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All Outputs (13)

Epithelial Stem Cells: Making, Shaping and Breaking the Niche (2022)
Book Chapter
Ferraces-Riegas, P., Galbraith, A. C., & Doupé, D. P. (2022). Epithelial Stem Cells: Making, Shaping and Breaking the Niche. In Advances in Experimental Medicine and Biology. Springer Verlag. https://doi.org/10.1007/5584_2021_686

Epithelial stem cells maintain tissues throughout adult life and are tightly regulated by their microenvironmental niche to balance cell production and loss. These stem cells have been studied extensively as signal-receiving cells, responding to cues... Read More about Epithelial Stem Cells: Making, Shaping and Breaking the Niche.

Drosophila intestinal stem and progenitor cells are major sources and regulators of homeostatic niche signals (2018)
Journal Article
Doupé, D., Marshall, O., Dayton, H., Brand, A., & Perrimon, N. (2018). Drosophila intestinal stem and progenitor cells are major sources and regulators of homeostatic niche signals. Proceedings of the National Academy of Sciences, 115(48), 12218-12223. https://doi.org/10.1073/pnas.1719169115

Epithelial homeostasis requires the precise balance of epithelial stem/progenitor proliferation and differentiation. While many signaling pathways that regulate epithelial stem cells have been identified, it is probable that other regulators remain u... Read More about Drosophila intestinal stem and progenitor cells are major sources and regulators of homeostatic niche signals.

Quantitative 3D analysis of complex single border cell behaviors in coordinated collective cell migration (2017)
Journal Article
Cliffe, A., Doupé, D. P., Sung, H., Lim, I. K. H., Ong, K. H., Cheng, L., & Yu, W. (2017). Quantitative 3D analysis of complex single border cell behaviors in coordinated collective cell migration. Nature Communications, 8, Article 14905. https://doi.org/10.1038/ncomms14905

Understanding the mechanisms of collective cell migration is crucial for cancer metastasis, wound healing and many developmental processes. Imaging a migrating cluster in vivo is feasible, but the quantification of individual cell behaviours remains... Read More about Quantitative 3D analysis of complex single border cell behaviors in coordinated collective cell migration.

Toward a Systems Understanding of Signaling Pathway Function (2016)
Book Chapter
Doupé, D. P., & Perrimon, N. (2016). Toward a Systems Understanding of Signaling Pathway Function. In P. M. Wassarman (Ed.), Essays on Developmental Biology, Part B (221-236). Elsevier. https://doi.org/10.1016/bs.ctdb.2015.11.005

A small number of developmental signaling pathways are used repeatedly throughout development in many different contexts. How these pathways interact with each other and the specific cell context to generate a wide range of appropriate responses rema... Read More about Toward a Systems Understanding of Signaling Pathway Function.

Visualizing and Manipulating Temporal Signaling Dynamics with Fluorescence-Based Tools (2014)
Journal Article
Doupé, D., & Perrimon, N. (2014). Visualizing and Manipulating Temporal Signaling Dynamics with Fluorescence-Based Tools. Science Signaling, 7(319), https://doi.org/10.1126/scisignal.2005077

The use of genome-wide proteomic and RNA interference approaches has moved our understanding of signal transduction from linear pathways to highly integrated networks centered on core nodes. However, probing the dynamics of flow of information throug... Read More about Visualizing and Manipulating Temporal Signaling Dynamics with Fluorescence-Based Tools.