Fully biodegradable and biocompatible emulsion template polymer scaffolds by thiol-acrylate polymerisation of polycaprolactone macropolymers

Johnson, D.W.; Langford, C.R.; Didsbury, M.P.; Lipp, B.; Przyborski, S.A.; Cameron, N.R.

Abstract

The emulsion templating process offers a route to highly porous polymers with well-defined morphologies. This study describes the preparation of such porous polymers (polyHIPEs) via the photopolymerization of a multi-functional thiol and polycaprolactone macromonomer. The resulting materials have nominal porosities of 90% and 95%, and are seen to have an interconnected pore morphology, with an average pore diameter of approximately 60 μm. Initial biocompatibility assessments with fibroblast cells (L929) have shown that the polymers are capable of supporting cell growth over 7 days and degradation products are non-toxic to cells up to a concentration of 0.1 mg ml−1.

Citation

Johnson, D., Langford, C., Didsbury, M., Lipp, B., Przyborski, S., & Cameron, N. (2015). Fully biodegradable and biocompatible emulsion template polymer scaffolds by thiol-acrylate polymerisation of polycaprolactone macropolymers. Polymer Chemistry, 6(41), 7256-7263. https://doi.org/10.1039/c5py00721f

• Journal Article Type: Article
• Acceptance Date: Jun 8, 2015
• Online Publication Date: Jun 9, 2015
• Publication Date: Nov 7, 2015
• Deposit Date: Jan 4, 2016
• Publicly Available Date: Jun 8, 2016
• Journal: Polymer Chemistry
• Print ISSN: 1759-9954
• Electronic ISSN: 1759-9962
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 6
• Issue: 41
• Pages: 7256-7263
• DOI: https://doi.org/10.1039/c5py00721f
• Public URL: https://durham-repository.worktribe.com/output/1424171