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A novel repeated DNA sequence located in the intergenic regions of bacterial chromosomes.

Sharples, G.J.; Lloyd, R.G.

Authors

R.G. Lloyd



Abstract

We report the discovery of a novel group of highly conserved DNA sequences located within the intergenic regions of the chromosomes of Escherichia coli, Salmonella typhimurium and other bacteria. These intergenic repeat units (IRUs) are 124-127 nucleotides long and have the potential to form stable stem-loop structures. The location of these sequences within the intergenic regions is variable with respect to known or putative signals for transcription and translation of the flanking genes. Some of the IRU sequences are transcribed, others are probably not. The structure and possible functions of these sequences are discussed in relation to palindromic units and other repeated DNA sequences in bacteria.

Citation

Sharples, G., & Lloyd, R. (1990). A novel repeated DNA sequence located in the intergenic regions of bacterial chromosomes. Nucleic Acids Research, 18(22), 6503-6508

Journal Article Type Article
Publication Date 1990
Journal Nucleic Acids Research
Print ISSN 0305-1048
Publisher Oxford University Press
Volume 18
Issue 22
Pages 6503-6508
Public URL https://durham-repository.worktribe.com/output/1559603
Publisher URL http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2251112