley, S., …Linden, D. (2017). Nonlinear associations between human values and neuroanatomy. Social Neuroscience, 12(6), 673-684. https://doi.org/10.1080/17470919.2016.1229215

Human values guide behavior and the smooth functioning of societies. Schwartz’s circumplex model of values predicts a sinusoidal waveform in relations between ratings of the importance of diverse human value types (e.g., achievement, benevolence) and... Read More about Nonlinear associations between human values and neuroanatomy.

A Hedonism Hub in the Human Brain (2016)
Journal Article
Zacharopoulos, G., Lancaster, T., Bracht, T., Ihssen, N., Maio, G., & Linden, D. (2016). A Hedonism Hub in the Human Brain. Cerebral Cortex, 26(10), 3921-3927. https://doi.org/10.1093/cercor/bhw197

Human values are abstract ideals that motivate behavior. The motivational nature of human values raises the possibility that they might be underpinned by brain structures that are particularly involved in motivated behavior and reward processing. We... Read More about A Hedonism Hub in the Human Brain.

Neurofeedback of visual food cue reactivity: a potential avenue to alter incentive sensitization and craving (2016)
Journal Article
Ihssen, N., Sokunbi, M., Lawrence, A., Lawrence, N., & Linden, D. (2016). Neurofeedback of visual food cue reactivity: a potential avenue to alter incentive sensitization and craving. Brain Imaging and Behavior, 11(3), 915-924. https://doi.org/10.1007/s11682-016-9558-x

FMRI-based neurofeedback transforms functional brain activation in real-time into sensory stimuli that participants can use to self-regulate brain responses, which can aid the modification of mental states and behavior. Emerging evidence supports the... Read More about Neurofeedback of visual food cue reactivity: a potential avenue to alter incentive sensitization and craving.