All Outputs (5)

Developmental ROS individualizes organismal stress resistance and lifespan (2019)
Journal Article
Bazopoulou, D., Knoefler, D., Zheng, Y., Ulrich, K., Oleson, B., Xie, L., …Jakob, U. (2019). Developmental ROS individualizes organismal stress resistance and lifespan. Nature, 576(7786), 301-305. https://doi.org/10.1038/s41586-019-1814-y

A central aspect of aging research concerns the question of when individuality in lifespan arises. Here we show that a transient increase in reactive oxygen species (ROS), which occurs naturally during early development in a subpopulation of synchron... Read More about Developmental ROS individualizes organismal stress resistance and lifespan.

The anti-inflammatory drug mesalamine targets bacterial polyphosphate accumulation (2017)
Journal Article
Dahl, J., Gray, M., Bazopoulou, D., Beaufay, F., Lempart, J., Koenigsknecht, M., …Jakob, U. (2017). The anti-inflammatory drug mesalamine targets bacterial polyphosphate accumulation. Nature Microbiology, 2, Article 16267. https://doi.org/10.1038/nmicrobiol.2016.267

Mesalamine serves as the gold standard in treating ulcerative colitis. However, its precise mechanism(s) of action remains unclear. Here, we show that mesalamine treatment rapidly decreases polyphosphate levels in diverse bacteria, including members... Read More about The anti-inflammatory drug mesalamine targets bacterial polyphosphate accumulation.

Microfluidics for Neuronal Imaging (2014)
Book Chapter
Bazopoulou, D., & Chronis, N. (2014). Microfluidics for Neuronal Imaging. In Neural Computation, Neural Devices, and Neural Prosthesis (243-259). Springer Verlag. https://doi.org/10.1007/978-1-4614-8151-5_10

In neurobiology studies, the use of well-controllable microenvironments that can actively interact with biological samples is becoming increasingly popular. Microfluidic systems due to their precise micron-size dimensions are becoming the gold standa... Read More about Microfluidics for Neuronal Imaging.

Mechanosensitive Ion Channels in Caenorhabditis elegans (2007)
Book Chapter
Bazopoulou, D., & Tavernarakis, N. (2007). Mechanosensitive Ion Channels in Caenorhabditis elegans. In O. P. Hamill (Ed.), Mechanosensitive Ion Channels, Part B (49-79). Academic Press. https://doi.org/10.1016/s1063-5823%2806%2959003-9

Caenorhabditis elegans depends critically on mechanosensory perception to negotiate its natural habitat, the soil. The worm displays a rich repertoire of mechanosensitive behaviors, which can be easily examined in the laboratory. This, coupled with t... Read More about Mechanosensitive Ion Channels in Caenorhabditis elegans.

The role of DEG/ENaC ion channels in sensory mechanotransduction (2007)
Book Chapter
Bazopoulou, D., Voglis, G., & Tavernarakis, N. (2007). The role of DEG/ENaC ion channels in sensory mechanotransduction. In Molecular Sensors for Cardiovascular Homeostasis (3-31). Springer US. https://doi.org/10.1007/978-0-387-47530-1_1

All living organisms have the capacity to sense and respond to mechanical stimuli permeating their environment. Mechanosensory signaling constitutes the basis for the senses of touch and hearing and contributes fundamentally to development and homeos... Read More about The role of DEG/ENaC ion channels in sensory mechanotransduction.