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A Glycopolymer Sensor Array That Differentiates Lectins and Bacteria (2024)
Journal Article
Leslie, K. G., Jolliffe, K. A., Müllner, M., New, E. J., Turnbull, W. B., Fascione, M. A., Friman, V.-P., & Mahon, C. S. (online). A Glycopolymer Sensor Array That Differentiates Lectins and Bacteria. Biomacromolecules, https://doi.org/10.1021/acs.biomac.4c01129

Identification of bacterial lectins offers an attractive route to the development of new diagnostics, but the design of specific sensors is complicated by the low selectivity of carbohydrate-lectin interactions. Here we describe a glycopolymer-based... Read More about A Glycopolymer Sensor Array That Differentiates Lectins and Bacteria.

Sugar-Coated: Can Multivalent Glycoconjugates Improve upon Nature’s Design? (2024)
Journal Article
Leslie, K. G., Berry, S. S., Miller, G. J., & Mahon, C. S. (2024). Sugar-Coated: Can Multivalent Glycoconjugates Improve upon Nature’s Design?. Journal of the American Chemical Society, 146(40), 27215-27232. https://doi.org/10.1021/jacs.4c08818

Multivalent interactions between receptors and glycans play an important role in many different biological processes, including pathogen infection, self-recognition, and the immune response. The growth in the number of tools and techniques toward the... Read More about Sugar-Coated: Can Multivalent Glycoconjugates Improve upon Nature’s Design?.

Adaptable Synthesis of Chondroitin Sulfate Disaccharide Subtypes Preprogrammed for Regiospecific O‐Sulfation (2024)
Journal Article
Wootton, H. S., Berry, S. S., Ferguson, E. L., Mahon, C. S., & Miller, G. J. (2024). Adaptable Synthesis of Chondroitin Sulfate Disaccharide Subtypes Preprogrammed for Regiospecific O‐Sulfation. European Journal of Organic Chemistry, 27(40), Article e202400587. https://doi.org/10.1002/ejoc.202400587

A divergent synthetic route to chondroitin sulfate (CS) disaccharide precursors, including rarer subtypes such as CS-D, has been developed. From common intermediates, a series of thioglycoside D-glucosyl donors and 4,6-O-benzylidene protected D-galac... Read More about Adaptable Synthesis of Chondroitin Sulfate Disaccharide Subtypes Preprogrammed for Regiospecific O‐Sulfation.

Designing biodegradable alternatives to commodity polymers (2023)
Journal Article
Fiandra, E. F., Shaw, L., Starck, M., McGurk, C. J., & Mahon, C. S. (2023). Designing biodegradable alternatives to commodity polymers. Chemical Society Reviews, 23(52), 8085-8105. https://doi.org/10.1039/d3cs00556a

The development and widespread adoption of commodity polymers changed societal landscapes on a global scale. Without the everyday materials used in packaging, textiles, construction and medicine, our lives would be unrecognisable. Through decades of... Read More about Designing biodegradable alternatives to commodity polymers.

Electrochemical and thermal detection of allergenic substance lysozyme with molecularly imprinted nanoparticles (2023)
Journal Article
Singla, P., Kaur, S., Jamieson, O., Dann, A., Garg, S., Mahon, C., …Peeters, M. (2023). Electrochemical and thermal detection of allergenic substance lysozyme with molecularly imprinted nanoparticles. Analytical and Bioanalytical Chemistry, 415(18), 4467-4478. https://doi.org/10.1007/s00216-023-04638-2

Lysozyme (LYZ) is a small cationic protein which is widely used for medical treatment and in the food industry to act as an anti-bacterial agent; however, it can trigger allergic reactions. In this study, high-affinity molecularly imprinted nanoparti... Read More about Electrochemical and thermal detection of allergenic substance lysozyme with molecularly imprinted nanoparticles.

A Tale of Two Bioconjugations: pH Controlled Divergent Reactivity of Protein α-oxo-Aldehydes in Competing α-oxo-Mannich and Catalyst-Free Aldol Ligations (2021)
Journal Article
Keenan, T., Spears, R. J., Akkad, S., Mahon, C. S., Hatton, N. E., Walton, J., Noble, A., Yates, N. D., Baumann, C. G., Parkin, A., Signoret, N., & Fascione, M. A. (2021). A Tale of Two Bioconjugations: pH Controlled Divergent Reactivity of Protein α-oxo-Aldehydes in Competing α-oxo-Mannich and Catalyst-Free Aldol Ligations. ACS Chemical Biology, 16(11), 2387-2400. https://doi.org/10.1021/acschembio.1c00531

Site-selective chemical methods for protein bioconjugation have revolutionized the fields of cell and chemical biology through the development of novel protein/enzyme probes bearing fluorescent, spectroscopic, or even toxic cargos. Herein, we report... Read More about A Tale of Two Bioconjugations: pH Controlled Divergent Reactivity of Protein α-oxo-Aldehydes in Competing α-oxo-Mannich and Catalyst-Free Aldol Ligations.

