Is CFTR-delF508 Really Absent from the Apical Membrane of the Airway Epithelium?

Borthwick, L.A.; Botha, P.; Verdon, B.; Brodlie, M.J.; Gardner, A.; Bourn, D.; Johnson, G.E.; Gray, M.A.; Fisher, A.J.

doi:10.1371/journal.pone.0023226

All Outputs (2)

Generation and characterization of multipotent stem cells from established dermal cultures (2012)
Journal Article
Hill, R., Gledhill, K., Gardner, A., Higgins, C., Crawford, H., Lawrence, C., …Jahoda, C. (2012). Generation and characterization of multipotent stem cells from established dermal cultures. PLoS ONE, 7(11), https://doi.org/10.1371/journal.pone.0050742

Human multipotent skin derived precursor cells (SKPs) are traditionally sourced from dissociated dermal tissues; therefore, donor availability may become limiting. Here we demonstrate that both normal and diseased adult human dermal fibroblasts (DF)... Read More about Generation and characterization of multipotent stem cells from established dermal cultures.

Is CFTR-delF508 Really Absent from the Apical Membrane of the Airway Epithelium? (2011)
Journal Article
Borthwick, L., Botha, P., Verdon, B., Brodlie, M., Gardner, A., Bourn, D., …Fisher, A. (2011). Is CFTR-delF508 Really Absent from the Apical Membrane of the Airway Epithelium?. PLoS ONE, 6(8), https://doi.org/10.1371/journal.pone.0023226

Background Understanding where mutant CFTR is localised in airway epithelia is essential in guiding the best therapeutic approach to correct the dysfunction of the CFTR protein. The widely held paradigm is that CF patients harbouring the commonest mu... Read More about Is CFTR-delF508 Really Absent from the Apical Membrane of the Airway Epithelium?.