Skip to main content

Research Repository

Advanced Search

All Outputs (94)

Molecular design of a splicing switch responsive to the RNA binding protein Tra2β (2011)
Journal Article
Grellscheid, S., Dalgliesh, C., Rozanska, A., Grellscheid, D., Bourgeois, C., Stévenin, J., & Elliott, D. (2011). Molecular design of a splicing switch responsive to the RNA binding protein Tra2β. Nucleic Acids Research, 39(18), 8092-8104. https://doi.org/10.1093/nar/gkr495

Tra2β regulates a number of splicing switches including activation of the human testis-specific exon HIPK3-T in the Homeodomain Interacting Protein Kinase 3 gene. By testing HIPK3-T exons of different intrinsic strengths, we found Tra2β most efficien... Read More about Molecular design of a splicing switch responsive to the RNA binding protein Tra2β.

Multiple TGF-β superfamily signals modulate the adult Drosophila immune response (2011)
Journal Article
Clark, R., Woodcock, K., Geissmann, F., Trouillet, C., & Dionne, M. (2011). Multiple TGF-β superfamily signals modulate the adult Drosophila immune response. Current Biology, 21(19), 1672-1677. https://doi.org/10.1016/j.cub.2011.08.048

TGF-β superfamily signals play complex roles in regulation of tissue repair and inflammation in mammals [1]. Drosophila melanogaster is a well-established model for the study of innate immune function [2, 3] and wound healing [4–7]. Here, we explore... Read More about Multiple TGF-β superfamily signals modulate the adult Drosophila immune response.

Endocytosis and sphingolipid scavenging in Leishmania mexicana amastigotes (2011)
Journal Article
Ali, H., Harding, C., & Denny, P. (2012). Endocytosis and sphingolipid scavenging in Leishmania mexicana amastigotes. Biochemistry Research International, 2012, Article 691363. https://doi.org/10.1155/2012/691363

Leishmania species are the causative agents of the leishmaniases, a spectrum of neglected tropical diseases. Amastigote stage parasites exist within macrophages and scavenge host factors for survival, for example, Leishmania species utilise host sphi... Read More about Endocytosis and sphingolipid scavenging in Leishmania mexicana amastigotes.

Environmental factors associated with genetic and phenotypic divergence among sympatric populations of Arctic charr (Salvelinus alpinus) (2011)
Journal Article
Corrigan, L., Lucas, M., Winfield, I., & Hoelzel, A. (2011). Environmental factors associated with genetic and phenotypic divergence among sympatric populations of Arctic charr (Salvelinus alpinus). Journal of Evolutionary Biology, 24(9), 1906-1917. https://doi.org/10.1111/j.1420-9101.2011.02327.x

The mechanisms by which phenotypic and genetic divergence may occur among sympatric, conspecific populations have been widely discussed but are still not well understood. Possible mechanisms include assortative mating based on morphology or variation... Read More about Environmental factors associated with genetic and phenotypic divergence among sympatric populations of Arctic charr (Salvelinus alpinus).

OsSFR6 is a functional rice orthologue of SENSITIVE TO FREEZING-6 and can act as a regulator of COR gene expression, osmotic stress and freezing tolerance in Arabidopsis (2011)
Journal Article
Wathugala, D., Richards, S., Knight, H., & Knight, M. (2011). OsSFR6 is a functional rice orthologue of SENSITIVE TO FREEZING-6 and can act as a regulator of COR gene expression, osmotic stress and freezing tolerance in Arabidopsis. New Phytologist, 191(4), 984-995. https://doi.org/10.1111/j.1469-8137.2011.03759.x

The Arabidopsis protein SENSITIVE TO FREEZING-6 (AtSFR6) is required for cold- and drought-inducible expression of COLD-ON REGULATED (COR) genes and, as a consequence, AtSFR6 is essential for osmotic stress and freezing tolerance in Arabidopsis. Ther... Read More about OsSFR6 is a functional rice orthologue of SENSITIVE TO FREEZING-6 and can act as a regulator of COR gene expression, osmotic stress and freezing tolerance in Arabidopsis.

