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A Gramicidin Analogue that Exhibits Redox Potential Dependent Cation Influx

Jackson, T.J.; Sanderson, J.M.; Kataky, R.


T.J. Jackson


A synthetic analogue of gramicidin A, gram-2-(nicotinamidyl)ethyl carbamate (gAN) was found to regulate the influx of potassium ions depending on its redox state. At potentials less than −0.52 (±0.05) V, the nicotinamide group in gAN is reduced and allows charge- and size-selective influx of cations. In the oxidised state, charge repulsion between the positively charged nicotinamide group and the cations prevents any influx of cations. Chronoamperometric experiments were conducted to determine permeabilities of Eu3+, Tl+, K+ ions in a BLM porated with gAN. Scanning electrochemical microscopy (SECM) experiments were conducted with two ions: permeant K+ ions and the larger (CH3)4N+ ion which blocks the channel. The switching potential for gAN, at which the channel allows flux monovalent cations, is shown to be potential and pH-dependent and temperature-independent.


Jackson, T., Sanderson, J., & Kataky, R. (2008). A Gramicidin Analogue that Exhibits Redox Potential Dependent Cation Influx. Sensors and Actuators B: Chemical, 130(2), 630-637.

Journal Article Type Article
Acceptance Date Oct 16, 2007
Online Publication Date Oct 23, 2007
Publication Date Mar 28, 2008
Deposit Date Jun 21, 2011
Publicly Available Date Jan 3, 2012
Journal Sensors and Actuators B: Chemical
Print ISSN 0925-4005
Publisher Elsevier
Peer Reviewed Not Peer Reviewed
Volume 130
Issue 2
Pages 630-637


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