All Outputs (3)

Identification of novel androgen-regulated pathways and mRNA isoforms through genome-wide exon-specific profiling of the LNCaP transcriptome (2011)
Journal Article
Rajan, P., Dalgliesh, C., Carling, P., Buist, T., Zhang, C., Grellscheid, S., …Elliott, D. (2011). Identification of novel androgen-regulated pathways and mRNA isoforms through genome-wide exon-specific profiling of the LNCaP transcriptome. PLoS ONE, 6(12), Article e29088. https://doi.org/10.1371/journal.pone.0029088

Androgens drive the onset and progression of prostate cancer (PCa) by modulating androgen receptor (AR) transcriptional activity. Although several microarray-based studies have identified androgen-regulated genes, here we identify in-parallel global... Read More about Identification of novel androgen-regulated pathways and mRNA isoforms through genome-wide exon-specific profiling of the LNCaP transcriptome.

Identification of evolutionarily conserved exons as regulated targets for the splicing activator tra2β in development (2011)
Journal Article
Grellscheid, S., Dalgliesh, C., Storbeck, M., Best, A., Liu, Y., Jakubik, M., Mende, Y., Ehrmann, I., Curk, T., Rossbach, K., Bourgeois, C. F., Stévenin, J., Grellscheid, D., Jackson, M. S., Wirth, B., & Elliott, D. J. (2011). Identification of evolutionarily conserved exons as regulated targets for the splicing activator tra2β in development. PLoS Genetics, 7(12), Article e1002390. https://doi.org/10.1371/journal.pgen.1002390

Alternative splicing amplifies the information content of the genome, creating multiple mRNA isoforms from single genes. The evolutionarily conserved splicing activator Tra2β (Sfrs10) is essential for mouse embryogenesis and implicated in spermatogen... Read More about Identification of evolutionarily conserved exons as regulated targets for the splicing activator tra2β in development.

Molecular design of a splicing switch responsive to the RNA binding protein Tra2β (2011)
Journal Article
Grellscheid, S., Dalgliesh, C., Rozanska, A., Grellscheid, D., Bourgeois, C., Stévenin, J., & Elliott, D. (2011). Molecular design of a splicing switch responsive to the RNA binding protein Tra2β. Nucleic Acids Research, 39(18), 8092-8104. https://doi.org/10.1093/nar/gkr495

Tra2β regulates a number of splicing switches including activation of the human testis-specific exon HIPK3-T in the Homeodomain Interacting Protein Kinase 3 gene. By testing HIPK3-T exons of different intrinsic strengths, we found Tra2β most efficien... Read More about Molecular design of a splicing switch responsive to the RNA binding protein Tra2β.