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Hair follicle dermal sheath cells: unsung participants in wound healing

Jahoda, CAB; Reynolds, AJ


AJ Reynolds


The dermal sheath that surrounds the outside of the hair follicle contains progenitor cells that maintain and regenerate the dermal papilla, a key component for hair growth. Our contention is that dermal sheath cells have other roles. We believe that they can become wound healing fibroblasts and perform an important function in the repair of skin dermis after injury. The dermal sheath has close developmental and anatomical parallels with follicle outer root sheath, the epithelial component that contains the stem cells responsible for replacing skin epidermis. Dermal sheath cells also have a myofibroblast or wound healing phenotype, and in animals with high follicle densities differences in wound healing are observed in conjunction with changes in the hair growth cycle. Similarly, in human beings there are apparent differences in wound healing responses between hairy and non-hairy body sites. Moreover, clinical and experimental data suggest that the involvement of follicle-derived dermal cells results in qualitatively improved dermal repair. Therefore, in a therapeutic context, hair follicle dermal cells provide an accessible option for the creation of dermal or full skin equivalents that could both improve wound healing and reduce scarring. Indeed, given the inductive properties of adult hair follicle dermal cells, it is reasonable to envisage a tissue engineering approach for the production of a skin equivalent that will grow hair follicles when grafted.


Jahoda, C., & Reynolds, A. (2001). Hair follicle dermal sheath cells: unsung participants in wound healing. The Lancet, 358(9291), 1445-1448.

Journal Article Type Article
Publication Date Oct 27, 2001
Deposit Date Feb 10, 2009
Journal The Lancet
Print ISSN 0140-6736
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 358
Issue 9291
Pages 1445-1448