Preparation of an antibacterial poly(ionic liquid) graft copolymer of hydroxyethyl cellulose

Joubert, Fanny; Yeo, R. Paul; Sharples, Gary J.; Musa, Osama M.; Hodgson, David R.W.; Cameron, Neil R.

Abstract

Poly(ionic liquid)s (P(IL)s) of different degrees of polymerisation (10, 50 and 100) were prepared via RAFT polymerisation using an alkyne-terminated xanthate as transfer agent, with a monomer conversion of up to ~80% and a ƉM of 1.5 for P(IL)100. Subsequently, P(IL) chains were coupled to 15N-labelled azido-functionalized HEC, forming graft copolymers of HEC with different chain length and graft densities which were characterised using (13C and 15N) CP-MAS NMR and FT-IR spectroscopies. The antibacterial activities of HEC-g-P(IL)s were tested against E. coli and S. aureus and were comparable to ampicillin, a well-known antibiotic, demonstrating efficient activity of the graft copolymers against bacteria. Moreover, HEC-g-P(IL)s were slightly more effective against E. coli than S. aureus. A decrease in graft density of P(IL)10 on the HEC backbone decreased the activity of the graft copolymers against both bacteria. These findings suggest that HEC-g-P(IL) could find applications as an antiseptic compound, for example in paint formulation.

Citation

Joubert, F., Yeo, R. P., Sharples, G. J., Musa, O. M., Hodgson, D. R., & Cameron, N. R. (2015). Preparation of an antibacterial poly(ionic liquid) graft copolymer of hydroxyethyl cellulose. Biomacromolecules, 16(12), 397-3979. https://doi.org/10.1021/acs.biomac.5b01300

• Journal Article Type: Article
• Acceptance Date: Nov 4, 2015
• Online Publication Date: Nov 6, 2015
• Publication Date: Dec 14, 2015
• Deposit Date: Nov 9, 2015
• Publicly Available Date: Nov 6, 2016
• Journal: Biomacromolecules
• Print ISSN: 1525-7797
• Electronic ISSN: 1526-4602
• Publisher: American Chemical Society
• Peer Reviewed: Peer Reviewed
• Volume: 16
• Issue: 12
• Pages: 397-3979
• DOI: https://doi.org/10.1021/acs.biomac.5b01300