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The role of co-crystals in pharmaceutical design

Steed, J.W.

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Pharmaceutical co-crystal formation represents a straightforward way to dramatically influence the solid-state properties of a drug substance, particularly its solubility and hence bioavailability. This short review summarises this highly topical field, covering why the topic is of interest in pharmaceutical formulation, the definitions and practical scope of co-crystals, co-crystal preparation and characterisation, and implications for regulatory control and intellectual property (IP) protection. Concepts are illustrated with highly selected examples of pharmaceutical co-crystal systems within the wider context of crystal engineering and research in molecular solids.


Steed, J. (2013). The role of co-crystals in pharmaceutical design. Trends in Pharmacological Sciences, 34(3), 185-193.

Journal Article Type Article
Publication Date Mar 1, 2013
Deposit Date Mar 26, 2013
Publicly Available Date Apr 24, 2013
Journal Trends in Pharmacological Sciences
Print ISSN 0165-6147
Publisher Cell Press
Peer Reviewed Peer Reviewed
Volume 34
Issue 3
Pages 185-193
Keywords Solid form, Polymorph, Solubility, Formulation, Solvate.


Accepted Journal Article (904 Kb)

Copyright Statement
NOTICE: this is the author’s version of a work that was accepted for publication in Trends in pharmacological sciences. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Trends in pharmacological sciences, 34 (3), March 2013, 10.1016/

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