Skip to main content

Research Repository

Advanced Search

All Outputs (77)

Preventing Cardiac Damage in Patients Treated for Breast Cancer and Lymphoma: The PROACT Clinical Trial (2024)
Journal Article
Austin, D., Maier, R. H., Akhter, N., Sayari, M., Ogundimu, E., Maddox, J. M., Vahabi, S., Humphreys, A. C., Graham, J., Oxenham, H., Haney, S., Cresti, N., Verrill, M., Osborne, W., Wright, K. L., Goranova, R., Bailey, J. R., Kalakonda, N., Macheta, M., Kilner, M. F., …Plummer, C. (2024). Preventing Cardiac Damage in Patients Treated for Breast Cancer and Lymphoma: The PROACT Clinical Trial. Journal of the American College of Cardiology, 6(5), 684-696. https://doi.org/10.1016/j.jaccao.2024.07.010

Background
Cardiotoxicity is a concern for cancer survivors undergoing anthracycline chemotherapy. Enalapril has been explored for its potential to mitigate cardiotoxicity in cancer patients. The dose-dependent cardiotoxicity effec... Read More about Preventing Cardiac Damage in Patients Treated for Breast Cancer and Lymphoma: The PROACT Clinical Trial.

Nationally Automated Colonoscopy Performance Feedback Increases Polyp Detection: the NED APRIQOT Randomised Controlled Trial. (2024)
Journal Article
Catlow, J., Sharp, L., Wagnild, J., Lu, L., Bhardwaj-Gosling, R., Ogundimu, E., Kasim, A., Brookes, M., Lee, T., McCarthy, S., Gray, J., Sniehotta, F., Valori, R., Westwood, C., McNally, R., Ruwende, J., Sinclair, S., Deane, J., & Rutter, M. (2024). Nationally Automated Colonoscopy Performance Feedback Increases Polyp Detection: the NED APRIQOT Randomised Controlled Trial. Clinical Gastroenterology and Hepatology, 22(9), 1926-1936. https://doi.org/10.1016/j.cgh.2024.03.048

Post-colonoscopy colorectal cancer incidence and mortality rates are higher for endoscopists with low polyp detection rates. Using the UK's National Endoscopy Database (NED), which automatically captures real-time data, we assessed if providing feedb... Read More about Nationally Automated Colonoscopy Performance Feedback Increases Polyp Detection: the NED APRIQOT Randomised Controlled Trial..

The role of constraints and information gaps in driving risky medicine purchasing practices in four African countries. (2024)
Journal Article
Wagnild, J. M., Akhter, N., Lee, D., Jayeola, B., Darko, D. M., Adeyeye, M. C., …Hampshire, K. (2024). The role of constraints and information gaps in driving risky medicine purchasing practices in four African countries. Health Policy and Planning, 39(4), 372–386. https://doi.org/10.1093/heapol/czae006

Substandard and falsified (SF) medical products pose a major threat to public health and socioeconomic development, particularly in low- and middle-income countries. In response, public education campaigns have been developed to alert consumers to th... Read More about The role of constraints and information gaps in driving risky medicine purchasing practices in four African countries..

Modeling the positive testing rate of COVID-19 in South Africa using a semi-parametric smoother for binomial data (2023)
Journal Article
Owokotomo, O. E., Manda, S., Cleasen, J., Kasim, A., Sengupta, R., Shome, R., Subhra Paria, S., Reddy, T., & Shkedy, Z. (2023). Modeling the positive testing rate of COVID-19 in South Africa using a semi-parametric smoother for binomial data. Frontiers in Public Health, 11(2023), https://doi.org/10.3389/fpubh.2023.979230

Identification and isolation of COVID-19 infected persons plays a significant role in the control of COVID-19 pandemic. A country's COVID-19 positive testing rate is useful in understanding and monitoring the disease transmission and spread for the p... Read More about Modeling the positive testing rate of COVID-19 in South Africa using a semi-parametric smoother for binomial data.

