The redox-responsive roles of intermediate filaments in cellular stress detection, integration and mitigation

Pérez-Sala, Dolores; Quinlan, Roy A.

Abstract

Intermediate filaments are critical for cell and tissue homeostasis and for stress responses. Cytoplasmic intermediate filaments form versatile and dynamic assemblies that interconnect cellular organelles, participate in signaling and protect cells and tissues against stress. Here we have focused on their involvement in redox signaling and oxidative stress, which arises in numerous pathophysiological situations. We pay special attention to type III intermediate filaments, mainly vimentin, because it provides a physical interface for redox signaling, stress responses and mechanosensing. Vimentin possesses a single cysteine residue that is a target for multiple oxidants and electrophiles. This conserved residue fine tunes vimentin assembly, response to oxidative stress and crosstalk with other cellular structures. Here we integrate evidence from the intermediate filament and redox biology fields to propose intermediate filaments as redox sentinel networks of the cell. To support this, we appraise how vimentin detects and orchestrates cellular responses to oxidative and electrophilic stress.

Citation

Pérez-Sala, D., & Quinlan, R. A. (2024). The redox-responsive roles of intermediate filaments in cellular stress detection, integration and mitigation. Current Opinion in Cell Biology, 86, Article 102283. https://doi.org/10.1016/j.ceb.2023.102283

• Journal Article Type: Article
• Acceptance Date: Oct 29, 2023
• Online Publication Date: Nov 20, 2023
• Publication Date: 2024-02
• Deposit Date: Nov 29, 2023
• Publicly Available Date: Nov 29, 2023
• Journal: Current Opinion in Cell Biology
• Print ISSN: 0955-0674
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 86
• Article Number: 102283
• DOI: https://doi.org/10.1016/j.ceb.2023.102283
• Public URL: https://durham-repository.worktribe.com/output/1949498