Multidirectional Synthesis of Substituted Indazoles via Iridium-Catalyzed C-H Borylation

Sadler, S.A.; Hones, A.C.; Roberts, B.; Blakemore, D.C.; Marder, T.B.; Steel, P.G.

Abstract

In the absence of a steric directing group, iridium-catalyzed C–H borylation of N-protected indazoles occurs rapidly and selectively at C-3 and the resulting boronate esters can be utilized in a range of downstream conversions. The functional group tolerance of the iridium-catalyzed C–H borylation reaction enables simple and efficient multidirectional syntheses of substituted indazoles to be realized.

Citation

Sadler, S., Hones, A., Roberts, B., Blakemore, D., Marder, T., & Steel, P. (2015). Multidirectional Synthesis of Substituted Indazoles via Iridium-Catalyzed C-H Borylation. Journal of Organic Chemistry, 80(10), 5308-5314. https://doi.org/10.1021/acs.joc.5b00452

• Journal Article Type: Article
• Acceptance Date: May 12, 2015
• Publication Date: May 15, 2015
• Deposit Date: May 12, 2015
• Publicly Available Date: May 1, 2016
• Journal: Journal of Organic Chemistry
• Print ISSN: 0022-3263
• Electronic ISSN: 1520-6904
• Publisher: American Chemical Society
• Peer Reviewed: Peer Reviewed
• Volume: 80
• Issue: 10
• Pages: 5308-5314
• DOI: https://doi.org/10.1021/acs.joc.5b00452
• Public URL: https://durham-repository.worktribe.com/output/1438583