Prehabilitation in elective patients undergoing cardiac surgery: a randomised control trial (THE PrEPS TRIAL) – a study protocol (2023)
Journal Article
Akowuah, E., Mathias, A., Bardgett, M., Harrison, S., Kasim, A. S., Loughran, K., Ogundimu, E., Trevis, J., Wagnild, J., Witharana, P., Hancock, H. C., & Maier, R. H. (2023). Prehabilitation in elective patients undergoing cardiac surgery: a randomised control trial (THE PrEPS TRIAL) – a study protocol. BMJ Open, 13(1), Article e065992. https://doi.org/10.1136/+bmjopen-2022-065992

Introduction: Prehabilitation prior to surgery has been shown to reduce postoperative complications, reduce length of hospital stay and improve quality of life after cancer and limb reconstruction surgery. However, there are minimal data on the impac... Read More about Prehabilitation in elective patients undergoing cardiac surgery: a randomised control trial (THE PrEPS TRIAL) – a study protocol.

Preventing cardiotoxicity in patients with breast cancer and lymphoma: protocol for a multicentre randomised controlled trial (PROACT) (2022)
Journal Article
Maier, R. H., Plummer, C., Kasim, A. S., Akhter, N., Ogundimu, E., Maddox, J., Graham, J., Stewart, M., Wardley, A., Haney, S., Vahabi, S., Oxenham, H., Humphreys, A., Cresti, N., Verrill, M., Graham, R., Chang, L., Hancock, H. C., & Austin, D. (2022). Preventing cardiotoxicity in patients with breast cancer and lymphoma: protocol for a multicentre randomised controlled trial (PROACT). BMJ Open, 12(12), Article e066252. https://doi.org/10.1136/bmjopen-2022-066252

Introduction: Anthracyclines are included in chemotherapy regimens to treat several different types of cancer and are extremely effective. However, it is recognised that a significant side effect is cardiotoxicity; anthracyclines can cause irreversib... Read More about Preventing cardiotoxicity in patients with breast cancer and lymphoma: protocol for a multicentre randomised controlled trial (PROACT).

Community empowerment and mental wellbeing: longitudinal findings from a survey of people actively involved in the big local place-based initiative in England (2022)
Journal Article
Akhter, N., McGowan, V., Halliday, E., Popay, J., Kasim, A., & Bambra, C. (2023). Community empowerment and mental wellbeing: longitudinal findings from a survey of people actively involved in the big local place-based initiative in England. Journal of Public Health, 45(2), 423–431. https://doi.org/10.1093/pubmed/fdac073

Background: Community empowerment initiatives are receiving increased interest as ways of improving health and reducing health inequalities. Purpose: Longitudinally examine associations between collective control, social-cohesion and mental wellbeing... Read More about Community empowerment and mental wellbeing: longitudinal findings from a survey of people actively involved in the big local place-based initiative in England.

Community health workers and health equity in low- and middle-income countries: systematic review and recommendations for policy and practice (2022)
Journal Article
Ahmed, S., Chase, L. E., Wagnild, J., Akhter, N., Sturridge, S., Clarke, A., Chowdhary, P., Mukami, D., Kasim, A., & Hampshire, K. (2022). Community health workers and health equity in low- and middle-income countries: systematic review and recommendations for policy and practice. International Journal for Equity in Health, 21(1), Article 49. https://doi.org/10.1186/s12939-021-01615-y

Background: The deployment of Community Health Workers (CHWs) is widely promoted as a strategy for reducing health inequities in low- and middle-income countries (LMIC). Yet there is limited evidence on whether and how CHW programmes achieve this. Th... Read More about Community health workers and health equity in low- and middle-income countries: systematic review and recommendations for policy and practice.

Fecal glucocorticoids and gastrointestinal parasite infections in wild western lowland gorillas (Gorilla gorilla gorilla) involved in ecotourism (2021)
Journal Article
Shutt-Phillips, K., Pafčo, B., Heistermann, M., Kasim, A., Petrželková, K. J., Profousová-Pšenková, I., Modrý, D., Todd, A., Fuh, T., Dicky, J.-F., Bopalanzognako, J.-B., & Setchell, J. M. (2021). Fecal glucocorticoids and gastrointestinal parasite infections in wild western lowland gorillas (Gorilla gorilla gorilla) involved in ecotourism. General and Comparative Endocrinology, 312, Article 113859. https://doi.org/10.1016/j.ygcen.2021.113859

Wildlife ecotourism can offer a source of revenue which benefits local development and conservation simultaneously. However, habituation of wildlife for ecotourism can cause long-term elevation of glucocorticoid hormones, which may suppress immune fu... Read More about Fecal glucocorticoids and gastrointestinal parasite infections in wild western lowland gorillas (Gorilla gorilla gorilla) involved in ecotourism.

