All Outputs (5)

The C-glycosylation of flavonoids in cereals (2009)
Journal Article
Brazier-Hicks, M., Evans, K., Gershater, M., Puschmann, H., Steel, P., & Edwards, R. (2009). The C-glycosylation of flavonoids in cereals. Journal of Biological Chemistry, 284(27), 17926-17934. https://doi.org/10.1074/jbc.m109.009258

Flavonoids normally accumulate in plants as O-glycosylated derivatives, but several species, including major cereal crops, predominantly synthesize flavone-C-glycosides, which are stable to hydrolysis and are biologically active both in planta and as... Read More about The C-glycosylation of flavonoids in cereals.

A kinetic model for the metabolism of the herbicide safener fenclorim in Arabidopsis thaliana. (2009)
Journal Article
Liu, J., Brazier-Hicks, M., & Edwards, R. (2009). A kinetic model for the metabolism of the herbicide safener fenclorim in Arabidopsis thaliana. Biophysical Chemistry, 143(1-2), 85-94. https://doi.org/10.1016/j.bpc.2009.04.006

Glutathione transferases (GSTs) catalyse the detoxification of a range of xenobiotics, including crop protection agents in plants. Recent studies in cultures of the model plant Arabidopsis thaliana have shown that the herbicide safener fenclorim (4,6... Read More about A kinetic model for the metabolism of the herbicide safener fenclorim in Arabidopsis thaliana..

Catabolism of glutathione conjugates in Arabidopsis thaliana: role in metabolic reactivation of the herbicide safener fenclorim. (2008)
Journal Article
Brazier-Hicks, M., Evans, K., Cunningham, O., Hodgson, D., Steel, P., & Edwards, R. (2008). Catabolism of glutathione conjugates in Arabidopsis thaliana: role in metabolic reactivation of the herbicide safener fenclorim. Journal of Biological Chemistry, 283(30), 21102-21112. https://doi.org/10.1074/jbc.m801998200

The safener fenclorim (4,6-dichloro-2-phenylpyrimidine) increases tolerance to chloroacetanilide herbicides in rice by enhancing the expression of detoxifying glutathione S-transferases (GSTs). Fenclorim also enhances GSTs in Arabidopsis thaliana, an... Read More about Catabolism of glutathione conjugates in Arabidopsis thaliana: role in metabolic reactivation of the herbicide safener fenclorim..

Selection of plants for roles in phytoremediation: the importance of glucosylation (2007)
Journal Article
Brazier-Hicks, M., Edwards, L., & Edwards, R. (2007). Selection of plants for roles in phytoremediation: the importance of glucosylation. Plant Biotechnology Journal, 5(5), 627-635. https://doi.org/10.1111/j.1467-7652.2007.00266.x

Over-expression and transposon mutagenesis in root cultures of Arabidopsis thaliana demonstrated the importance of the family 1 glycosyltransferase UGT72B1 in catalysing the N-glucosylation of the persistent pollutant 3,4-dichloroaniline (DCA). In ph... Read More about Selection of plants for roles in phytoremediation: the importance of glucosylation.

Functional importance of the family 1 glucosyltransferase UGT72B1 in the metabolism of xenobiotics in Arabidopsis thaliana (2005)
Journal Article
Brazier-Hicks, M., & Edwards, R. (2005). Functional importance of the family 1 glucosyltransferase UGT72B1 in the metabolism of xenobiotics in Arabidopsis thaliana. The Plant Journal, 42(4), 556-566. https://doi.org/10.1111/j.1365-313x.2005.02398.x

The Arabidopsis type 1 UDP-glucose-dependent glucosyltransferase UGT72B1 is highly active in conjugating the persistent pollutants 3,4-dichloroaniline (DCA) and 2,4,5-trichlorophenol (TCP). To determine its importance in detoxifying xenobiotics in pl... Read More about Functional importance of the family 1 glucosyltransferase UGT72B1 in the metabolism of xenobiotics in Arabidopsis thaliana.