Components of Complex Lipid Biosynthetic Pathways in Developing Castor (Ricinus communis) Seeds Identified by MudPIT Analysis of Enriched Endoplasmic Reticulum (2011)
Journal Article
Brown, A., Kroon, J., Topping, J., Robson, J., Simon, W., & Slabas, A. (2011). Components of Complex Lipid Biosynthetic Pathways in Developing Castor (Ricinus communis) Seeds Identified by MudPIT Analysis of Enriched Endoplasmic Reticulum. Journal of Proteome Research, 10(8), 3565-3577. https://doi.org/10.1021/pr2002066

Studies on the antileishmanial properties of the antimicrobial peptides temporin A, B and 1Sa (2011)
Journal Article
Chadbourne, F., Raleigh, C., Ali, H., Denny, P., & Cobb, S. (2011). Studies on the antileishmanial properties of the antimicrobial peptides temporin A, B and 1Sa. Journal of Peptide Science, 17(11), 751-755. https://doi.org/10.1002/psc.1398

Given the paucity and toxicity of available drugs for leishmaniasis, coupled with the advent of drug resistance, the discovery of new therapies for this neglected tropical disease is recognised as being of the utmost urgency. As such antimicrobial pe... Read More about Studies on the antileishmanial properties of the antimicrobial peptides temporin A, B and 1Sa.

Carbon balance of Arctic tundra under increased snow cover mediated by a plant pathogen (2011)
Journal Article
Olofsson, J., Ericson, L., Torp, M., Stark, S., & Baxter, R. (2011). Carbon balance of Arctic tundra under increased snow cover mediated by a plant pathogen. Nature Climate Change, 1(4), 220-223. https://doi.org/10.1038/nclimate1142

Climate change is affecting plant community composition(1) and ecosystem structure, with consequences for ecosystem processes such as carbon storage(2-4). Climate can affect plants directly by altering growth rates(1), and indirectly by affecting pre... Read More about Carbon balance of Arctic tundra under increased snow cover mediated by a plant pathogen.

Evidence for the assembly of a bacterial tripartite multidrug pump with a stoichiometry of 3:6:3 (2011)
Journal Article
Janganan, T., Bavro, V., Zhang, L., Matak-Vinkovic, D., Barrera, N., Venien-Bryan, C., …Walmsley, A. (2011). Evidence for the assembly of a bacterial tripartite multidrug pump with a stoichiometry of 3:6:3. Journal of Biological Chemistry, 286(30), 26900-26912. https://doi.org/10.1074/jbc.m111.246595

The multiple transferable resistance (mTR) pump from Neisseria gonorrhoeae MtrCDE multidrug pump is assembled from the inner and outer membrane proteins MtrD and MtrE and the periplasmic membrane fusion protein MtrC. Previously we established that wh... Read More about Evidence for the assembly of a bacterial tripartite multidrug pump with a stoichiometry of 3:6:3.

To assess whether indoor residual spraying can provide additional protection against clinical malaria over current best practice of long-lasting insecticidal mosquito nets in The Gambia: study protocol for a two-armed cluster-randomised study (2011)
Journal Article
Pinder, M., Jawara, M., Jarju, L., Ballah, K., Jeffries, D., Lluberas, M., …Lindsay, S. (2011). To assess whether indoor residual spraying can provide additional protection against clinical malaria over current best practice of long-lasting insecticidal mosquito nets in The Gambia: study protocol for a two-armed cluster-randomised study. Trials, 12, https://doi.org/10.1186/1745-6215-12-147

Background: Recently, there has been mounting interest in scaling-up vector control against malaria in Africa. It needs to be determined if indoor residual spraying (IRS with DDT) will provide significant marginal protection against malaria over curr... Read More about To assess whether indoor residual spraying can provide additional protection against clinical malaria over current best practice of long-lasting insecticidal mosquito nets in The Gambia: study protocol for a two-armed cluster-randomised study.

Gauging weirs impede the upstream migration of adult river lamprey Lampetra fluviatilis (2011)
Journal Article
Russon, I., Kemp, P., & Lucas, M. (2011). Gauging weirs impede the upstream migration of adult river lamprey Lampetra fluviatilis. Fisheries Management and Ecology, 18(3), 201-210. https://doi.org/10.1111/j.1365-2400.2010.00778.x

The ability of individual and groups of 30 migrating adult river lamprey Lampetra fluviatilis L. to pass a Crump or flat-v gauging weir under two discharge regimes (moderate and low) was assessed in an experimental channel. Despite repeated attempts... Read More about Gauging weirs impede the upstream migration of adult river lamprey Lampetra fluviatilis.

