Skip to main content

Research Repository

Advanced Search

All Outputs (7)

Investigation into the significant role of dermal‐epidermal interactions in skin ageing utilising a bioengineered skin construct (2024)
Journal Article
Costello, L., Goncalves, K., De Los Santos Gomez, P., Hulette, B., Dicolandrea, T., Flagler, M. J., Isfort, R., Oblong, J., Bascom, C., & Przyborski, S. (online). Investigation into the significant role of dermal‐epidermal interactions in skin ageing utilising a bioengineered skin construct. Journal of Cellular Physiology, https://doi.org/10.1002/jcp.31463

Increased prevalence of skin ageing is a growing concern due to an ageing global population and has both sociological and psychological implications. The use of more clinically predictive in vitro methods for dermatological research is becoming comm... Read More about Investigation into the significant role of dermal‐epidermal interactions in skin ageing utilising a bioengineered skin construct.

Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule. (2024)
Journal Article
Kelly, G., Kataura, T., Panek, J., Ma, G., Salmonowicz, H., Davis, A., Kendall, H., Brookes, C., Ayine-Tora, D. M., Banks, P., Nelson, G., Dobby, L., Pitrez, P. R., Booth, L., Costello, L., Richardson, G. D., Lovat, P., Przyborski, S., Ferreira, L., Greaves, L., …Korolchuk, V. I. (2024). Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule. Developmental Cell, 59(15), 1924-1939. https://doi.org/10.1016/j.devcel.2024.04.020

Selective degradation of damaged mitochondria by autophagy (mitophagy) is proposed to play an important role in cellular homeostasis. However, the molecular mechanisms and the requirement of mitochondrial quality control by mitophagy for cellular phy... Read More about Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule..

Comparison of photodamage in non-pigmented and pigmented human skin equivalents exposed to repeated ultraviolet radiation to investigate the role of melanocytes in skin photoprotection (2024)
Journal Article
De Los Santos Gomez, P., Costello, L., Goncalves, K., & Przyborski, S. (2024). Comparison of photodamage in non-pigmented and pigmented human skin equivalents exposed to repeated ultraviolet radiation to investigate the role of melanocytes in skin photoprotection. Frontiers in Medicine, 11, Article 1355799. https://doi.org/10.3389/fmed.2024.1355799

Introduction: Daily solar ultraviolet (UV) radiation has an important impact on skin health. Understanding the initial events of the UV-induced response is critical to prevent deleterious conditions. However, studies in human volunteers have ethical,... Read More about Comparison of photodamage in non-pigmented and pigmented human skin equivalents exposed to repeated ultraviolet radiation to investigate the role of melanocytes in skin photoprotection.

Cell Senescence-Independent Changes of Human Skin Fibroblasts with Age (2024)
Journal Article
Fullard, N., Wordsworth, J., Welsh, C., Maltman, V., Bascom, C., Tasseff, R., …Shanley, D. (2024). Cell Senescence-Independent Changes of Human Skin Fibroblasts with Age. Cells, 13(8), Article 659. https://doi.org/10.3390/cells13080659

Skin ageing is defined, in part, by collagen depletion and fragmentation that leads to a loss of mechanical tension. This is currently believed to reflect, in part, the accumulation of senescent cells. We compared the expression of genes and proteins... Read More about Cell Senescence-Independent Changes of Human Skin Fibroblasts with Age.

Development of a novel in vitro strategy to understand the impact of shaving on skin health: combining tape strip exfoliation and human skin equivalent technology (2023)
Journal Article
Costello, L., Goncalves, K., Maltman, V., Barrett, N., Shah, K., Stephens, A., …Przyborski, S. (2023). Development of a novel in vitro strategy to understand the impact of shaving on skin health: combining tape strip exfoliation and human skin equivalent technology. Frontiers in Medicine, 10, Article 1236790. https://doi.org/10.3389/fmed.2023.1236790

Introduction: The removal of unwanted hair is a widespread grooming practice adopted by both males and females. Although many depilatory techniques are now available, shaving remains the most common, despite its propensity to irritate skin. Current t... Read More about Development of a novel in vitro strategy to understand the impact of shaving on skin health: combining tape strip exfoliation and human skin equivalent technology.

Engineering a Multilayered Skin Equivalent: The Importance of Endogenous Extracellular Matrix Maturation to Provide Robustness and Reproducibility (2019)
Book Chapter
Costello, L., Fullard, N., Roger, M., Bradbury, S., Dicolandrea, T., Isfort, R., …Przyborski, S. (2019). Engineering a Multilayered Skin Equivalent: The Importance of Endogenous Extracellular Matrix Maturation to Provide Robustness and Reproducibility. In S. Böttcher-Haberzeth, & T. Biedermann (Eds.), Skin Tissue Engineering (107-122). https://doi.org/10.1007/978-1-4939-9473-1_9

Bioengineering the Microanatomy of Human Skin (2019)
Journal Article
Roger, M., Fullard, N., Costello, L., Bradbury, S., Markiewicz, E., O'Reilly, S., …Przyborski, S. (2019). Bioengineering the Microanatomy of Human Skin. Journal of Anatomy, 234(4), 438-455. https://doi.org/10.1111/joa.12942

Recreating the structure of human tissues in the laboratory is valuable for fundamental research, testing interventions, and reducing the use of animals. Critical to the use of such technology is the ability to produce tissue models that accurately r... Read More about Bioengineering the Microanatomy of Human Skin.