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Preparation of an antibacterial poly(ionic liquid) graft copolymer of hydroxyethyl cellulose

Joubert, Fanny; Yeo, R. Paul; Sharples, Gary J.; Musa, Osama M.; Hodgson, David R.W.; Cameron, Neil R.

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Authors

Fanny Joubert

R. Paul Yeo

Osama M. Musa

Neil R. Cameron



Abstract

Poly(ionic liquid)s (P(IL)s) of different degrees of polymerisation (10, 50 and 100) were prepared via RAFT polymerisation using an alkyne-terminated xanthate as transfer agent, with a monomer conversion of up to ~80% and a ƉM of 1.5 for P(IL)100. Subsequently, P(IL) chains were coupled to 15N-labelled azido-functionalized HEC, forming graft copolymers of HEC with different chain length and graft densities which were characterised using (13C and 15N) CP-MAS NMR and FT-IR spectroscopies. The antibacterial activities of HEC-g-P(IL)s were tested against E. coli and S. aureus and were comparable to ampicillin, a well-known antibiotic, demonstrating efficient activity of the graft copolymers against bacteria. Moreover, HEC-g-P(IL)s were slightly more effective against E. coli than S. aureus. A decrease in graft density of P(IL)10 on the HEC backbone decreased the activity of the graft copolymers against both bacteria. These findings suggest that HEC-g-P(IL) could find applications as an antiseptic compound, for example in paint formulation.

Citation

Joubert, F., Yeo, R. P., Sharples, G. J., Musa, O. M., Hodgson, D. R., & Cameron, N. R. (2015). Preparation of an antibacterial poly(ionic liquid) graft copolymer of hydroxyethyl cellulose. Biomacromolecules, 16(12), 397-3979. https://doi.org/10.1021/acs.biomac.5b01300

Journal Article Type Article
Acceptance Date Nov 4, 2015
Online Publication Date Nov 6, 2015
Publication Date Dec 14, 2015
Deposit Date Nov 9, 2015
Publicly Available Date Nov 6, 2016
Journal Biomacromolecules
Print ISSN 1525-7797
Electronic ISSN 1526-4602
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 16
Issue 12
Pages 397-3979
DOI https://doi.org/10.1021/acs.biomac.5b01300

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Copyright Statement
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Biomacromolecules, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/acs.biomac.5b01300.






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