An introduction to biological nuclear magnetic resonance spectroscopy (2011)
Journal Article
Bothwell, J. H., & Griffin, J. L. (2011). An introduction to biological nuclear magnetic resonance spectroscopy. Biological Reviews, 86(2), 493-510. https://doi.org/10.1111/j.1469-185x.2010.00157.x

Nuclear magnetic resonance (NMR) spectroscopy is one of the most powerful analytical techniques available to biology. This review is an introduction to the potential of this method and is aimed at readers who have little or no experience in acquiring... Read More about An introduction to biological nuclear magnetic resonance spectroscopy.

The influence of discharge and temperature on the ability of upstream migrant adult river lamprey (Lampetra fluviatilis) to pass experimental overshot and undershot weirs (2011)
Journal Article
Kemp, P., Russon, I., Vowles, A., & Lucas, M. (2011). The influence of discharge and temperature on the ability of upstream migrant adult river lamprey (Lampetra fluviatilis) to pass experimental overshot and undershot weirs. River Research and Applications, 27(4), 488-498. https://doi.org/10.1002/rra.1364

The efficiencies of fish passes specifically designed and constructed to facilitate the movement of a limited number of species and life-stages past structural barriers are likely to decline as site-specific conditions shift with a changing climate.... Read More about The influence of discharge and temperature on the ability of upstream migrant adult river lamprey (Lampetra fluviatilis) to pass experimental overshot and undershot weirs.

Towards the creation of a systems tip growth model for a pollen tube. (2011)
Journal Article
Liu, J., & Hussey, P. (2011). Towards the creation of a systems tip growth model for a pollen tube. Plant Signaling & Behavior, 6(4), 520-522. https://doi.org/10.4161/psb.6.4.14750

Essential features of pollen tube growth are polarization of extracellular ion fluxes, intracellular ion gradients, and oscillating dynamics. These features in pollen tube growth are regulated by a wide range of spatiotemporally organized functions s... Read More about Towards the creation of a systems tip growth model for a pollen tube..

A Flow Cytometry-Based Screen of Nuclear Envelope Transmembrane Proteins Identifies NET4/Tmem53 as Involved in Stress-Dependent Cell Cycle Withdrawal (2011)
Journal Article
Korfali, N., Srsen, V., Waterfall, M., Batrakou, D. G., Pekovic, V., Hutchison, C. J., & Schirmer, E. C. (2011). A Flow Cytometry-Based Screen of Nuclear Envelope Transmembrane Proteins Identifies NET4/Tmem53 as Involved in Stress-Dependent Cell Cycle Withdrawal. PLoS ONE, 6(4), Article e18762. https://doi.org/10.1371/journal.pone.0018762

Disruption of cell cycle regulation is one mechanism proposed for how nuclear envelope protein mutation can cause disease. Thus far only a few nuclear envelope proteins have been tested/found to affect cell cycle progression: to identify others, 39 n... Read More about A Flow Cytometry-Based Screen of Nuclear Envelope Transmembrane Proteins Identifies NET4/Tmem53 as Involved in Stress-Dependent Cell Cycle Withdrawal.

Embryonic and adult isoforms of XLAP2 form microdomains associated with chromatin and the nuclear envelope (2011)
Journal Article
Chmielewska, M., Dubińska-Magiera, M., Sopel, M., Rzepecka, D., Hutchison, C., Goldberg, M., & Rzepecki, R. (2011). Embryonic and adult isoforms of XLAP2 form microdomains associated with chromatin and the nuclear envelope. Cell and Tissue Research, 344(1), 97-110. https://doi.org/10.1007/s00441-011-1129-2

Laminin-associated polypeptide 2 (LAP2) proteins are alternatively spliced products of a single gene; they belong to the LEM domain family and, in mammals, locate to the nuclear envelope (NE) and nuclear lamina. Isoforms lacking the transmembrane dom... Read More about Embryonic and adult isoforms of XLAP2 form microdomains associated with chromatin and the nuclear envelope.

Maximum relative growth rate of common UK plant species is positively associated with their global invasiveness. (2011)
Journal Article
Dawson, W., Fischer, M., & van Kleunen, M. (2011). Maximum relative growth rate of common UK plant species is positively associated with their global invasiveness. Global Ecology and Biogeography, 20(2), 299-306. https://doi.org/10.1111/j.1466-8238.2010.00599.x

Aim  An emerging consensus in invasion ecology is that faster-growing alien plant species tend to be more invasive than slower-growing species. However, phylogenetic non-independence and the precision of growth-rate measures often remain unaccounted... Read More about Maximum relative growth rate of common UK plant species is positively associated with their global invasiveness..