All Outputs (15)

Insoluble Aβ overexpression in an App knock-in mouse model alters microstructure and gamma oscillations in the prefrontal cortex, and impacts on anxiety-related behaviours (2019)
Journal Article
Pervolaraki, E., Hall, S., Foresteire, D., Saito, T., Saido, T., Whittington, M., …Dachtler, J. (2019). Insoluble Aβ overexpression in an App knock-in mouse model alters microstructure and gamma oscillations in the prefrontal cortex, and impacts on anxiety-related behaviours. Disease Models and Mechanisms, 12(9), Article dmm040550. https://doi.org/10.1242/dmm.040550

We studied a new App knock-in mice model of Alzheimer’s disease (AppNL-G-F), containing the Swedish KM670/671NL mutation, the Iberian I716F mutation and the Artic E693G mutation, which generates elevated levels of Aβ40 and Aβ42 without the confounds... Read More about Insoluble Aβ overexpression in an App knock-in mouse model alters microstructure and gamma oscillations in the prefrontal cortex, and impacts on anxiety-related behaviours.

En route to delineating hippocampal roles in spatial learning (2019)
Journal Article
Poulter, S., Austen, J. M., Kosaki, Y., Dachtler, J., Lever, C., & McGregor, A. (2019). En route to delineating hippocampal roles in spatial learning. Behavioural Brain Research, 369, Article 111936. https://doi.org/10.1016/j.bbr.2019.111936

The precise role played by the hippocampus in spatial learning tasks, such as the Morris Water Maze (MWM), is not fully understood. One theory is that the hippocampus is not required for ‘knowing where’ but rather is crucial in ‘getting there’. To ex... Read More about En route to delineating hippocampal roles in spatial learning.

The within-subject application of diffusion tensor MRI and CLARITY reveals brain structural changes in Nrxn2 deletion mice (2019)
Journal Article
Pervolaraki, E., Tyson, A., Pibiri, F., Poulter, S., Reichelt, A., Rodgers, R., …Dachtler, J. (2019). The within-subject application of diffusion tensor MRI and CLARITY reveals brain structural changes in Nrxn2 deletion mice. Molecular Autism, 10, Article 8. https://doi.org/10.1186/s13229-019-0261-9

Background: Of the many genetic mutations known to increase the risk of autism spectrum disorder, a large proportion cluster upon synaptic proteins. One such family of presynaptic proteins are the neurexins (NRXN), and recent genetic and mouse eviden... Read More about The within-subject application of diffusion tensor MRI and CLARITY reveals brain structural changes in Nrxn2 deletion mice.

An intermittent hypercaloric diet alters gut microbiota, prefrontal cortical gene expression and social behaviours in rats (2018)
Journal Article
Reichelt, A., Loughman, A., Bernard, A., Raipuria, M., Abbott, K., Dachtler, J., …Moore, R. (2020). An intermittent hypercaloric diet alters gut microbiota, prefrontal cortical gene expression and social behaviours in rats. Nutritional Neuroscience, 23(8), 613-627. https://doi.org/10.1080/1028415x.2018.1537169

Objectives: Excessive consumption of high fat and high sugar (HFHS) diets alters reward processing, behaviour, and changes gut microbiota profiles. Previous studies in gnotobiotic mice also provide evidence that these gut microorganisms may influence... Read More about An intermittent hypercaloric diet alters gut microbiota, prefrontal cortical gene expression and social behaviours in rats.

The developmental transcriptome of the human heart (2018)
Journal Article
Pervolaraki, E., Dachtler, J., Anderson, R., & Holden, A. (2018). The developmental transcriptome of the human heart. Scientific Reports, 8(1), Article 15362. https://doi.org/10.1038/s41598-018-33837-6

The human heart develops through complex mechanisms producing morphological and functional changes during gestation. We have recently demonstrated using diffusion tensor MRI that over the relatively short space of 40 days, between 100–140 days gestat... Read More about The developmental transcriptome of the human heart.

Ventricular myocardium development and the role of connexins in the human fetal heart (2017)
Journal Article
Pervolaraki, E., Dachtler, J., Anderson, R., & Holden, A. (2017). Ventricular myocardium development and the role of connexins in the human fetal heart. Scientific Reports, 7(1), Article 12272. https://doi.org/10.1038/s41598-017-11129-9

The developmental timeline of the human heart remains elusive. The heart takes on its characteristic four chambered appearance by ~56 days gestational age (DGA). However, owing to the complexities (both technical and logistical) of exploring developm... Read More about Ventricular myocardium development and the role of connexins in the human fetal heart.

Do cortical plasticity mechanisms differ between males and females? (2016)
Journal Article
Dachtler, J., & Fox, K. (2017). Do cortical plasticity mechanisms differ between males and females?. Journal of Neuroscience Research, 95(1-2), 518-526. https://doi.org/10.1002/jnr.23850

The difference between male and female behavior and male and female susceptibility to a number of neuropsychiatric conditions is not controversial. From a biological perspective, one might expect to see at least some of these differences underpinned... Read More about Do cortical plasticity mechanisms differ between males and females?.

Missense mutation in DISC1 C-terminal coiled-coil has GSK3β signaling and sex-dependent behavioral effects in mice (2016)
Journal Article
Dachtler, J., Elliott, C., Rodgers, R., Baillie, G., & Clapcote, S. (2016). Missense mutation in DISC1 C-terminal coiled-coil has GSK3β signaling and sex-dependent behavioral effects in mice. Scientific Reports, 6, https://doi.org/10.1038/srep18748

Disrupted-in-Schizophrenia 1 (DISC1) is a risk factor for schizophrenia and affective disorders. The full-length DISC1 protein consists of an N-terminal ‘head’ domain and a C-terminal tail domain that contains several predicted coiled-coils, structur... Read More about Missense mutation in DISC1 C-terminal coiled-coil has GSK3β signaling and sex-dependent behavioral effects in mice.