Individual Participant Data Meta-analysis of the Impact of Educational Interventions on Pupils Eligible for Free School Meals (2021)
Journal Article
Ashraf, B., Singh, A., Uwimpuhwe, G., Higgins, S., & Kasim, A. (2021). Individual Participant Data Meta-analysis of the Impact of Educational Interventions on Pupils Eligible for Free School Meals. British Educational Research Journal, 47(6), 1675-1699. https://doi.org/10.1002/berj.3749

Meta-analysis is the synthesis of findings from research projects, which enables an estimate of the average or pooled effect across various studies. This study presents findings from the intention to treat analysis for a series of educational evaluat... Read More about Individual Participant Data Meta-analysis of the Impact of Educational Interventions on Pupils Eligible for Free School Meals.

Risk factors for Non-Communicable Diseases Related to Obesity among First- and Second-Generation Bangladeshi Migrants Living in North-east or South-east England (2021)
Journal Article
Akhter, N., Begum, K., Nahar, P., Cooper, G., Vallis, D., Kasim, A., & Bentley, G. R. (2021). Risk factors for Non-Communicable Diseases Related to Obesity among First- and Second-Generation Bangladeshi Migrants Living in North-east or South-east England. International Journal of Obesity, 45(7), 1588-1598. https://doi.org/10.1038/s41366-021-00822-5

Background: Obesity is a global burden, which significantly increases the risk of non-communicable diseases (NCDs). More than a quarter of adults in the United Kingdom are obese, but prevalence varies by ethnicity, and South Asians have the largest b... Read More about Risk factors for Non-Communicable Diseases Related to Obesity among First- and Second-Generation Bangladeshi Migrants Living in North-east or South-east England.

Multisite educational trials: estimating the effect size and its confidence intervals (2021)
Journal Article
Singh, A., Uwimpuhwe, G., Li, M., Einbeck, J., Higgins, S., & Kasim, A. (2022). Multisite educational trials: estimating the effect size and its confidence intervals. International Journal of Research & Method in Education, 45(1), 18-38. https://doi.org/10.1080/1743727x.2021.1882416

In education, multisite trials involve randomisation of pupils into intervention and comparison groups within schools. Most analytical models in multisite educational trials ignore that the impact of an intervention may be school dependent. This stud... Read More about Multisite educational trials: estimating the effect size and its confidence intervals.

Mini-sternotomy versus conventional sternotomy for aortic valve replacement: a randomised controlled trial (2021)
Journal Article
Hancock, H. C., Maier, R. H., Kasim, A., Mason, J., Murphy, G., Goodwin, A., Owens, W. A., & Akowuah, E. (2021). Mini-sternotomy versus conventional sternotomy for aortic valve replacement: a randomised controlled trial. BMJ Open, 11(1), Article e041398. https://doi.org/10.1136/bmjopen-2020-041398

Objective: To compare clinical and health economic outcomes after manubrium-limited mini-sternotomy (intervention) and conventional median sternotomy (usual care). Design: A single-blind, randomised controlled trial. Setting: Single centre UK Nationa... Read More about Mini-sternotomy versus conventional sternotomy for aortic valve replacement: a randomised controlled trial.

Informal mhealth at scale in Africa: Opportunities and challenges (2021)
Journal Article
Hampshire, K., Mwase-Vuma, T., Alemu, K., Abane, A., Munthali, A., Awoke, T., Mariwah, S., Chamdimba, E., Owusu, S. A., Robson, E., Castelli, M., Shkedy, Z., Shawa, N., Abel, J., & Kasim, A. (2021). Informal mhealth at scale in Africa: Opportunities and challenges. World Development, 140, https://doi.org/10.1016/j.worlddev.2020.105257

The extraordinary global growth of digital connectivity has generated optimism that mobile technologies can help overcome infrastructural barriers to development, with ‘mobile health’ (mhealth) being a key component of this. However, while ‘formal’ (... Read More about Informal mhealth at scale in Africa: Opportunities and challenges.

