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Xenobiotic responsiveness of Arabidopsis thaliana to a chemical series derived from a herbicide safener (2011)
Journal Article
Skipsey, M., Knight, K., Brazier-Hicks, M., Dixon, D., Steel, P., & Edwards, R. (2011). Xenobiotic responsiveness of Arabidopsis thaliana to a chemical series derived from a herbicide safener. Journal of Biological Chemistry, 286(37), 32268-32276. https://doi.org/10.1074/jbc.m111.252726

Plants respond to synthetic chemicals by eliciting a xenobiotic response (XR) which enhances the expression of detoxifying enzymes, such as glutathione transferases (GSTs). In agrochemistry, the ability of safeners to induce an XR is used to increase... Read More about Xenobiotic responsiveness of Arabidopsis thaliana to a chemical series derived from a herbicide safener.

The Arabidopsis phi class glutathione transferase AtGSTF2: binding and regulation by biologically active heterocyclic ligands (2011)
Journal Article
Dixon, D., Sellars, J., & Edwards, R. (2011). The Arabidopsis phi class glutathione transferase AtGSTF2: binding and regulation by biologically active heterocyclic ligands. Biochemical Journal, 438(1), 63-70. https://doi.org/10.1042/bj20101884

The plant-specific phi class of glutathione transferases (GSTFs) are often highly stress-inducible and expressed in a tissue-specific manner, suggestive of them having important protective roles. To date, these functions remain largely unknown, altho... Read More about The Arabidopsis phi class glutathione transferase AtGSTF2: binding and regulation by biologically active heterocyclic ligands.

Multiple roles for plant glutathione transferases in xenobiotic detoxification (2011)
Journal Article
Cummins, I., Dixon, D., Freitag-Pohl, S., Skipsey, M., & Edwards, R. (2011). Multiple roles for plant glutathione transferases in xenobiotic detoxification. Drug Metabolism Reviews, 43(2), 266-280. https://doi.org/10.3109/03602532.2011.552910

Discovered 40 years ago, plant glutathione transferases (GSTs) now have a well-established role in determining herbicide metabolism and selectivity in crops and weeds. Within the GST superfamily, the numerous and plant-specific phi (F) and tau (U) cl... Read More about Multiple roles for plant glutathione transferases in xenobiotic detoxification.