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Iridium Complexes as a Roadblock for DNA Polymerase during Amplification

Chandra, Falguni; Kumar, Prashant; Tripathi, Suman Kumar; Patra, Srikanta; Koner, Apurba L.


Falguni Chandra

Suman Kumar Tripathi

Srikanta Patra

Apurba L. Koner


Iridium-based metal complexes containing polypyridyl-pyrazine ligands show properties of DNA intercalation. They serve as roadblocks to DNA polymerase activity, thereby inhibiting the polymerization process. Upon the addition of increasing concentrations of these iridium complexes, a rapid polymerase chain reaction (PCR)-based assay reveals the selective inhibition of the DNA polymerization process. This label-free approach to study the inhibition of fundamental cellular processes via physical roadblock can offer an alternative route toward cancer therapy.


Chandra, F., Kumar, P., Tripathi, S. K., Patra, S., & Koner, A. L. (2016). Iridium Complexes as a Roadblock for DNA Polymerase during Amplification. ChemMedChem, 11(13), 1410-1414.

Journal Article Type Article
Acceptance Date Feb 16, 2016
Online Publication Date May 31, 2016
Publication Date Jul 5, 2016
Deposit Date Jul 10, 2024
Journal ChemMedChem
Print ISSN 1860-7179
Electronic ISSN 1860-7187
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 11
Issue 13
Pages 1410-1414
Public URL
Additional Information Estimated acceptance date