Formalising ‘informal’ mHealth in Ghana: Opportunities and challenges for Universal Health Coverage (UHC) (2021)
Journal Article
Mariwah, S., Machistey Abane, A., Asiedu Owusu, S., Kasim, A., Robson, E., Castelli, M., & Hampshire, K. (2022). Formalising ‘informal’ mHealth in Ghana: Opportunities and challenges for Universal Health Coverage (UHC). Global Public Health, 17(5), 768-781. https://doi.org/10.1080/17441692.2021.1874467

While mobile phones promise to be an important tool for bridging the healthcare gaps in resource-poor areas in developing countries, scalability and sustainability of mobile phones for health (mhealth) interventions still remain a major challenge. Me... Read More about Formalising ‘informal’ mHealth in Ghana: Opportunities and challenges for Universal Health Coverage (UHC).

Collective control, social-cohesion and health and wellbeing: Baseline survey results from the Communities in Control Study in England (2021)
Journal Article
McGowan, V., Akhter, N., Halliday, E., Popay, J., Kasim, A., & Bambra, C. (2022). Collective control, social-cohesion and health and wellbeing: Baseline survey results from the Communities in Control Study in England. Journal of Public Health, 44(2), 378-386. https://doi.org/10.1093/pubmed/fdaa227

Background: Area-based initiatives (ABIs) are receiving renewed interest as part of ‘place-based public health’ approaches to reducing health inequalities. Purpose: Examine associations between collective control, social-cohesion and health amongst r... Read More about Collective control, social-cohesion and health and wellbeing: Baseline survey results from the Communities in Control Study in England.

Application of Bayesian posterior probabilistic inference in educational trials (2020)
Journal Article
Uwimpuhwe, G., Singh, A., Higgins, S., & Kasim, A. (2021). Application of Bayesian posterior probabilistic inference in educational trials. International Journal of Research & Method in Education, 44(5), 533-554. https://doi.org/10.1080/1743727X.2020.1856067

Educational researchers advocate the use of an effect size and its confidence interval to assess the effectiveness of interventions instead of relying on a p-value, which has been blamed for lack of reproducibility of research findings and the misuse... Read More about Application of Bayesian posterior probabilistic inference in educational trials.

Telomerase Activation to Reverse Immunosenescence in Elderly Patients With Acute Coronary Syndrome: Protocol for a Randomized Pilot Trial (2020)
Journal Article
Maier, R., Bawamia, B., Bennaceur, K., Dunn, S., Marsay, L., Amoah, R., Kasim, A., Filby, A., Austin, D., Hancock, H., & Spyridopoulos, I. (2020). Telomerase Activation to Reverse Immunosenescence in Elderly Patients With Acute Coronary Syndrome: Protocol for a Randomized Pilot Trial. JMIR Research Protocols, 9(9), Article e19456. https://doi.org/10.2196/19456

Background: Inflammation plays a key role in the pathophysiology of coronary heart disease (CHD) and its acute manifestation, acute coronary syndrome (ACS). Aging is associated with a decline of the immune system, a process known as immunosenescence.... Read More about Telomerase Activation to Reverse Immunosenescence in Elderly Patients With Acute Coronary Syndrome: Protocol for a Randomized Pilot Trial.

The Northumberland Exercise Referral Scheme as a universal community weight management programme: a mixed methods exploration of outcomes, expectations and experiences across a social gradient (2020)
Journal Article
Dodd-Reynolds, C., Vallis, D., Kasim, A., Akhter, N., & Hanson, C. (2020). The Northumberland Exercise Referral Scheme as a universal community weight management programme: a mixed methods exploration of outcomes, expectations and experiences across a social gradient. International Journal of Environmental Research and Public Health, 17(15), Article 5297. https://doi.org/10.3390/ijerph17155297

Exercise referral schemes (ERS) are internationally recognised, yet little attention has been paid to discrete referral groups or the influence of wider social determinants of health. The primary quantitative element of this mixed methods study used... Read More about The Northumberland Exercise Referral Scheme as a universal community weight management programme: a mixed methods exploration of outcomes, expectations and experiences across a social gradient.