All Outputs (4)

Coupling of the nucleus and cytoplasm: role of the LINC complex (2006)
Journal Article
Crisp, M., Liu, Q., Roux, K., Rattner, J., Shanahan, C., Burke, B., …Hodzic, D. (2006). Coupling of the nucleus and cytoplasm: role of the LINC complex. Journal of Cell Biology, 172(1), 41-53. https://doi.org/10.1083/jcb.200509124

The nuclear envelope defines the barrier between the nucleus and cytoplasm and features inner and outer membranes separated by a perinuclear space (PNS). The inner nuclear membrane contains specific integral proteins that include Sun1 and Sun2. Altho... Read More about Coupling of the nucleus and cytoplasm: role of the LINC complex.

Nup358 integrates nuclear envelope breakdown with kinetochore assembly (2003)
Journal Article
Salina, D., Enarson, P., Rattner, J., & Burke, B. (2003). Nup358 integrates nuclear envelope breakdown with kinetochore assembly. Journal of Cell Biology, 162(6), 991-1001. https://doi.org/10.1083/jcb.200304080

Nuclear envelope breakdown (NEBD) and release of condensed chromosomes into the cytoplasm are key events in the early stages of mitosis in metazoans. NEBD involves the disassembly of all major structural elements of the nuclear envelope, including nu... Read More about Nup358 integrates nuclear envelope breakdown with kinetochore assembly.

Cytoplasmic dynein as a facilitator of nuclear envelope breakdown (2002)
Journal Article
Salina, D., Bodoor, K., Eckley, D., Schroer, T., Rattner, J., & Burke, B. (2002). Cytoplasmic dynein as a facilitator of nuclear envelope breakdown. Cell, 108(1), 97-107. https://doi.org/10.1016/s0092-8674%2801%2900628-6

During prophase in higher cells, centrosomes localize to deep invaginations in the nuclear envelope in a microtubule-dependent process. Loss of nuclear membranes in prometaphase commences in regions of the nuclear envelope that lie outside of these i... Read More about Cytoplasmic dynein as a facilitator of nuclear envelope breakdown.

Nuclear envelope defects associated with LMNA mutations cause dilated cardiomyopathy and Emery-Dreifuss muscular dystrophy (2001)
Journal Article
Raharjo, W., Enarson, P., Sullivan, T., Stewart, C., & Burke, B. (2001). Nuclear envelope defects associated with LMNA mutations cause dilated cardiomyopathy and Emery-Dreifuss muscular dystrophy. Journal of Cell Science, 114(24), 4447-4457

Nuclear lamin A and C alleles that are linked to three distinct human diseases have been expressed both in HeLa cells and in fibroblasts derived from Lmna null mice. Point mutations that cause dilated cardiomyopathy (L85R and N195K) and autosomal dom... Read More about Nuclear envelope defects associated with LMNA mutations cause dilated cardiomyopathy and Emery-Dreifuss muscular dystrophy.