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All Outputs (4)

Extrinsic lactose fines improve dry powder inhaler formulation performance of a cohesive batch of budesonide via agglomerate formation and consequential co-deposition (2015)
Journal Article
Kinnunen, H., Hebbink, G., Peters, H., Huck, D., Makein, L., & Price, R. (2015). Extrinsic lactose fines improve dry powder inhaler formulation performance of a cohesive batch of budesonide via agglomerate formation and consequential co-deposition. International Journal of Pharmaceutics, 478(1), 53-59. https://doi.org/10.1016/j.ijpharm.2014.11.019

The aim of the study was to investigate how the fine particle content of lactose carriers prepared with different types of lactose fines regulates dry powder inhaler (DPI) formulation performance of a cohesive batch of micronised budesonide. Budesoni... Read More about Extrinsic lactose fines improve dry powder inhaler formulation performance of a cohesive batch of budesonide via agglomerate formation and consequential co-deposition.

Defining the critical material attributes of lactose monohydrate in carrier based dry powder inhaler formulations using artificial neural networks (2014)
Journal Article
Kinnunen, H., Hebbink, G., Peters, H., Shur, J., & Price, R. (2014). Defining the critical material attributes of lactose monohydrate in carrier based dry powder inhaler formulations using artificial neural networks. AAPS PharmSciTech, 15(4), 1009-1020. https://doi.org/10.1208/s12249-014-0108-9

The study aimed to establish a function-based relationship between the physical and bulk properties of pre-blended mixtures of fine and coarse lactose grades with the in vitro performance of an adhesive active pharmaceutical ingredient (API). Differe... Read More about Defining the critical material attributes of lactose monohydrate in carrier based dry powder inhaler formulations using artificial neural networks.

An investigation into the effect of fine lactose particles on the fluidization behaviour and aerosolization performance of carrier-based dry powder inhaler formulations (2014)
Journal Article
Kinnunen, H., Hebbink, G., Peters, H., Shur, J., & Price, R. (2014). An investigation into the effect of fine lactose particles on the fluidization behaviour and aerosolization performance of carrier-based dry powder inhaler formulations. AAPS PharmSciTech, 15(4), 898-909. https://doi.org/10.1208/s12249-014-0119-6

The effect of milled and micronized lactose fines on the fluidization and in vitro aerosolization properties of dry powder inhaler (DPI) formulations was investigated, and the suitability of static and dynamic methods for characterizing general powde... Read More about An investigation into the effect of fine lactose particles on the fluidization behaviour and aerosolization performance of carrier-based dry powder inhaler formulations.

Improving the outcomes of biopharmaceutical delivery via the subcutaneous route by understanding the chemical, physical and physiological properties of the subcutaneous injection site (2014)
Journal Article
Kinnunen, H., & Mrsny, R. (2014). Improving the outcomes of biopharmaceutical delivery via the subcutaneous route by understanding the chemical, physical and physiological properties of the subcutaneous injection site. Journal of Controlled Release, 182, 22-32. https://doi.org/10.1016/j.jconrel.2014.03.011

Subcutaneous (SC) injection is currently the most common route of self-administering biopharmaceuticals such as proteins and peptides. While pharmaceutical scientists have acquired great skill in identifying formulations for these proteins and peptid... Read More about Improving the outcomes of biopharmaceutical delivery via the subcutaneous route by understanding the chemical, physical and physiological properties of the subcutaneous injection site.