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Iridium Complexes as a Roadblock for DNA Polymerase during Amplification

Chandra, Falguni; Kumar, Prashant; Tripathi, Suman Kumar; Patra, Srikanta; Koner, Apurba L.

Authors

Falguni Chandra

Suman Kumar Tripathi

Srikanta Patra

Apurba L. Koner



Abstract

Iridium-based metal complexes containing polypyridyl-pyrazine ligands show properties of DNA intercalation. They serve as roadblocks to DNA polymerase activity, thereby inhibiting the polymerization process. Upon the addition of increasing concentrations of these iridium complexes, a rapid polymerase chain reaction (PCR)-based assay reveals the selective inhibition of the DNA polymerization process. This label-free approach to study the inhibition of fundamental cellular processes via physical roadblock can offer an alternative route toward cancer therapy.

Citation

Chandra, F., Kumar, P., Tripathi, S. K., Patra, S., & Koner, A. L. (2016). Iridium Complexes as a Roadblock for DNA Polymerase during Amplification. ChemMedChem, 11(13), 1410-1414. https://doi.org/10.1002/cmdc.201600101

Journal Article Type Article
Acceptance Date Feb 16, 2016
Online Publication Date May 31, 2016
Publication Date Jul 5, 2016
Deposit Date Jul 10, 2024
Journal ChemMedChem
Print ISSN 1860-7179
Electronic ISSN 1860-7187
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 11
Issue 13
Pages 1410-1414
DOI https://doi.org/10.1002/cmdc.201600101
Public URL https://durham-repository.worktribe.com/output/2523550
Additional Information Estimated acceptance date