Heterozygous deletion of α-neurexin I or α-neurexin II results in behaviors relevant to autism and schizophrenia (2015)
Journal Article
Dachtler, J., Ivorra, J., Rowland, T., Lever, C., Rodgers, R., & Clapcote, S. (2015). Heterozygous deletion of α-neurexin I or α-neurexin II results in behaviors relevant to autism and schizophrenia. Behavioral Neuroscience, 129(6), 765-776. https://doi.org/10.1037/bne0000108

The neurexins are a family of presynaptic cell adhesion molecules. Human genetic studies have found heterozygous deletions affecting NRXN1 and NRXN2, encoding α-neurexin I (Nrxn1α) and α-neurexin II (Nrxn2α), in individuals with autism spectrum disor... Read More about Heterozygous deletion of α-neurexin I or α-neurexin II results in behaviors relevant to autism and schizophrenia.

Characterization of cognitive deficits in mice with an alternating hemiplegia-linked mutation (2015)
Journal Article
Kirshenbaum, G., Dachtler, J., Roder, J., & Clapcote, S. (2015). Characterization of cognitive deficits in mice with an alternating hemiplegia-linked mutation. Behavioral Neuroscience, 129(6), 822-831. https://doi.org/10.1037/bne0000097

Cognitive impairment is a prominent feature in a range of different movement disorders. Children with Alternating Hemiplegia of Childhood are prone to developmental delay, with deficits in cognitive functioning becoming progressively more evident as... Read More about Characterization of cognitive deficits in mice with an alternating hemiplegia-linked mutation.

Transgenic rescue of phenotypic deficits in a mouse model of alternating hemiplegia of childhood (2015)
Journal Article
Kirshenbaum, G., Dachtler, J., Roder, J., & Clapcote, S. (2016). Transgenic rescue of phenotypic deficits in a mouse model of alternating hemiplegia of childhood. neurogenetics, 17(1), 57-63. https://doi.org/10.1007/s10048-015-0461-1

Missense mutations in ATP1A3 encoding Na+,K+-ATPase α3 are the primary cause of alternating hemiplegia of childhood (AHC). Most ATP1A3 mutations in AHC lie within a cluster in or near transmembrane α-helix TM6, including I810N that is also found in t... Read More about Transgenic rescue of phenotypic deficits in a mouse model of alternating hemiplegia of childhood.

Deletion of α-neurexin II results in autism-related behaviors in mice (2014)
Journal Article
Dachtler, J., Glasper, J., Cohen, R., Ivorra, J., Swiffen, D., Jackson, A., …Clapcote, S. (2014). Deletion of α-neurexin II results in autism-related behaviors in mice. Translational Psychiatry, 4(11), Article e484. https://doi.org/10.1038/tp.2014.123

Autism is a common and frequently disabling neurodevelopmental disorder with a strong genetic basis. Human genetic studies have discovered mutations disrupting exons of the NRXN2 gene, which encodes the synaptic adhesion protein α-neurexin II (Nrxn2α... Read More about Deletion of α-neurexin II results in autism-related behaviors in mice.

The role of nitric oxide in pre-synaptic plasticity and homeostasis (2013)
Journal Article
Hardingham, N., Dachtler, J., & Fox, K. (2013). The role of nitric oxide in pre-synaptic plasticity and homeostasis. Frontiers in Cellular Neuroscience, 7, Article 190. https://doi.org/10.3389/fncel.2013.00190

Since the observation that nitric oxide (NO) can act as an intercellular messenger in the brain, the past 25 years have witnessed the steady accumulation of evidence that it acts pre-synaptically at both glutamatergic and GABAergic synapses to alter... Read More about The role of nitric oxide in pre-synaptic plasticity and homeostasis.

The role of nitric oxide synthase in cortical plasticity is sex specific (2012)
Journal Article
Dachtler, J., Hardingham, N., & Fox, K. (2012). The role of nitric oxide synthase in cortical plasticity is sex specific. Journal of Neuroscience, 32(43), 14994-14999. https://doi.org/10.1523/jneurosci.3189-12.2012

Nitric oxide synthase-1 (NOS1) is involved in several forms of plasticity including hippocampal-dependent learning and memory, experience-dependent plasticity in the barrel cortex, and long-term potentiation (LTP) in the hippocampus and neocortex. NO... Read More about The role of nitric oxide synthase in cortical plasticity is sex specific.

Experience-dependent plasticity acts via GluR1 and a novel neuronal nitric oxide synthase-dependent synaptic mechanism in adult cortex (2011)
Journal Article
Dachtler, J., Hardingham, N., Glazewski, S., Wright, N., Blain, E., & Fox, K. (2011). Experience-dependent plasticity acts via GluR1 and a novel neuronal nitric oxide synthase-dependent synaptic mechanism in adult cortex. Journal of Neuroscience, 31(31), 11220-11230. https://doi.org/10.1523/jneurosci.1590-11.2011

Synaptic plasticity directs development of the nervous system and is thought to underlie memory storage in adult animals. A great deal of our current understanding of the role of AMPA receptors in synaptic plasticity comes from studies on developing... Read More about Experience-dependent plasticity acts via GluR1 and a novel neuronal nitric oxide synthase-dependent synaptic mechanism in adult cortex.