Glycomacromolecules: Addressing challenges in drug delivery and therapeutic development (2021)
Journal Article
Stuart-Walker, W., & Mahon, C. S. (2021). Glycomacromolecules: Addressing challenges in drug delivery and therapeutic development. Advanced Drug Delivery Reviews, 171, 77-93. https://doi.org/10.1016/j.addr.2021.01.018

Carbohydrate-based materials offer exciting opportunities for drug delivery. They present readily available, biocompatible components for the construction of macromolecular systems which can be loaded with cargo, and can enable targeting of a payload... Read More about Glycomacromolecules: Addressing challenges in drug delivery and therapeutic development.

Macromolecular Optical Sensor Arrays (2021)
Journal Article
Mitchell, L., New, E. J., & Mahon, C. S. (2021). Macromolecular Optical Sensor Arrays. ACS Applied Polymer Materials, 3(2), 506-530. https://doi.org/10.1021/acsapm.0c01003

Chemical sensors play an important role in our understanding of chemical and biological systems, providing sensitive and rapid detection of a variety of substrates. Array-based sensing approaches avoid the ongoing challenge of designing and synthesiz... Read More about Macromolecular Optical Sensor Arrays.

A Regenerable Biosensing Platform for Bacterial Toxins (2020)
Journal Article
Antunez, E. E., Mahon, C. S., Tong, Z., Voelcker, N. H., & Müllner, M. (2021). A Regenerable Biosensing Platform for Bacterial Toxins. Biomacromolecules, 22(2), 441-453. https://doi.org/10.1021/acs.biomac.0c01318

Waterborne diarrheal diseases such as travelers’ diarrhea and cholera remain a threat to public health in many countries. Rapid diagnosis of an infectious disease is critical in preventing the escalation of a disease outbreak into an epidemic. Many o... Read More about A Regenerable Biosensing Platform for Bacterial Toxins.

Cylindrical Zwitterionic Particles via Interpolyelectrolyte Complexation on Molecular Polymer Brushes (2020)
Journal Article
Pelras, T., Nonappa, Mahon, C. S., & Müllner, M. (2021). Cylindrical Zwitterionic Particles via Interpolyelectrolyte Complexation on Molecular Polymer Brushes. Macromolecular Rapid Communications, 42(8), Article 2000401. https://doi.org/10.1002/marc.202000401

The fabrication of macromolecular architectures with high aspect ratio and well‐defined internal and external morphologies remains a challenge. The combination of template chemistry and self‐assembly concepts to construct peculiar polymer architectur... Read More about Cylindrical Zwitterionic Particles via Interpolyelectrolyte Complexation on Molecular Polymer Brushes.

Highlights from Faraday Discussion 301: Nanolithography of Biointerfaces, London, UK, July 3–5 2019 (2019)
Journal Article
Mahon, C. S., & Huang, M. L. (2019). Highlights from Faraday Discussion 301: Nanolithography of Biointerfaces, London, UK, July 3–5 2019. Chemical Communications, 55(91), 13631-13637. https://doi.org/10.1039/c9cc90421b

The 2019 Faraday Discussion on the Nanolithography of Biointerfaces brought together a diverse set of interdisciplinary scientists involved in the seemingly disparate fields of materials science, nanolithography and glycoscience. The setting and form... Read More about Highlights from Faraday Discussion 301: Nanolithography of Biointerfaces, London, UK, July 3–5 2019.

A ‘catch-and-release’ receptor for the cholera toxin (2019)
Journal Article
Mahon, C. S., Wildsmith, G. C., Haksar, D., de Poel, E., Beekman, J. M., Pieters, R. J., Webb, M. E., & Turnbull, W. B. (2019). A ‘catch-and-release’ receptor for the cholera toxin. Faraday Discussions, 219, 112-127. https://doi.org/10.1039/c9fd00017h

Stimuli-responsive receptors for the recognition unit of the cholera toxin (CTB) have been prepared by attaching multiple copies of its natural carbohydrate ligand, the GM1 oligosaccharide, to a thermoresponsive polymer scaffold. Below their lower cr... Read More about A ‘catch-and-release’ receptor for the cholera toxin.

Molecular Recognition-Mediated Transformation of Single-Chain Polymer Nanoparticles into Crosslinked Polymer Films (2017)
Journal Article
Mahon, C. S., McGurk, C. J., Watson, S. M., Fascione, M. A., Sakonsinsiri, C., Turnbull, W. B., & Fulton, D. A. (2017). Molecular Recognition-Mediated Transformation of Single-Chain Polymer Nanoparticles into Crosslinked Polymer Films. Angewandte Chemie International Edition, 56(42), 12913-12918. https://doi.org/10.1002/anie.201706379

We describe single‐chain polymer nanoparticles (SCNPs) possessing intramolecular dynamic covalent crosslinks that can transform into polymer films through a molecular recognition‐mediated crosslinking process. The SCNPs utilise molecular recognition... Read More about Molecular Recognition-Mediated Transformation of Single-Chain Polymer Nanoparticles into Crosslinked Polymer Films.